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Q46480

- PUR9_ALLVD

UniProt

Q46480 - PUR9_ALLVD

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Allochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / D) (Chromatium vinosum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciAVIN572477:GCJK-833-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:Alvin_0822
OrganismiAllochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / D) (Chromatium vinosum)
Taxonomic identifieri572477 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesChromatiaceaeAllochromatium
ProteomesiUP000001441: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 519519Bifunctional purine biosynthesis protein PurHPRO_0000192083Add
BLAST

Proteomic databases

PRIDEiQ46480.

Structurei

3D structure databases

ProteinModelPortaliQ46480.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.By similarity

Sequence similaritiesi

Belongs to the PurH family.Curated

Phylogenomic databases

HOGENOMiHOG000230372.
KOiK00602.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q46480-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQPIQRALIS VSDKTGLLDF ARVLAARGVE ILSTGGTARL LADNGLTVVE
60 70 80 90 100
VSDHTGFPEM MDGRVKTLHP RIHGGILGRR GLDDAVMTEH GIPPIDLVVV
110 120 130 140 150
NLYPFEQTVA NPDCDLETAI ENIDIGGPTL LRAAAKNHAS VTVVVDAADY
160 170 180 190 200
ERVAEEIQSS GGVSEATRFD LAAKVFEHTA RYDGAIANYL SARAESEAGA
210 220 230 240 250
SFPRTLTLQF KRRQSMRYGE NPHQNAAFYV EHQVAEAGIS TATQIQGKEL
260 270 280 290 300
SYNNIADTDA ALECVKQFDE APACVIVKHA NPCGVAFGAT LLEAYDRAYQ
310 320 330 340 350
TDPESAFGGI IAFNRELDAE TAHAIVERQF VEVIIAPRVS DAARAAVASK
360 370 380 390 400
PNVRLLECGD WSREPGDRLD FKRVNGGLLV QDADLRLTDQ IRTVTERTPT
410 420 430 440 450
EAELADLLFT WRVAKFVKSN AIVYGRERMT IGVGAGQMSR VNSARIAAIK
460 470 480 490 500
AEHAGLTVAG SVMASDAFFP FRDGIDQAAA AGIKAVIQPG GSMRDAEVIA
510
AANEHGMAMV FTGMRHFRH
Length:519
Mass (Da):55,955
Last modified:June 15, 2010 - v2
Checksum:iCB94BD901535C695
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001896 Genomic DNA. Translation: ADC61769.1.
L76417 Genomic DNA. Translation: AAB02978.1.
RefSeqiWP_012970045.1. NC_013851.1.
YP_003442801.1. NC_013851.1.

Genome annotation databases

EnsemblBacteriaiADC61769; ADC61769; Alvin_0822.
GeneIDi8786160.
KEGGialv:Alvin_0822.
PATRICi31921397. VBIAllVin64954_0821.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001896 Genomic DNA. Translation: ADC61769.1 .
L76417 Genomic DNA. Translation: AAB02978.1 .
RefSeqi WP_012970045.1. NC_013851.1.
YP_003442801.1. NC_013851.1.

3D structure databases

ProteinModelPortali Q46480.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q46480.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADC61769 ; ADC61769 ; Alvin_0822 .
GeneIDi 8786160.
KEGGi alv:Alvin_0822.
PATRICi 31921397. VBIAllVin64954_0821.

Phylogenomic databases

HOGENOMi HOG000230372.
KOi K00602.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci AVIN572477:GCJK-833-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequence of chromosome of Allochromatium vinosum DSM 180."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Munk A.C., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Zigann R., Dahl C., Woyke T.
    Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17899 / DSM 180 / NBRC 103801 / D.
  2. Chen Y.L., Knaff D.B.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 442-519.

Entry informationi

Entry nameiPUR9_ALLVD
AccessioniPrimary (citable) accession number: Q46480
Secondary accession number(s): D3RQG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 15, 2010
Last modified: October 29, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3