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Q46480 (PUR9_ALLVD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:Alvin_0822
OrganismAllochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / D) (Chromatium vinosum) [Complete proteome] [HAMAP]
Taxonomic identifier572477 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaChromatialesChromatiaceaeAllochromatium

Protein attributes

Sequence length519 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 519519Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_0000192083

Sequences

Sequence LengthMass (Da)Tools
Q46480 [UniParc].

Last modified June 15, 2010. Version 2.
Checksum: CB94BD901535C695

FASTA51955,955
        10         20         30         40         50         60 
MQPIQRALIS VSDKTGLLDF ARVLAARGVE ILSTGGTARL LADNGLTVVE VSDHTGFPEM 

        70         80         90        100        110        120 
MDGRVKTLHP RIHGGILGRR GLDDAVMTEH GIPPIDLVVV NLYPFEQTVA NPDCDLETAI 

       130        140        150        160        170        180 
ENIDIGGPTL LRAAAKNHAS VTVVVDAADY ERVAEEIQSS GGVSEATRFD LAAKVFEHTA 

       190        200        210        220        230        240 
RYDGAIANYL SARAESEAGA SFPRTLTLQF KRRQSMRYGE NPHQNAAFYV EHQVAEAGIS 

       250        260        270        280        290        300 
TATQIQGKEL SYNNIADTDA ALECVKQFDE APACVIVKHA NPCGVAFGAT LLEAYDRAYQ 

       310        320        330        340        350        360 
TDPESAFGGI IAFNRELDAE TAHAIVERQF VEVIIAPRVS DAARAAVASK PNVRLLECGD 

       370        380        390        400        410        420 
WSREPGDRLD FKRVNGGLLV QDADLRLTDQ IRTVTERTPT EAELADLLFT WRVAKFVKSN 

       430        440        450        460        470        480 
AIVYGRERMT IGVGAGQMSR VNSARIAAIK AEHAGLTVAG SVMASDAFFP FRDGIDQAAA 

       490        500        510 
AGIKAVIQPG GSMRDAEVIA AANEHGMAMV FTGMRHFRH 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequence of chromosome of Allochromatium vinosum DSM 180."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Munk A.C., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Zigann R., Dahl C., Woyke T.
Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17899 / DSM 180 / NBRC 103801 / D.
[2]Chen Y.L., Knaff D.B.
Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 442-519.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001896 Genomic DNA. Translation: ADC61769.1.
L76417 Genomic DNA. Translation: AAB02978.1.
RefSeqYP_003442801.1. NC_013851.1.

3D structure databases

ProteinModelPortalQ46480.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ46480.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADC61769; ADC61769; Alvin_0822.
GeneID8786160.
KEGGalv:Alvin_0822.
PATRIC31921397. VBIAllVin64954_0821.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000230372.
KOK00602.

Enzyme and pathway databases

BioCycAVIN572477:GCJK-833-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_ALLVD
AccessionPrimary (citable) accession number: Q46480
Secondary accession number(s): D3RQG4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 15, 2010
Last modified: February 19, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways