Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q46480

- PUR9_ALLVD

UniProt

Q46480 - PUR9_ALLVD

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Allochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / D) (Chromatium vinosum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 2 (15 Jun 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciAVIN572477:GCJK-833-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurH
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
    Alternative name(s):
    AICAR transformylase
    IMP cyclohydrolase (EC:3.5.4.10)
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
    Gene namesi
    Name:purH
    Ordered Locus Names:Alvin_0822
    OrganismiAllochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / D) (Chromatium vinosum)
    Taxonomic identifieri572477 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesChromatiaceaeAllochromatium
    ProteomesiUP000001441: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 519519Bifunctional purine biosynthesis protein PurHPRO_0000192083Add
    BLAST

    Proteomic databases

    PRIDEiQ46480.

    Structurei

    3D structure databases

    ProteinModelPortaliQ46480.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.By similarity

    Sequence similaritiesi

    Belongs to the PurH family.Curated

    Phylogenomic databases

    HOGENOMiHOG000230372.
    KOiK00602.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q46480-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQPIQRALIS VSDKTGLLDF ARVLAARGVE ILSTGGTARL LADNGLTVVE    50
    VSDHTGFPEM MDGRVKTLHP RIHGGILGRR GLDDAVMTEH GIPPIDLVVV 100
    NLYPFEQTVA NPDCDLETAI ENIDIGGPTL LRAAAKNHAS VTVVVDAADY 150
    ERVAEEIQSS GGVSEATRFD LAAKVFEHTA RYDGAIANYL SARAESEAGA 200
    SFPRTLTLQF KRRQSMRYGE NPHQNAAFYV EHQVAEAGIS TATQIQGKEL 250
    SYNNIADTDA ALECVKQFDE APACVIVKHA NPCGVAFGAT LLEAYDRAYQ 300
    TDPESAFGGI IAFNRELDAE TAHAIVERQF VEVIIAPRVS DAARAAVASK 350
    PNVRLLECGD WSREPGDRLD FKRVNGGLLV QDADLRLTDQ IRTVTERTPT 400
    EAELADLLFT WRVAKFVKSN AIVYGRERMT IGVGAGQMSR VNSARIAAIK 450
    AEHAGLTVAG SVMASDAFFP FRDGIDQAAA AGIKAVIQPG GSMRDAEVIA 500
    AANEHGMAMV FTGMRHFRH 519
    Length:519
    Mass (Da):55,955
    Last modified:June 15, 2010 - v2
    Checksum:iCB94BD901535C695
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001896 Genomic DNA. Translation: ADC61769.1.
    L76417 Genomic DNA. Translation: AAB02978.1.
    RefSeqiYP_003442801.1. NC_013851.1.

    Genome annotation databases

    EnsemblBacteriaiADC61769; ADC61769; Alvin_0822.
    GeneIDi8786160.
    KEGGialv:Alvin_0822.
    PATRICi31921397. VBIAllVin64954_0821.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001896 Genomic DNA. Translation: ADC61769.1 .
    L76417 Genomic DNA. Translation: AAB02978.1 .
    RefSeqi YP_003442801.1. NC_013851.1.

    3D structure databases

    ProteinModelPortali Q46480.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q46480.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADC61769 ; ADC61769 ; Alvin_0822 .
    GeneIDi 8786160.
    KEGGi alv:Alvin_0822.
    PATRICi 31921397. VBIAllVin64954_0821.

    Phylogenomic databases

    HOGENOMi HOG000230372.
    KOi K00602.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci AVIN572477:GCJK-833-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Allochromatium vinosum DSM 180."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Munk A.C., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Zigann R., Dahl C., Woyke T.
      Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17899 / DSM 180 / NBRC 103801 / D.
    2. Chen Y.L., Knaff D.B.
      Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 442-519.

    Entry informationi

    Entry nameiPUR9_ALLVD
    AccessioniPrimary (citable) accession number: Q46480
    Secondary accession number(s): D3RQG4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 75 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3