Q46337 (SOXA_CORS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sarcosine oxidase subunit alpha
Short name=Sarcosine oxidase subunit
EC=1.5.3.1

Gene names

Name:

soxA

Organism

Corynebacterium sp. (strain P-1)

Taxonomic identifier

69006 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	967 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the oxidative demethylation of sarcosine to yield glycine, hydrogen peroxide and 5,10-methylenetetrahydrofolate.
Catalytic activity	Sarcosine + H2O + O2 = glycine + formaldehyde + H2O2.
Cofactor	FAD.
Subunit structure	Heterotetramer (alpha 100 kDa, beta 42 kDa, gamma 20 kDa, and delta 6 kDa).
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro tetrahydrofolate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: InterPro sarcosine oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 967	967	Sarcosine oxidase subunit alpha		PRO_0000122627

Sequences

	Sequence		Length	Mass (Da)
	Q46337 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: C5F8A61F021134E9	FASTA	967	102,767
	10 20 30 40 50 60 MSQNTSYRLP AEQSPAARID RGEALVLTVD GKQLEAFRGD TVASAMLANG QRACGNSMYL 70 80 90 100 110 120 DRPRGIFSAG VEEPNALVTV EARHEQDINE SMLAATTVPV TANLSATLLR GLGVLDPSTD 130 140 150 160 170 180 PAYYDHVHVH TDVLVVGAGP AGLAAAREAS RSGARVLLLD ERAEAGGSLR DAAGEQIDGQ 190 200 210 220 230 240 DAAAWIDATV AELAAAEETT HLQRTTVLGS YDANYVVAVQ RRTVHLDGPS GAGVSRERIW 250 260 270 280 290 300 HIRANQVVLA TGAHERPIVF ENNDRPGIML AGAVRSYLNC YGVRAGSQIV VATTNDSAYP 310 320 330 340 350 360 LVADLAASGG VVAVIDARTT VSAAAAEAVG AGVRVITGSV VVDTEANESG ELSAVIVAEL 370 380 390 400 410 420 GEDRELGEPQ RFEADVLAVA GGFNPVVHLH SQRQGKLVWD TSIHAFVPDA AVANQHLAGA 430 440 450 460 470 480 LTGLFDTASA LSTGAAVGAA AATAAGFERI AQVPQALPVP AGETRPVWLV PSLNGDQATN 490 500 510 520 530 540 YTTHFVDLQR DQTVSDVLRA TGAGLESVEH IKRYTSISTA NDQGKTSGVA AIGVIAAVLG 550 560 570 580 590 600 IENPAEIGTT TFRAPYTPVA FAALAGRTRG ELLDPARITP MHSWHLAQGA KFEDVGQWKR 610 620 630 640 650 660 AWYFPQDGED MDAAVYRECA AVRESVGMLD ATTLGKIEIR GADAAEFLNR IYTNGYTKLK 670 680 690 700 710 720 VGMARYGVMC KADGMVFDDG VTLRLAEDRF LMHTTTGGAA GVLDWLEEWL QTEWPELDVT 730 740 750 760 770 780 CTSVTEQLAT VAVVGPRSRD VVAKLVTGLD VSNDAFKFMS FQDVTLDSGI EARISRISFS 790 800 810 820 830 840 GELAYEIAIP SWHGLRVWED VYAAGQEFNI TPYGTETMHV LRAEKGFIIV GQDTDGTVTP 850 860 870 880 890 900 QDAGMEWVVS KLKDFVGKRS FSREDNLRED RKHLVSVLPV DTALRLAEGA ALVADGAVET 910 920 930 940 950 960 EGCTPMEGWV TSSYNSPALG RTFGLALIKN GRSRIGEVLK TPVNGQLVDV LVSDLVLFDP EGSRRDG

References

[1]	"Sequence analysis of sarcosine oxidase and nearby genes reveals homologies with key enzymes of folate one-carbon metabolism." Chlumsky L.J., Zhang L., Jorns M.S. J. Biol. Chem. 270:18252-18259(1995) [PubMed: 7543100] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U23955 Genomic DNA. Translation: AAC43461.1.
3D structure databases
ProteinModelPortal	Q46337.
SMR	Q46337. Positions 8-966.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-8521.
Family and domain databases
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006277. SoxA. [Graphical view]
PANTHER	PTHR13847:SF82. PTHR13847:SF82. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF037980. SoxA. 1 hit.
PRINTS	PR00368. FADPNR.
TIGRFAMs	TIGR01372. SoxA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SOXA_CORS1

Accession

Primary (citable) accession number: Q46337

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	October 19, 2011
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program