Reviewed, UniProtKB/Swiss-Prot Q46225 (KDSA_CHLPS)

Names and origin

Protein names

Recommended name:
    2-dehydro-3-deoxyphosphooctonate aldolase
    EC=2.5.1.55
Alternative name(s):
    Phospho-2-dehydro-3-deoxyoctonate aldolase
    3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase
    KDO-8-phosphate synthetase
      Short name=KDO 8-P synthase
      Short name=KDOPS

Gene names

Name:

kdsA

Organism

Chlamydia psittaci (Chlamydophila psittaci)

Taxonomic identifier

83554 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydophila

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate. HAMAP MF_00056
Pathway	Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3. HAMAP MF_00056 Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP MF_00056
Subcellular location	Cytoplasm HAMAP MF_00056.
Sequence similarities	Belongs to the kdsA family.

Ontologies

Keywords
Biological process	Lipopolysaccharide biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Gene Ontology (GO)
Biological process	keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-deoxy-8-phosphooctulonate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	2-dehydro-3-deoxyphosphooctonate aldolase HAMAP MF_00056		PRO_0000187118

Sequences

	Sequence		Length	Mass (Da)
	Q46225-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 55A4F40ABFB7ADE4	FASTA	269	29,382
	10 20 30 40 50 60 MFSDKMILIA GPCVIEEEET TLEIASKIQE IVAPYTDHIH WIFKSSYDKA NRSSINSYRG 70 80 90 100 110 120 PGLQEGLRIL SKVKQTFGVE ILTDVHSPEE ARAAAEVCDI LQIPAFLCRQ TDLLVAAAET 130 140 150 160 170 180 HAVINIKKGQ FLSPWDMQGP VDKVLSTGNS KIILTERGCS FGYNNLVSDM RSIAVLSKMG 190 200 210 220 230 240 FPVVFDGTHS VQLPGGLKTH SGGQTEFIPT LTRAALAAGA HGLFIETHMN PAIAKSDAAS 250 260 MLSLKTFEAL LPIWNQLYQC VRSFEMAAV

References

[1]

"Molecular cloning, sequence analysis and functional characterization of the gene kdsA, encoding 3-deoxy-D-manno-2-octulosonate-8-phosphate synthase of Chlamydia psittaci 6BC." Brabetz W., Brade H. Eur. J. Biochem. 244:66-73(1997) [PubMed: 9063447] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 6BC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z50747 Genomic DNA. Translation: CAA90622.1.
3D structure databases
SMR	Q46225. Positions 4-265.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.5.1.55. 264833.
Family and domain databases
HAMAP	MF_00056. KDO8P_synth. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR006218. DAHP1/KDSA. IPR006269. KDO8P_synthase. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR21057:SF2. KDO8P_synthase. 1 hit.
Pfam	PF00793. DAHP_synth_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR01362. KDO8P_synth. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KDSA_CHLPS

Accession

Primary (citable) accession number: Q46225

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	February 9, 2010
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)