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Protein
Submitted name:

Iota toxin component Ia

Gene
N/A
Organism
Clostridium perfringens
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei393NADPCombined sources1
Binding sitei421NADPCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi336 – 342NADCombined sources7
Nucleotide bindingi336 – 341NADPCombined sources6
Nucleotide bindingi376 – 379NADCombined sources4
Nucleotide bindingi376 – 379NADPCombined sources4
Nucleotide bindingi390 – 393NADCombined sources4
Nucleotide bindingi419 – 421NADCombined sources3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

NADCombined sources, NADPCombined sources, Nucleotide-bindingCombined sources

Enzyme and pathway databases

BRENDAi2.4.2.B12. 1503.
2.4.2.B13. 1503.

Names & Taxonomyi

Protein namesi
Submitted name:
Iota toxin component IaImported
OrganismiClostridium perfringensImported
Taxonomic identifieri1502 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_500423235229 – 454Sequence analysisAdd BLAST426

Interactioni

Protein-protein interaction databases

DIPiDIP-46105N.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GIQX-ray1.80A/B42-454[»]
1GIRX-ray2.10A42-454[»]
3BUZX-ray2.81A42-454[»]
4GY2X-ray2.71A42-454[»]
4H03X-ray1.75A42-454[»]
4H0TX-ray2.20A42-454[»]
4H0VX-ray2.03A42-454[»]
4H0XX-ray2.33A42-454[»]
4H0YX-ray1.94A42-454[»]
ProteinModelPortaliQ46220.
SMRiQ46220.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ46220.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 247ADPrib_exo_ToxInterPro annotationAdd BLAST189
Domaini263 – 453ADPrib_exo_ToxInterPro annotationAdd BLAST191

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili51 – 85Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Family and domain databases

InterProiIPR003540. ADP-ribosyltransferase.
IPR016013. Binary_toxinA_clost-typ.
[Graphical view]
PfamiPF03496. ADPrib_exo_Tox. 2 hits.
[Graphical view]
PRINTSiPR01390. BINARYTOXINA.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q46220-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKVNKSISV FLILYLILTS SFPSYTYAQD LQIASNYITD RAFIERPEDF
60 70 80 90 100
LKDKENAIQW EKKEAERVEK NLDTLEKEAL ELYKKDSEQI SNYSQTRQYF
110 120 130 140 150
YDYQIESNPR EKEYKNLRNA ISKNKIDKPI NVYYFESPEK FAFNKEIRTE
160 170 180 190 200
NQNEISLEKF NELKETIQDK LFKQDGFKDV SLYEPGNGDE KPTPLLIHLK
210 220 230 240 250
LPKNTGMLPY INSNDVKTLI EQDYSIKIDK IVRIVIEGKQ YIKAEASIVN
260 270 280 290 300
SLDFKDDVSK GDLWGKENYS DWSNKLTPNE LADVNDYMRG GYTAINNYLI
310 320 330 340 350
SNGPLNNPNP ELDSKVNNIE NALKLTPIPS NLIVYRRSGP QEFGLTLTSP
360 370 380 390 400
EYDFNKIENI DAFKEKWEGK VITYPNFIST SIGSVNMSAF AKRKIILRIN
410 420 430 440 450
IPKDSPGAYL SAIPGYAGEY EVLLNHGSKF KINKVDSYKD GTVTKLILDA

TLIN
Length:454
Mass (Da):52,317
Last modified:November 1, 1996 - v1
Checksum:i5765009F6ADDEAD4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73562 Genomic DNA. Translation: CAA51959.1.
PIRiI40861.
S68632.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73562 Genomic DNA. Translation: CAA51959.1.
PIRiI40861.
S68632.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GIQX-ray1.80A/B42-454[»]
1GIRX-ray2.10A42-454[»]
3BUZX-ray2.81A42-454[»]
4GY2X-ray2.71A42-454[»]
4H03X-ray1.75A42-454[»]
4H0TX-ray2.20A42-454[»]
4H0VX-ray2.03A42-454[»]
4H0XX-ray2.33A42-454[»]
4H0YX-ray1.94A42-454[»]
ProteinModelPortaliQ46220.
SMRiQ46220.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46105N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi2.4.2.B12. 1503.
2.4.2.B13. 1503.

Miscellaneous databases

EvolutionaryTraceiQ46220.

Family and domain databases

InterProiIPR003540. ADP-ribosyltransferase.
IPR016013. Binary_toxinA_clost-typ.
[Graphical view]
PfamiPF03496. ADPrib_exo_Tox. 2 hits.
[Graphical view]
PRINTSiPR01390. BINARYTOXINA.
ProtoNetiSearch...

Entry informationi

Entry nameiQ46220_CLOPF
AccessioniPrimary (citable) accession number: Q46220
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.