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Protein

Anaerobic regulatory protein

Gene

fnr

Organism
Capnocytophaga ochracea (strain ATCC 27872 / DSM 7271 / JCM 12966 / NCTC 12371 / VPI 2845) (Bacteroides ochraceus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

It is involved in the activation of genes necessary for anaerobic respiration. It probably also activates genes involved in the production of virulence factors.

Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi1 – 11Iron-sulfur (4Fe-4S)Sequence Analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation, Virulence

Keywords - Ligandi

4Fe-4S, DNA-binding, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic regulatory protein
Gene namesi
Name:fnr
OrganismiCapnocytophaga ochracea (strain ATCC 27872 / DSM 7271 / JCM 12966 / NCTC 12371 / VPI 2845) (Bacteroides ochraceus)
Taxonomic identifieri521097 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeCapnocytophaga

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›92›92Anaerobic regulatory proteinPRO_0000100174Add
BLAST

Expressioni

Inductioni

By anaerobiosis.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ46158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – ›92›50HTH crp-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH crp-type DNA-binding domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00325. Crp. 1 hit.
[Graphical view]
PRINTSiPR00034. HTHCRP.
PROSITEiPS51063. HTH_CRP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q46158-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
CEIPFETLDD LSGKMPNLRQ QMMRLMSGEI KGDQDMILLL SKKNAEERLD
60 70 80 90
VFIYNLSRRF AQRGFSPREF RLTMTRGDIG NYLGLTVETI SR
Length:92
Mass (Da):10,704
Last modified:November 1, 1996 - v1
Checksum:iDB67C6DA55FFB748
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei92 – 921

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78252 Genomic DNA. Translation: BAA11316.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78252 Genomic DNA. Translation: BAA11316.1.

3D structure databases

ProteinModelPortaliQ46158.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00325. Crp. 1 hit.
[Graphical view]
PRINTSiPR00034. HTHCRP.
PROSITEiPS51063. HTH_CRP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Novel FNR homologues identified in four representative oral facultative anaerobes: Capnocytophaga ochracea, Capnocytophaga sputigena, Haemophilus aphrophilus, and Actinobacillus actinomycetemcomitans."
    Hattori T., Takahashi K., Nakanishi T., Ohta H., Fukui K., Taniguchi S., Takigawa M.
    FEMS Microbiol. Lett. 137:213-220(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiFNR_CAPOD
AccessioniPrimary (citable) accession number: Q46158
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: November 1, 1996
Last modified: May 27, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

The DNA coding for this protein is not found in the complete genome of strain ATCC 27872 / DSM 7271 / JCM 12966 / VPI 2845.Curated

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.