Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Alpha-toxin

Gene
N/A
Organism
Clostridium novyi
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BRENDAi2.4.1.B62. 1497.

Protein family/group databases

CAZyiGT44. Glycosyltransferase Family 44.
TCDBi1.C.57.1.4. the clostridial cytotoxin (cct) family.

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha-toxinImported
OrganismiClostridium novyiImported
Taxonomic identifieri1542 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VK9X-ray2.85A1-551[»]
ProteinModelPortaliQ46149.
SMRiQ46149. Positions 2-541.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ46149.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini574 – 787214Peptidase C80InterPro annotationAdd
BLAST

Family and domain databases

InterProiIPR018337. Cell_wall/Cho-bd_repeat.
IPR020974. CPD_dom.
IPR029044. Nucleotide-diphossugar_trans.
IPR024770. TcdA/TcdB_cat.
IPR024772. TcdA/TcdB_N.
IPR024769. TcdA/TcdB_pore_forming.
[Graphical view]
PfamiPF11713. Peptidase_C80. 1 hit.
PF12919. TcdA_TcdB. 1 hit.
PF12920. TcdA_TcdB_pore. 1 hit.
PF12918. TcdB_N. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS51771. CGT_MARTX_CPD. 1 hit.
PS51170. CW. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q46149-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLITREQLMK IASIPLKRKE PEYNLILDAL ENFNRDIEGT SVKEIYSKLS
60 70 80 90 100
KLNELVDNYQ TKYPSSGRNL ALENFRDSLY SELRELIKNS RTSTIASKNL
110 120 130 140 150
SFIWIGGPIS DQSLEYYNMW KMFNKDYNIR LFYDKNSLLV NTLKTAIIQE
160 170 180 190 200
SSKVIIEQNQ SNILDGTYGH NKFYSDRMKL IYRYKRELKM LYENMKQNNS
210 220 230 240 250
VDDIIINFLS NYFKYDIGKL NNQKENNNNK MIAIGATDIN TENILTNKLK
260 270 280 290 300
SYYYQELIQT NNLAAASDIL RIAILKKYGG VYCDLDFLPG VNLSLFNDIS
310 320 330 340 350
KPNGMDSNYW EAAIFEAIAN EKKLMNNYPY KYMEQVPSEI KERILSFVRN
360 370 380 390 400
HDINDLILPL GDIKISQLEI LLSRLKAATG KKTFSNAFII SNNDSLTLNN
410 420 430 440 450
LISQLENRYE ILNSIIQEKF KICETYDSYI NSVSELVLET TPKNLSMDGS
460 470 480 490 500
SFYQQIIGYL SSGFKPEVNS TVFFSGPNIY SSATCDTYHF IKNTFDMLSS
510 520 530 540 550
QNQEIFEASN NLYFSKTHDE FKSSWLLRSN IAEKEFQKLI KTYIGRTLNY
560 570 580 590 600
EDGLNFNKWK RVTTSELLKV IEEVNSTKIY ENYDLNMILQ IQGDDISYES
610 620 630 640 650
AVNVFGKNPN KSILIQGVDD FANVFYFENG IVQSDNINNI LSRFNDIKKI
660 670 680 690 700
KLTLIGHGEN VFNPKLFGGK TVNDLYTNII KPKLQHLLER EGVILKNKYL
710 720 730 740 750
KINILGCYMF TPKVDINSTF VGKLFNKISR DLQPKGFSKN QLEISANKYA
760 770 780 790 800
IRINREGKRE VLDYFGKWVS NTDLIAEQIS NKYVVYWNEV ENTLSARVEQ
810 820 830 840 850
LNKVAEFAKD INSIIQTTNN QELKQSLVNT YADLITTLYS ELLKEDIPFE
860 870 880 890 900
LDNIQIKERI ILNEISRLHD FSNIILDFYQ KNNISNNMII LFDSIIKEKD
910 920 930 940 950
YYNVKLANKI TGETSVIKTY SDSLWNFTNK YKKIVDDIKG IIVKDINGEF
960 970 980 990 1000
IKKADFEIEQ NPSLLNSAML MQLLIDYKPY TEILTNMNTS LKVQAYAQIF
1010 1020 1030 1040 1050
QLSIGAIQEA TEIVTIISDA LNANFNILSK LKVGSSVASV IIDGINLIAA
1060 1070 1080 1090 1100
LTELKNVKTN FERKLIEAKV GMYSIGFILE SSSLISGLLG ATAVSEILGV
1110 1120 1130 1140 1150
ISVPVAGILV GLPSLVNNIL VLGEKYNQIL DYFSKFYPIV GKNPFSIQDN
1160 1170 1180 1190 1200
IIIPYDDIAI TELNFKYNKF KYGYAKISGL KVGLVTHIGE NIDHYFSAPS
1210 1220 1230 1240 1250
LDHYIELSIY PALKLNDTNL PKGNVVLLPS GLNKVYKPEI SAIAGANSQE
1260 1270 1280 1290 1300
GNGVEVLNLI RNYYVDSNGN TKFPWKYEAP FEYSFSYMRV EYFDTKVNVI
1310 1320 1330 1340 1350
LDNENKTLII PVLTIDEMRN KISYEILGDG GQYNVILPVN QTNINIVSNK
1360 1370 1380 1390 1400
NDIWNFDVSY IVKESKIEDN KFVLDGFINN IFSTLKVSND GFKIGKQFIS
1410 1420 1430 1440 1450
IKNTPRAINL SFKINNNIVI VSIYLNHEKS NSITIISSDL NDIKNNFDNL
1460 1470 1480 1490 1500
LDNINYIGLG SISDNTINCI VRNDEVYMEG KIFLNEKKLV FIQNELELHL
1510 1520 1530 1540 1550
YDSVNKDSQY LINNPINNVV KYKDGYIVEG TFLINSTENK YSLYIENNKI
1560 1570 1580 1590 1600
MLKGLYLESS VFKTIQDKIY SKEKVNDYIL SLIKKFFTVN IQLCPFMIVS
1610 1620 1630 1640 1650
GVDENNRYLE YMLSTNNKWI INGGYWENDF NNYKIVDFEK CNVIVSGSNK
1660 1670 1680 1690 1700
LNSEGDLADT IDVLDKDLEN LYIDSVIIIP KVYTKKIIIH PIPNNPQINI
1710 1720 1730 1740 1750
INTQSIHDKC HLIIDSVLTN NYHWESDGDD LIITNGLDIN IRILQGLSFG
1760 1770 1780 1790 1800
FKYKNIYLKF SNYDELSLND FLLQNYNVKG LYYINGELHY KNIPGDTFEY
1810 1820 1830 1840 1850
GWINIDSRWY FFDSINLIAK KGYQEIEGER YYFNPNTGVQ ESGVFLTPNG
1860 1870 1880 1890 1900
LEYFTNKHAS SKRWGRAINY TGWLTLDGNK YYFQSNSKAV TGLQKISDKY
1910 1920 1930 1940 1950
YYFNDNGQMQ IKWQIINNNK YYFDGNTGEA IIGWFNNNKE RYYFDSEGRL
1960 1970 1980 1990 2000
LTGYQVIGDK SYYFSDNING NWEEGSGVLK SGIFKTPSGF KLFSSEGDKS
2010 2020 2030 2040 2050
AINYKGWLDL NGNKYYFNSD SIAVTGSYNI KGIQYYFNPK TAVLTNGWYT
2060 2070 2080 2090 2100
LDNNNYYVSN GHNVLGYQDI DGKGYYFDPS TGIQKAGVFP TPNGLRYFTM
2110 2120 2130 2140 2150
KPIDGQRWGQ CIDYTGWLHL NGNKYYFGYY NSAVTGWRVL GGKRYFFNIK
2160 2170
TGAATTGLLT LSGKRYYFNE KGEQLTLV
Length:2,178
Mass (Da):250,136
Last modified:November 1, 1996 - v1
Checksum:i9B0ADCE031C4A75A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48636 Genomic DNA. Translation: CAA88565.1.
PIRiS55805.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48636 Genomic DNA. Translation: CAA88565.1.
PIRiS55805.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VK9X-ray2.85A1-551[»]
ProteinModelPortaliQ46149.
SMRiQ46149. Positions 2-541.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGT44. Glycosyltransferase Family 44.
TCDBi1.C.57.1.4. the clostridial cytotoxin (cct) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi2.4.1.B62. 1497.

Miscellaneous databases

EvolutionaryTraceiQ46149.

Family and domain databases

InterProiIPR018337. Cell_wall/Cho-bd_repeat.
IPR020974. CPD_dom.
IPR029044. Nucleotide-diphossugar_trans.
IPR024770. TcdA/TcdB_cat.
IPR024772. TcdA/TcdB_N.
IPR024769. TcdA/TcdB_pore_forming.
[Graphical view]
PfamiPF11713. Peptidase_C80. 1 hit.
PF12919. TcdA_TcdB. 1 hit.
PF12920. TcdA_TcdB_pore. 1 hit.
PF12918. TcdB_N. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS51771. CGT_MARTX_CPD. 1 hit.
PS51170. CW. 14 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequencing and analysis of the gene encoding the alpha-toxin of Clostridium novyi proves its homology to toxins A and B of Clostridium difficile."
    Hofmann F., Herrmann A., Habermann E., von Eichel-Streiber C.
    Mol. Gen. Genet. 247:670-679(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC19402Imported.
  2. "Conformational changes and reaction of clostridial glycosylating toxins."
    Ziegler M.O., Jank T., Aktories K., Schulz G.E.
    J. Mol. Biol. 377:1346-1356(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 1-551.

Entry informationi

Entry nameiQ46149_CLONO
AccessioniPrimary (citable) accession number: Q46149
Secondary accession number(s): Q46147, Q46148
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: April 13, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.