Q46121 (DBH_CAMJE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA-binding protein HU

Alternative name(s):
HCj

Gene names

Name:	hup
Synonyms:	hupB
Ordered Locus Names:	Cj0913c

Organism

Campylobacter jejuni

Taxonomic identifier

197 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	98 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the bacterial histone-like protein family.

Ontologies

Keywords
Biological process	DNA condensation
Ligand	DNA-binding
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	chromosome condensation Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 98	98	DNA-binding protein HU		PRO_0000104928

Sequences

	Sequence		Length	Mass (Da)
	Q46121 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: E3CC1FE3BEA70333	FASTA	98	10,274
	10 20 30 40 50 60 MTKADFISLV AQTAGLTKKD ATTATDAVIS TITDVLAKGD SISFIGFGTF STQERAAREA 70 80 90 RVPSTGKTIK VPATRVAKFK VGKNLKEAVA KASGKKKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of the hup gene encoding a histone-like protein of Campylobacter jejuni." Konkel M.E., Marconi R.T., Mead D.J., Cieplak W. Jr. Gene 146:83-86(1994) [PubMed: 8063109] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-13. Strain: F38011.
[2]	"Genomic and proteomic identification of a DNA-binding protein biomarker used in the discrimination of Campylobacter species and strains by MALDI-TOF-MS." Fagerquist C.K., Miller W.G., Harden L.A., Bates A.H., Vensel W.H., Wang G., Mandrell R.E. Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: RM1046, RM1049, RM1052, RM1167, RM1170, RM1849, RM1852, RM1860, RM1861, RM2227, RM2229, RM2232, RM2239, RM3193, RM3197, RM3198, RM3200, RM3201, RM3203, RM3204, RM3205, RM3206, RM3207, RM3208, RM3209, RM3210 and RM3782.
[3]	"The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences." Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M. , van Vliet A.H.M., Whitehead S., Barrell B.G. Nature 403:665-668(2000) [PubMed: 10688204] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 11168 / Serotype O:2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L25627 Genomic DNA. Translation: AAA60954.1. AY751940 Genomic DNA. Translation: AAW83330.1. AY751941 Genomic DNA. Translation: AAW83331.1. AY751943 Genomic DNA. Translation: AAW83333.1. AY751945 Genomic DNA. Translation: AAW83335.1. AY751946 Genomic DNA. Translation: AAW83336.1. AY751954 Genomic DNA. Translation: AAW83344.1. AY751955 Genomic DNA. Translation: AAW83345.1. AY751959 Genomic DNA. Translation: AAW83349.1. AY751960 Genomic DNA. Translation: AAW83350.1. AY751980 Genomic DNA. Translation: AAW83370.1. AY751982 Genomic DNA. Translation: AAW83372.1. AY751983 Genomic DNA. Translation: AAW83373.1. AY751984 Genomic DNA. Translation: AAW83374.1. AY751992 Genomic DNA. Translation: AAW83382.1. AY751994 Genomic DNA. Translation: AAW83384.1. AY751995 Genomic DNA. Translation: AAW83385.1. AY751996 Genomic DNA. Translation: AAW83386.1. AY751997 Genomic DNA. Translation: AAW83387.1. AY751998 Genomic DNA. Translation: AAW83388.1. AY751999 Genomic DNA. Translation: AAW83389.1. AY752000 Genomic DNA. Translation: AAW83390.1. AY752001 Genomic DNA. Translation: AAW83391.1. AY752002 Genomic DNA. Translation: AAW83392.1. AY752003 Genomic DNA. Translation: AAW83393.1. AY752004 Genomic DNA. Translation: AAW83394.1. AY752005 Genomic DNA. Translation: AAW83395.1. AY752017 Genomic DNA. Translation: AAW83407.1. AL111168 Genomic DNA. Translation: CAL35033.1.
PIR	I40616.
RefSeq	YP_002344311.1. NC_002163.1.
3D structure databases
ProteinModelPortal	Q46121.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q46121. 66 interactions.
MINT	MINT-6484961.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	905212.
GenomeReviews	Gene locus Cj0913c in contig AL111168_GR.
KEGG	cje:Cj0913c.
PATRIC	20058770. VBICamJej33762_0897.
Phylogenomic databases
HOGENOM	HBG705085.
OMA	DHIAGSA.
ProtClustDB	CLSK878989.
Enzyme and pathway databases
BioCyc	CJEJ192222:CJ0913C-MONOMER.
Family and domain databases
InterPro	IPR023630. DNA-bd_HU/IHF. IPR000119. Hist_DNA-bd_bac. IPR010992. IHF-like_DNA-bd. [Graphical view]
Gene3D	G3DSA:4.10.520.10. Hist_DNA_bd_bac. 1 hit.
KO	K03530.
Pfam	PF00216. Bac_DNA_binding. 1 hit. [Graphical view]
PRINTS	PR01727. DNABINDINGHU.
SMART	SM00411. BHL. 1 hit. [Graphical view]
SUPFAM	SSF47729. IHF_like_DNA_bnd. 1 hit.
PROSITE	PS00045. HISTONE_LIKE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DBH_CAMJE

Accession

Primary (citable) accession number: Q46121
Secondary accession number(s): Q3MLK5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program