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Q46121 (DBH_CAMJE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA-binding protein HU
Alternative name(s):
HCj
Gene names
Name:hup
Synonyms:hupB
Ordered Locus Names:Cj0913c
OrganismCampylobacter jejuni
Taxonomic identifier197 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter

Protein attributes

Sequence length98 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the bacterial histone-like protein family.

Ontologies

Keywords
   Biological processDNA condensation
   LigandDNA-binding
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological processchromosome condensation

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9898DNA-binding protein HU
PRO_0000104928

Sequences

Sequence LengthMass (Da)Tools
Q46121 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: E3CC1FE3BEA70333

FASTA9810,274
        10         20         30         40         50         60 
MTKADFISLV AQTAGLTKKD ATTATDAVIS TITDVLAKGD SISFIGFGTF STQERAAREA 

        70         80         90 
RVPSTGKTIK VPATRVAKFK VGKNLKEAVA KASGKKKK 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and expression of the hup gene encoding a histone-like protein of Campylobacter jejuni."
Konkel M.E., Marconi R.T., Mead D.J., Cieplak W. Jr.
Gene 146:83-86(1994) [PubMed: 8063109] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-13.
Strain: F38011.
[2]"Genomic and proteomic identification of a DNA-binding protein biomarker used in the discrimination of Campylobacter species and strains by MALDI-TOF-MS."
Fagerquist C.K., Miller W.G., Harden L.A., Bates A.H., Vensel W.H., Wang G., Mandrell R.E.
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: RM1046, RM1049, RM1052, RM1167, RM1170, RM1849, RM1852, RM1860, RM1861, RM2227, RM2229, RM2232, RM2239, RM3193, RM3197, RM3198, RM3200, RM3201, RM3203, RM3204, RM3205, RM3206, RM3207, RM3208, RM3209, RM3210 and RM3782.
[3]"The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences."
Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M. expand/collapse author list , van Vliet A.H.M., Whitehead S., Barrell B.G.
Nature 403:665-668(2000) [PubMed: 10688204] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCTC 11168 / Serotype O:2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L25627 Genomic DNA. Translation: AAA60954.1.
AY751940 Genomic DNA. Translation: AAW83330.1.
AY751941 Genomic DNA. Translation: AAW83331.1.
AY751943 Genomic DNA. Translation: AAW83333.1.
AY751945 Genomic DNA. Translation: AAW83335.1.
AY751946 Genomic DNA. Translation: AAW83336.1.
AY751954 Genomic DNA. Translation: AAW83344.1.
AY751955 Genomic DNA. Translation: AAW83345.1.
AY751959 Genomic DNA. Translation: AAW83349.1.
AY751960 Genomic DNA. Translation: AAW83350.1.
AY751980 Genomic DNA. Translation: AAW83370.1.
AY751982 Genomic DNA. Translation: AAW83372.1.
AY751983 Genomic DNA. Translation: AAW83373.1.
AY751984 Genomic DNA. Translation: AAW83374.1.
AY751992 Genomic DNA. Translation: AAW83382.1.
AY751994 Genomic DNA. Translation: AAW83384.1.
AY751995 Genomic DNA. Translation: AAW83385.1.
AY751996 Genomic DNA. Translation: AAW83386.1.
AY751997 Genomic DNA. Translation: AAW83387.1.
AY751998 Genomic DNA. Translation: AAW83388.1.
AY751999 Genomic DNA. Translation: AAW83389.1.
AY752000 Genomic DNA. Translation: AAW83390.1.
AY752001 Genomic DNA. Translation: AAW83391.1.
AY752002 Genomic DNA. Translation: AAW83392.1.
AY752003 Genomic DNA. Translation: AAW83393.1.
AY752004 Genomic DNA. Translation: AAW83394.1.
AY752005 Genomic DNA. Translation: AAW83395.1.
AY752017 Genomic DNA. Translation: AAW83407.1.
AL111168 Genomic DNA. Translation: CAL35033.1.
PIRI40616.
RefSeqYP_002344311.1. NC_002163.1.

3D structure databases

ProteinModelPortalQ46121.
ModBaseSearch...

Protein-protein interaction databases

IntActQ46121. 66 interactions.
MINTMINT-6484961.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID905212.
GenomeReviewsGene locus Cj0913c in contig AL111168_GR.
KEGGcje:Cj0913c.
PATRIC20058770. VBICamJej33762_0897.

Phylogenomic databases

HOGENOMHBG705085.
OMADHIAGSA.
ProtClustDBCLSK878989.

Enzyme and pathway databases

BioCycCJEJ192222:CJ0913C-MONOMER.

Family and domain databases

InterProIPR023630. DNA-bd_HU/IHF.
IPR000119. Hist_DNA-bd_bac.
IPR010992. IHF-like_DNA-bd.
[Graphical view]
Gene3DG3DSA:4.10.520.10. Hist_DNA_bd_bac. 1 hit.
KOK03530.
PfamPF00216. Bac_DNA_binding. 1 hit.
[Graphical view]
PRINTSPR01727. DNABINDINGHU.
SMARTSM00411. BHL. 1 hit.
[Graphical view]
SUPFAMSSF47729. IHF_like_DNA_bnd. 1 hit.
PROSITEPS00045. HISTONE_LIKE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDBH_CAMJE
AccessionPrimary (citable) accession number: Q46121
Secondary accession number(s): Q3MLK5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families