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Reviewed, UniProtKB/Swiss-Prot Q46121 (DBH_CAMJE)

Last modified June 16, 2009. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    DNA-binding protein HU
Alternative name(s):
    HCj
Gene names
Name: hup
Synonyms: hupB
Ordered Locus Names: Cj0913c
OrganismCampylobacter jejuni [Complete proteome] [HAMAP]
Taxonomic identifier197 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

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Protein attributes

Sequence length98 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the bacterial histone-like protein family.

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Ontologies

Keywords
   Biological processDNA condensation
   LigandDNA-binding
   Technical termComplete proteome
Direct protein sequencing
Gene Ontology (GO)
   Biological processmitotic chromosome condensation

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9898DNA-binding protein HU
PRO_0000104928

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Sequences

Sequence LengthMass (Da)Tools
Q46121-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: E3CC1FE3BEA70333

FASTA9810,274
        10         20         30         40         50         60 
MTKADFISLV AQTAGLTKKD ATTATDAVIS TITDVLAKGD SISFIGFGTF STQERAAREA 

        70         80         90 
RVPSTGKTIK VPATRVAKFK VGKNLKEAVA KASGKKKK

« Hide

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References

« Hide 'large scale' references
[1]"Cloning and expression of the hup gene encoding a histone-like protein of Campylobacter jejuni."
Konkel M.E., Marconi R.T., Mead D.J., Cieplak W. Jr.
Gene 146:83-86(1994) [PubMed: 8063109] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-13.
Strain: F38011.
[2]"Genomic and proteomic identification of a DNA-binding protein biomarker used in the discrimination of Campylobacter species and strains by MALDI-TOF-MS."
Fagerquist C.K., Miller W.G., Harden L.A., Bates A.H., Vensel W.H., Wang G., Mandrell R.E.
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: RM1046, RM1049, RM1052, RM1167, RM1170, RM1849, RM1852, RM1860, RM1861, RM2227, RM2229, RM2232, RM2239, RM3193, RM3197, RM3198, RM3200, RM3201, RM3203, RM3204, RM3205, RM3206, RM3207, RM3208, RM3209, RM3210 and RM3782.
[3]"The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences."
Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M. expand/collapse author list , van Vliet A.H.M., Whitehead S., Barrell B.G.
Nature 403:665-668(2000) [PubMed: 10688204] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCTC 11168 / Serotype O:2.

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Cross-references

Sequence databases

L25627 Genomic DNA. Translation: AAA60954.1.
AY751940 Genomic DNA. Translation: AAW83330.1.
AY751941 Genomic DNA. Translation: AAW83331.1.
AY751943 Genomic DNA. Translation: AAW83333.1.
AY751945 Genomic DNA. Translation: AAW83335.1.
AY751946 Genomic DNA. Translation: AAW83336.1.
AY751954 Genomic DNA. Translation: AAW83344.1.
AY751955 Genomic DNA. Translation: AAW83345.1.
AY751959 Genomic DNA. Translation: AAW83349.1.
AY751960 Genomic DNA. Translation: AAW83350.1.
AY751980 Genomic DNA. Translation: AAW83370.1.
AY751982 Genomic DNA. Translation: AAW83372.1.
AY751983 Genomic DNA. Translation: AAW83373.1.
AY751984 Genomic DNA. Translation: AAW83374.1.
AY751992 Genomic DNA. Translation: AAW83382.1.
AY751994 Genomic DNA. Translation: AAW83384.1.
AY751995 Genomic DNA. Translation: AAW83385.1.
AY751996 Genomic DNA. Translation: AAW83386.1.
AY751997 Genomic DNA. Translation: AAW83387.1.
AY751998 Genomic DNA. Translation: AAW83388.1.
AY751999 Genomic DNA. Translation: AAW83389.1.
AY752000 Genomic DNA. Translation: AAW83390.1.
AY752001 Genomic DNA. Translation: AAW83391.1.
AY752002 Genomic DNA. Translation: AAW83392.1.
AY752003 Genomic DNA. Translation: AAW83393.1.
AY752004 Genomic DNA. Translation: AAW83394.1.
AY752005 Genomic DNA. Translation: AAW83395.1.
AY752017 Genomic DNA. Translation: AAW83407.1.
AL111168 Genomic DNA. Translation: CAL35033.1.
PIRI40616.
RefSeqYP_002344311.1.

3D structure databases

HSSPHSSP built from PDB template 1B8Z based on UniProtKB P36206.
ModBaseSearch...

Protein-protein interaction databases

IntActQ46121. 66 interactions.

Genome annotation databases

GeneID905212.
GenomeReviewsGene locus Cj0913c in contig AL111168_GR.
KEGGcje:Cj0913c.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAQ46121. KASTGRN.

Enzyme and pathway databases

BioCycCJEJ192222:CJ0913C-MON.

Family and domain databases

InterProIPR000119. Hist_DNA_bd_bac.
[Graphical view]
Gene3DG3DSA:4.10.520.10. Hist_DNA_bd_bac. 1 hit.
PfamPF00216. Bac_DNA_binding. 1 hit.
[Graphical view]
PRINTSPR01727. DNABINDINGHU.
ProDomPD000945. Bac_DNAbind. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00411. BHL. 1 hit.
[Graphical view]
PROSITEPS00045. HISTONE_LIKE. False negative.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameDBH_CAMJE
AccessionPrimary (citable) accession number: Q46121
Secondary accession number(s): Q3MLK5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: June 16, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents