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Q46106

- FTN_CAMJE

UniProt

Q46106 - FTN_CAMJE

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Protein
Ferritin
Gene
ftn, cft, Cj0612c
Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Iron-storage protein.

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi17 – 171Iron 1 By similarity
Metal bindingi50 – 501Iron 1 By similarity
Metal bindingi50 – 501Iron 2 By similarity
Metal bindingi53 – 531Iron 1 By similarity
Metal bindingi94 – 941Iron 2 By similarity
Metal bindingi127 – 1271Iron 2 By similarity

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. iron ion transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-599-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin (EC:1.16.3.1)
Gene namesi
Name:ftn
Synonyms:cft
Ordered Locus Names:Cj0612c
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000000799: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 167167Ferritin
PRO_0000201095Add
BLAST

PTM databases

PhosSiteiP0804292.

Interactioni

Subunit structurei

Homooligomer of 24 subunits that assemble into a spherical protein shell (12 +/- 1 nM diameter) that can sequester at least 2000 iron atoms By similarity.

Protein-protein interaction databases

STRINGi192222.Cj0612c.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 3330
Helixi37 – 6226
Turni63 – 653
Helixi83 – 11028
Helixi114 – 1196
Helixi121 – 14424
Turni147 – 1493
Helixi150 – 16314

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KRQX-ray2.70A1-167[»]
ProteinModelPortaliQ46106.
SMRiQ46106. Positions 1-164.

Miscellaneous databases

EvolutionaryTraceiQ46106.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 145145Ferritin-like diiron
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1528.
HOGENOMiHOG000223382.
KOiK02217.
OMAiCEDKGFE.
OrthoDBiEOG6G4W12.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q46106-1 [UniParc]FASTAAdd to Basket

« Hide

MLSKEVVKLL NEQINKEMYA ANLYLSMSSW CYENSLDGAG AFLFAHASEE    50
SDHAKKLITY LNETDSHVEL QEVKQPEQNF KSLLDVFEKT YEHEQFITKS 100
INTLVEHMLT HKDYSTFNFL QWYVSEQHEE EALFRGIVDK IKLIGEHGNG 150
LYLADQYIKN IALSRKK 167
Length:167
Mass (Da):19,486
Last modified:November 1, 1996 - v1
Checksum:iB2CFB612DAD0D9DA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D64082 Genomic DNA. Translation: BAA10964.1.
AL111168 Genomic DNA. Translation: CAL34758.1.
PIRiS77578.
RefSeqiWP_002852256.1. NC_002163.1.
YP_002344042.1. NC_002163.1.

Genome annotation databases

EnsemblBacteriaiCAL34758; CAL34758; Cj0612c.
GeneIDi904939.
KEGGicje:Cj0612c.
PATRICi20058168. VBICamJej33762_0604.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D64082 Genomic DNA. Translation: BAA10964.1 .
AL111168 Genomic DNA. Translation: CAL34758.1 .
PIRi S77578.
RefSeqi WP_002852256.1. NC_002163.1.
YP_002344042.1. NC_002163.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1KRQ X-ray 2.70 A 1-167 [» ]
ProteinModelPortali Q46106.
SMRi Q46106. Positions 1-164.
ModBasei Search...

Protein-protein interaction databases

STRINGi 192222.Cj0612c.

PTM databases

PhosSitei P0804292.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL34758 ; CAL34758 ; Cj0612c .
GeneIDi 904939.
KEGGi cje:Cj0612c.
PATRICi 20058168. VBICamJej33762_0604.

Phylogenomic databases

eggNOGi COG1528.
HOGENOMi HOG000223382.
KOi K02217.
OMAi CEDKGFE.
OrthoDBi EOG6G4W12.

Enzyme and pathway databases

BioCyci CJEJ192222:GJTS-599-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q46106.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
PANTHERi PTHR11431. PTHR11431. 1 hit.
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Construction of a ferritin-deficient mutant of Campylobacter jejuni: contribution of ferritin to iron storage and protection against oxidative stress."
    Wai S., Nakayama K., Umene K., Moriya T., Amako K.
    Mol. Microbiol. 20:1127-1134(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 11168.

Entry informationi

Entry nameiFTN_CAMJE
AccessioniPrimary (citable) accession number: Q46106
Secondary accession number(s): Q0PAQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi