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Q46106

- FTN_CAMJE

UniProt

Q46106 - FTN_CAMJE

Protein

Bacterial non-heme ferritin

Gene

ftn

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Iron-storage protein.

    Catalytic activityi

    4 Fe2+ + O2 + 6 H2O = 4 (FeO(OH)) + 8 H+.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi17 – 171Iron 1PROSITE-ProRule annotation
    Metal bindingi50 – 501Iron 1PROSITE-ProRule annotation
    Metal bindingi50 – 501Iron 2PROSITE-ProRule annotation
    Metal bindingi53 – 531Iron 1PROSITE-ProRule annotation
    Metal bindingi94 – 941Iron 2PROSITE-ProRule annotation
    Metal bindingi127 – 1271Iron 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ferric iron binding Source: InterPro
    2. ferroxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular iron ion homeostasis Source: UniProtKB-KW
    2. iron ion transport Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Iron storage

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciCJEJ192222:GJTS-599-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bacterial non-heme ferritin (EC:1.16.3.2)
    Gene namesi
    Name:ftn
    Synonyms:cft
    Ordered Locus Names:Cj0612c
    OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
    Taxonomic identifieri192222 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
    ProteomesiUP000000799: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 167167Bacterial non-heme ferritinPRO_0000201095Add
    BLAST

    PTM databases

    PhosSiteiP0804292.

    Interactioni

    Subunit structurei

    Homooligomer of 24 subunits that assemble into a spherical protein shell (12 +/- 1 nM diameter) that can sequester at least 2000 iron atoms.By similarity

    Protein-protein interaction databases

    STRINGi192222.Cj0612c.

    Structurei

    Secondary structure

    1
    167
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi4 – 3330
    Helixi37 – 6226
    Turni63 – 653
    Helixi83 – 11028
    Helixi114 – 1196
    Helixi121 – 14424
    Turni147 – 1493
    Helixi150 – 16314

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1KRQX-ray2.70A1-167[»]
    ProteinModelPortaliQ46106.
    SMRiQ46106. Positions 1-164.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ46106.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 145145Ferritin-like diironPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ferritin family. Prokaryotic subfamily.Curated
    Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1528.
    HOGENOMiHOG000223382.
    KOiK02217.
    OMAiCEDKGFE.
    OrthoDBiEOG6G4W12.

    Family and domain databases

    Gene3Di1.20.1260.10. 1 hit.
    InterProiIPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view]
    PANTHERiPTHR11431. PTHR11431. 1 hit.
    PfamiPF00210. Ferritin. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q46106-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSKEVVKLL NEQINKEMYA ANLYLSMSSW CYENSLDGAG AFLFAHASEE    50
    SDHAKKLITY LNETDSHVEL QEVKQPEQNF KSLLDVFEKT YEHEQFITKS 100
    INTLVEHMLT HKDYSTFNFL QWYVSEQHEE EALFRGIVDK IKLIGEHGNG 150
    LYLADQYIKN IALSRKK 167
    Length:167
    Mass (Da):19,486
    Last modified:November 1, 1996 - v1
    Checksum:iB2CFB612DAD0D9DA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D64082 Genomic DNA. Translation: BAA10964.1.
    AL111168 Genomic DNA. Translation: CAL34758.1.
    PIRiS77578.
    RefSeqiWP_002852256.1. NC_002163.1.
    YP_002344042.1. NC_002163.1.

    Genome annotation databases

    EnsemblBacteriaiCAL34758; CAL34758; Cj0612c.
    GeneIDi904939.
    KEGGicje:Cj0612c.
    PATRICi20058168. VBICamJej33762_0604.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D64082 Genomic DNA. Translation: BAA10964.1 .
    AL111168 Genomic DNA. Translation: CAL34758.1 .
    PIRi S77578.
    RefSeqi WP_002852256.1. NC_002163.1.
    YP_002344042.1. NC_002163.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1KRQ X-ray 2.70 A 1-167 [» ]
    ProteinModelPortali Q46106.
    SMRi Q46106. Positions 1-164.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 192222.Cj0612c.

    PTM databases

    PhosSitei P0804292.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAL34758 ; CAL34758 ; Cj0612c .
    GeneIDi 904939.
    KEGGi cje:Cj0612c.
    PATRICi 20058168. VBICamJej33762_0604.

    Phylogenomic databases

    eggNOGi COG1528.
    HOGENOMi HOG000223382.
    KOi K02217.
    OMAi CEDKGFE.
    OrthoDBi EOG6G4W12.

    Enzyme and pathway databases

    BioCyci CJEJ192222:GJTS-599-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q46106.

    Family and domain databases

    Gene3Di 1.20.1260.10. 1 hit.
    InterProi IPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view ]
    PANTHERi PTHR11431. PTHR11431. 1 hit.
    Pfami PF00210. Ferritin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Construction of a ferritin-deficient mutant of Campylobacter jejuni: contribution of ferritin to iron storage and protection against oxidative stress."
      Wai S., Nakayama K., Umene K., Moriya T., Amako K.
      Mol. Microbiol. 20:1127-1134(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCTC 11168.

    Entry informationi

    Entry nameiFTN_CAMJE
    AccessioniPrimary (citable) accession number: Q46106
    Secondary accession number(s): Q0PAQ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3