ID   ARLY_CAMJE              Reviewed;         460 AA.
AC   Q46104; Q0P9W8; Q9PP02;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   16-JUN-2009, entry version 69.
DE   RecName: Full=Argininosuccinate lyase;
DE            Short=ASAL;
DE            EC=4.3.2.1;
DE   AltName: Full=Arginosuccinase;
GN   Name=argH; OrderedLocusNames=Cj0931c;
OS   Campylobacter jejuni.
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=197;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 43431 / TGH 9011 / Serotype O:3;
RX   MEDLINE=94193530; PubMed=8144452;
RA   Hani E.K., Chan V.L.;
RT   "Cloning, characterization, and nucleotide sequence analysis of the
RT   argH gene from Campylobacter jejuni TGH9011 encoding argininosuccinate
RT   lyase.";
RL   J. Bacteriol. 176:1865-1871(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 11168 / Serotype O:2;
RX   MEDLINE=20150912; PubMed=10688204; DOI=10.1038/35001088;
RA   Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M.,
RA   Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S.,
RA   Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W.,
RA   Quail M.A., Rajandream M.A., Rutherford K.M., van Vliet A.H.M.,
RA   Whitehead S., Barrell B.G.;
RT   "The genome sequence of the food-borne pathogen Campylobacter jejuni
RT   reveals hypervariable sequences.";
RL   Nature 403:665-668(2000).
CC   -!- CATALYTIC ACTIVITY: 2-(N(omega)-L-arginino)succinate = fumarate +
CC       L-arginine.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-
CC       arginine from L-ornithine and carbamoyl phosphate: step 3/3.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC   -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC       subfamily.
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DR   EMBL; M77188; AAA93048.1; -; Genomic_DNA.
DR   EMBL; AL111168; CAL35051.1; -; Genomic_DNA.
DR   PIR; B81367; B81367.
DR   RefSeq; YP_002344329.1; -.
DR   HSSP; P24058; 1K7W.
DR   IntAct; Q46104; 25.
DR   GeneID; 905111; -.
DR   GenomeReviews; AL111168_GR; Cj0931c.
DR   KEGG; cje:Cj0931c; -.
DR   OMA; Q46104; ATDTRLY.
DR   BioCyc; CJEJ192222:CJ0931C-MON; -.
DR   BRENDA; 4.3.2.1; 255835.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004056; F:argininosuccinate lyase activity; IEA:HAMAP.
DR   GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR   HAMAP; MF_00006; -; 1.
DR   InterPro; IPR009049; Argininosuccinate_lyase.
DR   InterPro; IPR003031; D_crystallin.
DR   InterPro; IPR000362; Fumarate_lyase.
DR   PANTHER; PTHR11444:SF3; argH; 1.
DR   Pfam; PF00206; Lyase_1; 1.
DR   PRINTS; PR00145; DCRYSTALLIN.
DR   PRINTS; PR00149; FUMRATELYASE.
DR   TIGRFAMs; TIGR00838; argH; 1.
DR   PROSITE; PS00163; FUMARATE_LYASES; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Arginine biosynthesis; Complete proteome;
KW   Cytoplasm; Lyase.
FT   CHAIN         1    460       Argininosuccinate lyase.
FT                                /FTId=PRO_0000137753.
FT   CONFLICT     12     12       G -> D (in Ref. 1; AAA93048).
FT   CONFLICT     56     56       E -> Q (in Ref. 1; AAA93048).
FT   CONFLICT    134    134       L -> F (in Ref. 1; AAA93048).
FT   CONFLICT    208    209       AI -> RT (in Ref. 1; AAA93048).
FT   CONFLICT    216    216       K -> E (in Ref. 1; AAA93048).
FT   CONFLICT    225    225       P -> L (in Ref. 1; AAA93048).
FT   CONFLICT    383    383       P -> F (in Ref. 1; AAA93048).
FT   CONFLICT    387    391       AHFIV -> HIYS (in Ref. 1; AAA93048).
SQ   SEQUENCE   460 AA;  51660 MW;  66DA10A252B54249 CRC64;
     MKNEMWSGRF SGASDELLKE FNASLNVDKT LFNEDIQGSI AHATMLESCG ILKKEELDAI
     IKGLEQVRSE IEQGKFIFDI KDEDIHMAVE KRLSEIIGSE IGGRLHTARS RNDQVATDFK
     LFVKKSHIEL IKLLKELIQT MLEHAKVHKK TIMPSFTHLQ HAQPVSFSFY ILAYAFMLMR
     DIKRLQNSLE LADFSPLGSC ACAGTSYAIN RELSAKILGF KDIMPNAMDG VSDRDFALDL
     LYDIAVIFTH TSRLCEEMIL FSSSEFSFIT ISDSFSTGSS IMPQKKNPDV CELIRGKTGR
     VYGNLISLLT IMKALPLAYN KDMQEDKEGI FDSVKTAKDS LIILNAMLKE IQINKENMLN
     ACKKGHLLAT DLADYLVREK NIPFRKAHFI VGNVVAQAEA QGIDISEIKD LSKIDPVFDE
     KAMELLNFEF SLNSKQSEGS SSIASVEKQI QILEGFIQNL
//