Reviewed, UniProtKB/Swiss-Prot Q46104 (ARLY_CAMJE)

Names and origin

Protein names

Recommended name:
    Argininosuccinate lyase
      Short name=ASAL
    EC=4.3.2.1
Alternative name(s):
    Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	Cj0931c

Organism

Campylobacter jejuni [Complete proteome] [HAMAP]

Taxonomic identifier

197 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	460 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 460	460	Argininosuccinate lyase HAMAP MF_00006		PRO_0000137753
Experimental info
	Sequence conflict	12	1	G → D in AAA93048. Ref.1
	Sequence conflict	56	1	E → Q in AAA93048. Ref.1
	Sequence conflict	134	1	L → F in AAA93048. Ref.1
	Sequence conflict	208 – 209	2	AI → RT in AAA93048. Ref.1
	Sequence conflict	216	1	K → E in AAA93048. Ref.1
	Sequence conflict	225	1	P → L in AAA93048. Ref.1
	Sequence conflict	383	1	P → F in AAA93048. Ref.1
	Sequence conflict	387 – 391	5	AHFIV → HIYS in AAA93048. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q46104-1 [UniParc]. Last modified December 1, 2000. Version 2. Checksum: 66DA10A252B54249	FASTA	460	51,660
	10 20 30 40 50 60 MKNEMWSGRF SGASDELLKE FNASLNVDKT LFNEDIQGSI AHATMLESCG ILKKEELDAI 70 80 90 100 110 120 IKGLEQVRSE IEQGKFIFDI KDEDIHMAVE KRLSEIIGSE IGGRLHTARS RNDQVATDFK 130 140 150 160 170 180 LFVKKSHIEL IKLLKELIQT MLEHAKVHKK TIMPSFTHLQ HAQPVSFSFY ILAYAFMLMR 190 200 210 220 230 240 DIKRLQNSLE LADFSPLGSC ACAGTSYAIN RELSAKILGF KDIMPNAMDG VSDRDFALDL 250 260 270 280 290 300 LYDIAVIFTH TSRLCEEMIL FSSSEFSFIT ISDSFSTGSS IMPQKKNPDV CELIRGKTGR 310 320 330 340 350 360 VYGNLISLLT IMKALPLAYN KDMQEDKEGI FDSVKTAKDS LIILNAMLKE IQINKENMLN 370 380 390 400 410 420 ACKKGHLLAT DLADYLVREK NIPFRKAHFI VGNVVAQAEA QGIDISEIKD LSKIDPVFDE 430 440 450 460 KAMELLNFEF SLNSKQSEGS SSIASVEKQI QILEGFIQNL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, characterization, and nucleotide sequence analysis of the argH gene from Campylobacter jejuni TGH9011 encoding argininosuccinate lyase." Hani E.K., Chan V.L. J. Bacteriol. 176:1865-1871(1994) [PubMed: 8144452] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 43431 / TGH 9011 / Serotype O:3.
[2]	"The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences." Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M. , van Vliet A.H.M., Whitehead S., Barrell B.G. Nature 403:665-668(2000) [PubMed: 10688204] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 11168 / Serotype O:2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M77188 Genomic DNA. Translation: AAA93048.1. AL111168 Genomic DNA. Translation: CAL35051.1.
PIR	B81367.
RefSeq	YP_002344329.1.
3D structure databases
HSSP	HSSP built from PDB template 1K7W based on UniProtKB P24058.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q46104. 25 interactions.
Genome annotation databases
GeneID	905111.
GenomeReviews	Gene locus Cj0931c in contig AL111168_GR.
KEGG	cje:Cj0931c.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	Q46104. ATDTRLY.
Enzyme and pathway databases
BioCyc	CJEJ192222:CJ0931C-MON.
BRENDA	4.3.2.1. 255835.
Family and domain databases
HAMAP	MF_00006. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. [Graphical view]
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. DCRYSTALLIN. PR00149. FUMRATELYASE.
TIGRFAMs	TIGR00838. argH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_CAMJE

Accession

Primary (citable) accession number: Q46104
Secondary accession number(s): Q0P9W8, Q9PP02

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	December 1, 2000
Last modified:	June 16, 2009
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)