Q460N5 (PAR14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Poly [ADP-ribose] polymerase 14
Short name=PARP-14
EC=2.4.2.30

Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 8
Short name=ARTD8
B aggressive lymphoma protein 2

Gene names

Name:	PARP14
Synonyms:	BAL2, KIAA1268

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1801 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Enhances STAT6-dependent transcription By similarity. Has ADP-ribosyltransferase activity. Ref.5
Catalytic activity	NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
Subunit structure	Interacts with STAT6 By similarity.
Subcellular location	Nucleus. Cytoplasm. Note: In steady state cells the protein is mostly nuclear. A minor proportion is detected in the cytoplasm By similarity.
Sequence similarities	Contains 3 Macro domains. Contains 1 PARP catalytic domain. Contains 1 WWE domain.
Sequence caution	The sequence AAY64449.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAY64450.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB14089.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence DB237115 differs from that shown. Reason: Frameshift at position 48.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat
Ligand	NAD
Molecular function	Glycosyltransferase Transferase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from direct assay. Source: HPA
Molecular_function	NAD+ ADP-ribosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 6 (identifier: Q460N5-6)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: Q460N5-1)

Also known as: BAL2B;

The sequence of this isoform differs from the canonical sequence as follows:
     119-199: Missing.

Isoform 3 (identifier: Q460N5-3)

Also known as: BAL2A;

The sequence of this isoform differs from the canonical sequence as follows:
     1-283: Missing.

Isoform 4 (identifier: Q460N5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1648-1680: IERIQNPDLWNSYQAKKKTMDAKNGQTMNEKQL → VSLLLECSFWMVEISSVMVLYKIHFHSLPITFF
     1681-1801: Missing.

Isoform 5 (identifier: Q460N5-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1004: Missing.
     1005-1013: KGSLVSPGG → MYLRRLLRP

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1801

1801

Poly [ADP-ribose] polymerase 14

PRO_0000247589

Regions

Domain

791 – 978

188

Macro 1

Domain

1003 – 1190

188

Macro 2

Domain

1216 – 1387

172

Macro 3

Domain

1523 – 1601

79

WWE

Domain

1605 – 1801

197

PARP catalytic

Natural variations

Alternative sequence

1 – 1004

1004

Missing in isoform 5.

VSP_020013

Alternative sequence

1 – 283

283

Missing in isoform 3.

VSP_020014

Alternative sequence

119 – 199

81

Missing in isoform 1.

VSP_040876

Alternative sequence

1005 – 1013

9

KGSLVSPGG → MYLRRLLRP in isoform 5.

VSP_020017

Alternative sequence

1648 – 1680

33

IERIQ…NEKQL → VSLLLECSFWMVEISSVMVL YKIHFHSLPITFF in isoform 4.

VSP_020018

Alternative sequence

1681 – 1801

121

Missing in isoform 4.

VSP_020019

Experimental info

Sequence conflict

59

1

Y → C in DB237115. Ref.4

Sequence conflict

597

1

N → D in BAG65132. Ref.3

Sequence conflict

1239

1

E → G in BAA91897. Ref.3

Sequence conflict

1499

1

G → A in AAN08627. Ref.1

Sequence conflict

1521

1

A → G in AAN08627. Ref.1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1801

Helix Strand Turn

Details...

Beta strand

792 – 799

8

Beta strand

802 – 808

7

Beta strand

815 – 823

9

Helix

832 – 841

10

Helix

844 – 856

13

Beta strand

861 – 868

8

Beta strand

872 – 881

10

Helix

887 – 889

3

Helix

890 – 910

21

Beta strand

914 – 918

5

Turn

921 – 926

6

Helix

930 – 947

18

Beta strand

956 – 963

8

Helix

964 – 977

14

Beta strand

1007 – 1009

3

Beta strand

1015 – 1019

5

Helix

1023 – 1025

3

Beta strand

1028 – 1034

7

Beta strand

1041 – 1044

4

Helix

1045 – 1054

10

Helix

1057 – 1066

10

Beta strand

1076 – 1080

5

Beta strand

1084 – 1092

9

Helix

1098 – 1100

3

Helix

1102 – 1121

20

Beta strand

1126 – 1130

5

Helix

1141 – 1158

18

Beta strand

1166 – 1170

5

Helix

1176 – 1189

14

Beta strand

1213 – 1216

4

Beta strand

1220 – 1224

5

Beta strand

1227 – 1234

8

Helix

1236 – 1238

3

Beta strand

1242 – 1248

7

Helix

1258 – 1266

9

Helix

1268 – 1280

13

Beta strand

1284 – 1289

6

Beta strand

1293 – 1302

10

Helix

1307 – 1320

14

Beta strand

1325 – 1328

4

Helix

1340 – 1356

17

Beta strand

1365 – 1371

7

Helix

1373 – 1386

14

Beta strand

1617 – 1621

5

Helix

1629 – 1640

12

Beta strand

1643 – 1652

10

Helix

1654 – 1670

17

Turn

1671 – 1673

3

Beta strand

1677 – 1684

8

Helix

1686 – 1688

3

Helix

1689 – 1695

7

Turn

1699 – 1701

3

Helix

1704 – 1706

3

Beta strand

1707 – 1709

3

Beta strand

1713 – 1718

6

Helix

1719 – 1722

4

Turn

1725 – 1727

3

Beta strand

1736 – 1744

9

Beta strand

1747 – 1750

4

Beta strand

1763 – 1765

3

Beta strand

1771 – 1775

5

Beta strand

1777 – 1779

3

Beta strand

1781 – 1785

5

Beta strand

1791 – 1800

10

Sequences

	Sequence		Length	Mass (Da)
	Isoform 6 [UniParc]. Last modified April 5, 2011. Version 3. Checksum: 27B027DFC7E773BD	FASTA	1,801	202,800
	10 20 30 40 50 60 MAVPGSFPLL VEGSWGPDPP KNLNTKLQMY FQSPKRSGGG ECEVRQDPRS PSRFLVFFYP 70 80 90 100 110 120 EDVRQKVLER KNHELVWQGK GTFKLTVQLP ATPDEIDHVF EEELLTKESK TKEDVKEPDV 130 140 150 160 170 180 SEELDTKLPL DGGLDKMEDI PEECENISSL VAFENLKANV TDIMLILLVE NISGLSNDDF 190 200 210 220 230 240 QVEIIRDFDV AVVTFQKHID TIRFVDDCTK HHSIKQLQLS PRLLEVTNTI RVENLPPGAD 250 260 270 280 290 300 DYSLKLFFEN PYNGGGRVAN VEYFPEESSA LIEFFDRKVL DTIMATKLDF NKMPLSVFPY 310 320 330 340 350 360 YASLGTALYG KEKPLIKLPA PFEESLDLPL WKFLQKKNHL IEEINDEMRR CHCELTWSQL 370 380 390 400 410 420 SGKVTIRPAA TLVNEGRPRI KTWQADTSTT LSSIRSKYKV NPIKVDPTMW DTIKNDVKDD 430 440 450 460 470 480 RILIEFDTLK EMVILAGKSE DVQSIEVQVR ELIESTTQKI KREEQSLKEK MIISPGRYFL 490 500 510 520 530 540 LCHSSLLDHL LTECPEIEIC YDRVTQHLCL KGPSADVYKA KCEIQEKVYT MAQKNIQVSP 550 560 570 580 590 600 EIFQFLQQVN WKEFSKCLFI AQKILALYEL EGTTVLLTSC SSEALLEAEK QMLSALNYKR 610 620 630 640 650 660 IEVENKEVLH GKKWKGLTHN LLKKQNSSPN TVIINELTSE TTAEVIITGC VKEVNETYKL 670 680 690 700 710 720 LFNFVEQNMK IERLVEVKPS LVIDYLKTEK KLFWPKIKKV NVQVSFNPEN KQKGILLTGS 730 740 750 760 770 780 KTEVLKAVDI VKQVWDSVCV KSVHTDKPGA KQFFQDKARF YQSEIKRLFG CYIELQENEV 790 800 810 820 830 840 MKEGGSPAGQ KCFSRTVLAP GVVLIVQQGD LARLPVDVVV NASNEDLKHY GGLAAALSKA 850 860 870 880 890 900 AGPELQADCD QIVKREGRLL PGNATISKAG KLPYHHVIHA VGPRWSGYEA PRCVYLLRRA 910 920 930 940 950 960 VQLSLCLAEK YKYRSIAIPA ISSGVFGFPL GRCVETIVSA IKENFQFKKD GHCLKEIYLV 970 980 990 1000 1010 1020 DVSEKTVEAF AEAVKTVFKA TLPDTAAPPG LPPAAAGPGK TSWEKGSLVS PGGLQMLLVK 1030 1040 1050 1060 1070 1080 EGVQNAKTDV VVNSVPLDLV LSRGPLSKSL LEKAGPELQE ELDTVGQGVA VSMGTVLKTS 1090 1100 1110 1120 1130 1140 SWNLDCRYVL HVVAPEWRNG STSSLKIMED IIRECMEITE SLSLKSIAFP AIGTGNLGFP 1150 1160 1170 1180 1190 1200 KNIFAELIIS EVFKFSSKNQ LKTLQEVHFL LHPSDHENIQ AFSDEFARRA NGNLVSDKIP 1210 1220 1230 1240 1250 1260 KAKDTQGFYG TVSSPDSGVY EMKIGSIIFQ VASGDITKEE ADVIVNSTSN SFNLKAGVSK 1270 1280 1290 1300 1310 1320 AILECAGQNV ERECSQQAQQ RKNDYIITGG GFLRCKNIIH VIGGNDVKSS VSSVLQECEK 1330 1340 1350 1360 1370 1380 KNYSSICLPA IGTGNAKQHP DKVAEAIIDA IEDFVQKGSA QSVKKVKVVI FLPQVLDVFY 1390 1400 1410 1420 1430 1440 ANMKKREGTQ LSSQQSVMSK LASFLGFSKQ SPQKKNHLVL EKKTESATFR VCGENVTCVE 1450 1460 1470 1480 1490 1500 YAISWLQDLI EKEQCPYTSE DECIKDFDEK EYQELNELQK KLNINISLDH KRPLIKVLGI 1510 1520 1530 1540 1550 1560 SRDVMQARDE IEAMIKRVRL AKEQESRADC ISEFIEWQYN DNNTSHCFNK MTNLKLEDAR 1570 1580 1590 1600 1610 1620 REKKKTVDVK INHRHYTVNL NTYTATDTKG HSLSVQRLTK SKVDIPAHWS DMKQQNFCVV 1630 1640 1650 1660 1670 1680 ELLPSDPEYN TVASKFNQTC SHFRIEKIER IQNPDLWNSY QAKKKTMDAK NGQTMNEKQL 1690 1700 1710 1720 1730 1740 FHGTDAGSVP HVNRNGFNRS YAGKNAVAYG KGTYFAVNAN YSANDTYSRP DANGRKHVYY 1750 1760 1770 1780 1790 1800 VRVLTGIYTH GNHSLIVPPS KNPQNPTDLY DTVTDNVHHP SLFVAFYDYQ AYPEYLITFR K
	Isoform 1 (BAL2B) [UniParc]. Checksum: F7EAD232767F2867	FASTA	1,720	193,753
	10 20 30 40 50 60 MAVPGSFPLL VEGSWGPDPP KNLNTKLQMY FQSPKRSGGG ECEVRQDPRS PSRFLVFFYP 70 80 90 100 110 120 EDVRQKVLER KNHELVWQGK GTFKLTVQLP ATPDEIDHVF EEELLTKESK TKEDVKEPDT 130 140 150 160 170 180 IRFVDDCTKH HSIKQLQLSP RLLEVTNTIR VENLPPGADD YSLKLFFENP YNGGGRVANV 190 200 210 220 230 240 EYFPEESSAL IEFFDRKVLD TIMATKLDFN KMPLSVFPYY ASLGTALYGK EKPLIKLPAP 250 260 270 280 290 300 FEESLDLPLW KFLQKKNHLI EEINDEMRRC HCELTWSQLS GKVTIRPAAT LVNEGRPRIK 310 320 330 340 350 360 TWQADTSTTL SSIRSKYKVN PIKVDPTMWD TIKNDVKDDR ILIEFDTLKE MVILAGKSED 370 380 390 400 410 420 VQSIEVQVRE LIESTTQKIK REEQSLKEKM IISPGRYFLL CHSSLLDHLL TECPEIEICY 430 440 450 460 470 480 DRVTQHLCLK GPSADVYKAK CEIQEKVYTM AQKNIQVSPE IFQFLQQVNW KEFSKCLFIA 490 500 510 520 530 540 QKILALYELE GTTVLLTSCS SEALLEAEKQ MLSALNYKRI EVENKEVLHG KKWKGLTHNL 550 560 570 580 590 600 LKKQNSSPNT VIINELTSET TAEVIITGCV KEVNETYKLL FNFVEQNMKI ERLVEVKPSL 610 620 630 640 650 660 VIDYLKTEKK LFWPKIKKVN VQVSFNPENK QKGILLTGSK TEVLKAVDIV KQVWDSVCVK 670 680 690 700 710 720 SVHTDKPGAK QFFQDKARFY QSEIKRLFGC YIELQENEVM KEGGSPAGQK CFSRTVLAPG 730 740 750 760 770 780 VVLIVQQGDL ARLPVDVVVN ASNEDLKHYG GLAAALSKAA GPELQADCDQ IVKREGRLLP 790 800 810 820 830 840 GNATISKAGK LPYHHVIHAV GPRWSGYEAP RCVYLLRRAV QLSLCLAEKY KYRSIAIPAI 850 860 870 880 890 900 SSGVFGFPLG RCVETIVSAI KENFQFKKDG HCLKEIYLVD VSEKTVEAFA EAVKTVFKAT 910 920 930 940 950 960 LPDTAAPPGL PPAAAGPGKT SWEKGSLVSP GGLQMLLVKE GVQNAKTDVV VNSVPLDLVL 970 980 990 1000 1010 1020 SRGPLSKSLL EKAGPELQEE LDTVGQGVAV SMGTVLKTSS WNLDCRYVLH VVAPEWRNGS 1030 1040 1050 1060 1070 1080 TSSLKIMEDI IRECMEITES LSLKSIAFPA IGTGNLGFPK NIFAELIISE VFKFSSKNQL 1090 1100 1110 1120 1130 1140 KTLQEVHFLL HPSDHENIQA FSDEFARRAN GNLVSDKIPK AKDTQGFYGT VSSPDSGVYE 1150 1160 1170 1180 1190 1200 MKIGSIIFQV ASGDITKEEA DVIVNSTSNS FNLKAGVSKA ILECAGQNVE RECSQQAQQR 1210 1220 1230 1240 1250 1260 KNDYIITGGG FLRCKNIIHV IGGNDVKSSV SSVLQECEKK NYSSICLPAI GTGNAKQHPD 1270 1280 1290 1300 1310 1320 KVAEAIIDAI EDFVQKGSAQ SVKKVKVVIF LPQVLDVFYA NMKKREGTQL SSQQSVMSKL 1330 1340 1350 1360 1370 1380 ASFLGFSKQS PQKKNHLVLE KKTESATFRV CGENVTCVEY AISWLQDLIE KEQCPYTSED 1390 1400 1410 1420 1430 1440 ECIKDFDEKE YQELNELQKK LNINISLDHK RPLIKVLGIS RDVMQARDEI EAMIKRVRLA 1450 1460 1470 1480 1490 1500 KEQESRADCI SEFIEWQYND NNTSHCFNKM TNLKLEDARR EKKKTVDVKI NHRHYTVNLN 1510 1520 1530 1540 1550 1560 TYTATDTKGH SLSVQRLTKS KVDIPAHWSD MKQQNFCVVE LLPSDPEYNT VASKFNQTCS 1570 1580 1590 1600 1610 1620 HFRIEKIERI QNPDLWNSYQ AKKKTMDAKN GQTMNEKQLF HGTDAGSVPH VNRNGFNRSY 1630 1640 1650 1660 1670 1680 AGKNAVAYGK GTYFAVNANY SANDTYSRPD ANGRKHVYYV RVLTGIYTHG NHSLIVPPSK 1690 1700 1710 1720 NPQNPTDLYD TVTDNVHHPS LFVAFYDYQA YPEYLITFRK
	Isoform 3 (BAL2A) [UniParc]. Checksum: 8B8D7BFCB9682902	FASTA	1,518	170,601
	10 20 30 40 50 60 MATKLDFNKM PLSVFPYYAS LGTALYGKEK PLIKLPAPFE ESLDLPLWKF LQKKNHLIEE 70 80 90 100 110 120 INDEMRRCHC ELTWSQLSGK VTIRPAATLV NEGRPRIKTW QADTSTTLSS IRSKYKVNPI 130 140 150 160 170 180 KVDPTMWDTI KNDVKDDRIL IEFDTLKEMV ILAGKSEDVQ SIEVQVRELI ESTTQKIKRE 190 200 210 220 230 240 EQSLKEKMII SPGRYFLLCH SSLLDHLLTE CPEIEICYDR VTQHLCLKGP SADVYKAKCE 250 260 270 280 290 300 IQEKVYTMAQ KNIQVSPEIF QFLQQVNWKE FSKCLFIAQK ILALYELEGT TVLLTSCSSE 310 320 330 340 350 360 ALLEAEKQML SALNYKRIEV ENKEVLHGKK WKGLTHNLLK KQNSSPNTVI INELTSETTA 370 380 390 400 410 420 EVIITGCVKE VNETYKLLFN FVEQNMKIER LVEVKPSLVI DYLKTEKKLF WPKIKKVNVQ 430 440 450 460 470 480 VSFNPENKQK GILLTGSKTE VLKAVDIVKQ VWDSVCVKSV HTDKPGAKQF FQDKARFYQS 490 500 510 520 530 540 EIKRLFGCYI ELQENEVMKE GGSPAGQKCF SRTVLAPGVV LIVQQGDLAR LPVDVVVNAS 550 560 570 580 590 600 NEDLKHYGGL AAALSKAAGP ELQADCDQIV KREGRLLPGN ATISKAGKLP YHHVIHAVGP 610 620 630 640 650 660 RWSGYEAPRC VYLLRRAVQL SLCLAEKYKY RSIAIPAISS GVFGFPLGRC VETIVSAIKE 670 680 690 700 710 720 NFQFKKDGHC LKEIYLVDVS EKTVEAFAEA VKTVFKATLP DTAAPPGLPP AAAGPGKTSW 730 740 750 760 770 780 EKGSLVSPGG LQMLLVKEGV QNAKTDVVVN SVPLDLVLSR GPLSKSLLEK AGPELQEELD 790 800 810 820 830 840 TVGQGVAVSM GTVLKTSSWN LDCRYVLHVV APEWRNGSTS SLKIMEDIIR ECMEITESLS 850 860 870 880 890 900 LKSIAFPAIG TGNLGFPKNI FAELIISEVF KFSSKNQLKT LQEVHFLLHP SDHENIQAFS 910 920 930 940 950 960 DEFARRANGN LVSDKIPKAK DTQGFYGTVS SPDSGVYEMK IGSIIFQVAS GDITKEEADV 970 980 990 1000 1010 1020 IVNSTSNSFN LKAGVSKAIL ECAGQNVERE CSQQAQQRKN DYIITGGGFL RCKNIIHVIG 1030 1040 1050 1060 1070 1080 GNDVKSSVSS VLQECEKKNY SSICLPAIGT GNAKQHPDKV AEAIIDAIED FVQKGSAQSV 1090 1100 1110 1120 1130 1140 KKVKVVIFLP QVLDVFYANM KKREGTQLSS QQSVMSKLAS FLGFSKQSPQ KKNHLVLEKK 1150 1160 1170 1180 1190 1200 TESATFRVCG ENVTCVEYAI SWLQDLIEKE QCPYTSEDEC IKDFDEKEYQ ELNELQKKLN 1210 1220 1230 1240 1250 1260 INISLDHKRP LIKVLGISRD VMQARDEIEA MIKRVRLAKE QESRADCISE FIEWQYNDNN 1270 1280 1290 1300 1310 1320 TSHCFNKMTN LKLEDARREK KKTVDVKINH RHYTVNLNTY TATDTKGHSL SVQRLTKSKV 1330 1340 1350 1360 1370 1380 DIPAHWSDMK QQNFCVVELL PSDPEYNTVA SKFNQTCSHF RIEKIERIQN PDLWNSYQAK 1390 1400 1410 1420 1430 1440 KKTMDAKNGQ TMNEKQLFHG TDAGSVPHVN RNGFNRSYAG KNAVAYGKGT YFAVNANYSA 1450 1460 1470 1480 1490 1500 NDTYSRPDAN GRKHVYYVRV LTGIYTHGNH SLIVPPSKNP QNPTDLYDTV TDNVHHPSLF 1510 VAFYDYQAYP EYLITFRK
	Isoform 4 [UniParc]. Checksum: BCDDC89D51466E28	FASTA	1,680	189,177
	10 20 30 40 50 60 MAVPGSFPLL VEGSWGPDPP KNLNTKLQMY FQSPKRSGGG ECEVRQDPRS PSRFLVFFYP 70 80 90 100 110 120 EDVRQKVLER KNHELVWQGK GTFKLTVQLP ATPDEIDHVF EEELLTKESK TKEDVKEPDV 130 140 150 160 170 180 SEELDTKLPL DGGLDKMEDI PEECENISSL VAFENLKANV TDIMLILLVE NISGLSNDDF 190 200 210 220 230 240 QVEIIRDFDV AVVTFQKHID TIRFVDDCTK HHSIKQLQLS PRLLEVTNTI RVENLPPGAD 250 260 270 280 290 300 DYSLKLFFEN PYNGGGRVAN VEYFPEESSA LIEFFDRKVL DTIMATKLDF NKMPLSVFPY 310 320 330 340 350 360 YASLGTALYG KEKPLIKLPA PFEESLDLPL WKFLQKKNHL IEEINDEMRR CHCELTWSQL 370 380 390 400 410 420 SGKVTIRPAA TLVNEGRPRI KTWQADTSTT LSSIRSKYKV NPIKVDPTMW DTIKNDVKDD 430 440 450 460 470 480 RILIEFDTLK EMVILAGKSE DVQSIEVQVR ELIESTTQKI KREEQSLKEK MIISPGRYFL 490 500 510 520 530 540 LCHSSLLDHL LTECPEIEIC YDRVTQHLCL KGPSADVYKA KCEIQEKVYT MAQKNIQVSP 550 560 570 580 590 600 EIFQFLQQVN WKEFSKCLFI AQKILALYEL EGTTVLLTSC SSEALLEAEK QMLSALNYKR 610 620 630 640 650 660 IEVENKEVLH GKKWKGLTHN LLKKQNSSPN TVIINELTSE TTAEVIITGC VKEVNETYKL 670 680 690 700 710 720 LFNFVEQNMK IERLVEVKPS LVIDYLKTEK KLFWPKIKKV NVQVSFNPEN KQKGILLTGS 730 740 750 760 770 780 KTEVLKAVDI VKQVWDSVCV KSVHTDKPGA KQFFQDKARF YQSEIKRLFG CYIELQENEV 790 800 810 820 830 840 MKEGGSPAGQ KCFSRTVLAP GVVLIVQQGD LARLPVDVVV NASNEDLKHY GGLAAALSKA 850 860 870 880 890 900 AGPELQADCD QIVKREGRLL PGNATISKAG KLPYHHVIHA VGPRWSGYEA PRCVYLLRRA 910 920 930 940 950 960 VQLSLCLAEK YKYRSIAIPA ISSGVFGFPL GRCVETIVSA IKENFQFKKD GHCLKEIYLV 970 980 990 1000 1010 1020 DVSEKTVEAF AEAVKTVFKA TLPDTAAPPG LPPAAAGPGK TSWEKGSLVS PGGLQMLLVK 1030 1040 1050 1060 1070 1080 EGVQNAKTDV VVNSVPLDLV LSRGPLSKSL LEKAGPELQE ELDTVGQGVA VSMGTVLKTS 1090 1100 1110 1120 1130 1140 SWNLDCRYVL HVVAPEWRNG STSSLKIMED IIRECMEITE SLSLKSIAFP AIGTGNLGFP 1150 1160 1170 1180 1190 1200 KNIFAELIIS EVFKFSSKNQ LKTLQEVHFL LHPSDHENIQ AFSDEFARRA NGNLVSDKIP 1210 1220 1230 1240 1250 1260 KAKDTQGFYG TVSSPDSGVY EMKIGSIIFQ VASGDITKEE ADVIVNSTSN SFNLKAGVSK 1270 1280 1290 1300 1310 1320 AILECAGQNV ERECSQQAQQ RKNDYIITGG GFLRCKNIIH VIGGNDVKSS VSSVLQECEK 1330 1340 1350 1360 1370 1380 KNYSSICLPA IGTGNAKQHP DKVAEAIIDA IEDFVQKGSA QSVKKVKVVI FLPQVLDVFY 1390 1400 1410 1420 1430 1440 ANMKKREGTQ LSSQQSVMSK LASFLGFSKQ SPQKKNHLVL EKKTESATFR VCGENVTCVE 1450 1460 1470 1480 1490 1500 YAISWLQDLI EKEQCPYTSE DECIKDFDEK EYQELNELQK KLNINISLDH KRPLIKVLGI 1510 1520 1530 1540 1550 1560 SRDVMQARDE IEAMIKRVRL AKEQESRADC ISEFIEWQYN DNNTSHCFNK MTNLKLEDAR 1570 1580 1590 1600 1610 1620 REKKKTVDVK INHRHYTVNL NTYTATDTKG HSLSVQRLTK SKVDIPAHWS DMKQQNFCVV 1630 1640 1650 1660 1670 1680 ELLPSDPEYN TVASKFNQTC SHFRIEKVSL LLECSFWMVE ISSVMVLYKI HFHSLPITFF
	Isoform 5 [UniParc]. Checksum: 978947F6DF05569E	FASTA	797	89,790
	10 20 30 40 50 60 MYLRRLLRPL QMLLVKEGVQ NAKTDVVVNS VPLDLVLSRG PLSKSLLEKA GPELQEELDT 70 80 90 100 110 120 VGQGVAVSMG TVLKTSSWNL DCRYVLHVVA PEWRNGSTSS LKIMEDIIRE CMEITESLSL 130 140 150 160 170 180 KSIAFPAIGT GNLGFPKNIF AELIISEVFK FSSKNQLKTL QEVHFLLHPS DHENIQAFSD 190 200 210 220 230 240 EFARRANGNL VSDKIPKAKD TQGFYGTVSS PDSGVYEMKI GSIIFQVASG DITKEEADVI 250 260 270 280 290 300 VNSTSNSFNL KAGVSKAILE CAGQNVEREC SQQAQQRKND YIITGGGFLR CKNIIHVIGG 310 320 330 340 350 360 NDVKSSVSSV LQECEKKNYS SICLPAIGTG NAKQHPDKVA EAIIDAIEDF VQKGSAQSVK 370 380 390 400 410 420 KVKVVIFLPQ VLDVFYANMK KREGTQLSSQ QSVMSKLASF LGFSKQSPQK KNHLVLEKKT 430 440 450 460 470 480 ESATFRVCGE NVTCVEYAIS WLQDLIEKEQ CPYTSEDECI KDFDEKEYQE LNELQKKLNI 490 500 510 520 530 540 NISLDHKRPL IKVLGISRDV MQARDEIEAM IKRVRLAKEQ ESRADCISEF IEWQYNDNNT 550 560 570 580 590 600 SHCFNKMTNL KLEDARREKK KTVDVKINHR HYTVNLNTYT ATDTKGHSLS VQRLTKSKVD 610 620 630 640 650 660 IPAHWSDMKQ QNFCVVELLP SDPEYNTVAS KFNQTCSHFR IEKIERIQNP DLWNSYQAKK 670 680 690 700 710 720 KTMDAKNGQT MNEKQLFHGT DAGSVPHVNR NGFNRSYAGK NAVAYGKGTY FAVNANYSAN 730 740 750 760 770 780 DTYSRPDANG RKHVYYVRVL TGIYTHGNHS LIVPPSKNPQ NPTDLYDTVT DNVHHPSLFV 790 AFYDYQAYPE YLITFRK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Guo J.H., Yu L. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Ovary.
[2]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1560 (ISOFORMS 1 AND 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1380-1801 (ISOFORMS 1/3/6). Tissue: Ovarian carcinoma, Teratocarcinoma and Trachea.
[4]	"Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes." Kimura K., Wakamatsu A., Suzuki Y., Ota T., Nishikawa T., Yamashita R., Yamamoto J., Sekine M., Tsuritani K., Wakaguri H., Ishii S., Sugiyama T., Saito K., Isono Y., Irie R., Kushida N., Yoneyama T., Otsuka R. , Kanda K., Yokoi T., Kondo H., Wagatsuma M., Murakawa K., Ishida S., Ishibashi T., Takahashi-Fujii A., Tanase T., Nagai K., Kikuchi H., Nakai K., Isogai T., Sugano S. Genome Res. 16:55-65(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-266 (ISOFORM 1). Tissue: Trachea.
[5]	"B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity." Aguiar R.C.T., Takeyama K., He C., Kreinbrink K., Shipp M.A. J. Biol. Chem. 280:33756-33765(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 160-1801 (ISOFORM 4), NUCLEOTIDE SEQUENCE [MRNA] OF 160-1801 (ISOFORM 1), ALTERNATIVE SPLICING, FUNCTION.
[6]	"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O. DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 658-1801 (ISOFORM 4). Tissue: Brain.
[7]	"Toward a unified nomenclature for mammalian ADP-ribosyltransferases." Hottiger M.O., Hassa P.O., Luscher B., Schuler H., Koch-Nolte F. Trends Biochem. Sci. 35:208-219(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NOMENCLATURE.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY134858 mRNA. Translation: AAN08627.1.
AC048348 Genomic DNA. No translation available.
AC092908 Genomic DNA. No translation available.
AK001770 mRNA. Translation: BAA91897.1.
AK022542 mRNA. Translation: BAB14089.1. Different initiation.
AK304269 mRNA. Translation: BAG65132.1.
DB237115 mRNA. No translation available.
DQ063584 mRNA. Translation: AAY64449.1. Different initiation.
DQ063585 mRNA. Translation: AAY64450.1. Different initiation.
AB033094 mRNA. Translation: BAA86582.1.

IPI

IPI00291215.
IPI00783216.
IPI00783683.
IPI00783883.
IPI00784370.

RefSeq

NP_060024.2. NM_017554.2.

UniGene

Hs.518203.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3GOY	X-ray	2.80	A/B/C/D	1611-1801	[»]
3Q6Z	X-ray	2.23	A	789-979	[»]
3Q71	X-ray	2.20	A	999-1196	[»]
3SE2	X-ray	2.30	A/B/C/D	1611-1801	[»]
3SMI	X-ray	2.40	A/B	1611-1801	[»]
3SMJ	X-ray	1.50	A/B	1611-1801	[»]
3VFQ	X-ray	2.80	A	784-1196	[»]
4ABK	X-ray	1.60	A	1208-1388	[»]
4ABL	X-ray	1.15	A	1208-1388	[»]
4D86	X-ray	2.00	A	784-1196	[»]
4F1L	X-ray	1.90	A/B/C/D	1611-1801	[»]
4F1Q	X-ray	2.80	A/B	1611-1801	[»]

ProteinModelPortal

Q460N5.

SMR

Q460N5. Positions 792-978, 999-1191, 1208-1388, 1614-1801.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000311232.

PTM databases

PhosphoSite

Q460N5.

Polymorphism databases

DMDM

110815960.

Proteomic databases

PaxDb

Q460N5.

PRIDE

Q460N5.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000474629; ENSP00000418194; ENSG00000173193.

GeneID

54625.

KEGG

hsa:54625.

UCSC

uc003efq.4. human.
uc003efs.1. human.

Organism-specific databases

CTD

54625.

GeneCards

GC03P122399.

H-InvDB

HIX0019605.

HGNC

HGNC:29232. PARP14.

HPA

HPA008846.
HPA012063.

MIM

610028. gene.

neXtProt

NX_Q460N5.

PharmGKB

PA134861585.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG2110.

HOVERGEN

HBG082105.

InParanoid

Q460N5.

KO

K15261.

OMA

EIFQFLQ.

OrthoDB

EOG4HX505.

Enzyme and pathway databases

BRENDA

2.4.2.30. 2681.

Pathway_Interaction_DB

il4_2pathway. IL4-mediated signaling events.

Gene expression databases

ArrayExpress

Q460N5.

Bgee

Q460N5.

CleanEx

HS_PARP14.

Genevestigator

Q460N5.

GermOnline

ENSG00000173193. Homo sapiens.

Family and domain databases

Gene3D

3.90.228.10. 1 hit.

InterPro

IPR002589. A1pp.
IPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004170. WWE-dom.
[Graphical view]

Pfam

PF01661. Macro. 3 hits.
PF00644. PARP. 1 hit.
PF02825. WWE. 1 hit.
[Graphical view]

SMART

SM00506. A1pp. 3 hits.
[Graphical view]

PROSITE

PS51154. MACRO. 3 hits.
PS51059. PARP_CATALYTIC. 1 hit.
PS50918. WWE. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

PARP14. human.

EvolutionaryTrace

Q460N5.

GenomeRNAi

54625.

NextBio

57162.

SOURCE

Search...

Entry information

Entry name

PAR14_HUMAN

Accession

Primary (citable) accession number: Q460N5
Secondary accession number(s): B4E2H0 , Q460N4, Q8J027, Q9H9X9, Q9NV60, Q9ULF2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	April 5, 2011
Last modified:	May 29, 2013
This is version 75 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.