Reviewed, UniProtKB/Swiss-Prot Q460N5 (PAR14_HUMAN)

Names and origin

Protein names

Recommended name:
    Poly [ADP-ribose] polymerase 14
      Short name=PARP-14
    EC=2.4.2.30
Alternative name(s):
    B aggressive lymphoma protein 2

Gene names

Name:	PARP14
Synonyms:	BAL2, KIAA1268

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1720 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Enhances STAT6-dependent transcription By similarity. Has ADP-ribosyltransferase activity. Ref.1
Catalytic activity	NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
Subunit structure	Interacts with STAT6 By similarity.
Subcellular location	Nucleus. Cytoplasm. Note: In steady state cells the protein is mostly nuclear. A minor proportion is detected in the cytoplasm By similarity.
Sequence similarities	Contains 3 Macro domains. Contains 1 PARP catalytic domain. Contains 1 WWE domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat
Ligand	NAD
Molecular function	Glycosyltransferase Transferase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	regulation of transcription Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from direct assay. Source: HPA nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from direct assay. Source: HPA
Molecular function	NAD+ ADP-ribosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q460N5-1)

Also known as: BAL2B;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q460N5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.
     83-118: FKLTVQLPATPDEIDHVFEEELLTKESKTKEDVKEP → MLILLVENISGLSNDDFQVEIIRDFDVAVVTFQKHI

Isoform 3 (identifier: Q460N5-3)

Also known as: BAL2A;

The sequence of this isoform differs from the canonical sequence as follows:
     1-202: Missing.

Isoform 4 (identifier: Q460N5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.
     83-118: FKLTVQLPATPDEIDHVFEEELLTKESKTKEDVKEP → MLILLVENISGLSNDDFQVEIIRDFDVAVVTFQKHI
     1567-1599: IERIQNPDLWNSYQAKKKTMDAKNGQTMNEKQL → VSLLLECSFWMVEISSVMVLYKIHFHSLPITFF
     1600-1720: Missing.

Isoform 5 (identifier: Q460N5-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-923: Missing.
     924-932: KGSLVSPGG → MYLRRLLRP

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1720

1720

Poly [ADP-ribose] polymerase 14

PRO_0000247589

Regions

Domain

710 – 897

188

Macro 1

Domain

922 – 1109

188

Macro 2

Domain

1135 – 1306

172

Macro 3

Domain

1442 – 1520

79

WWE

Domain

1524 – 1720

197

PARP catalytic

Natural variations

Alternative sequence

1 – 923

923

Missing in isoform 5.

VSP_020013

Alternative sequence

1 – 202

202

Missing in isoform 3.

VSP_020014

Alternative sequence

1 – 82

82

Missing in isoform 2 and isoform 4.

VSP_020015

Alternative sequence

83 – 118

36

FKLTV…DVKEP → MLILLVENISGLSNDDFQVE IIRDFDVAVVTFQKHI in isoform 2 and isoform 4.

VSP_020016

Alternative sequence

924 – 932

9

KGSLVSPGG → MYLRRLLRP in isoform 5.

VSP_020017

Alternative sequence

1567 – 1599

33

IERIQ…NEKQL → VSLLLECSFWMVEISSVMVL YKIHFHSLPITFF in isoform 4.

VSP_020018

Alternative sequence

1600 – 1720

121

Missing in isoform 4.

VSP_020019

Experimental info

Sequence conflict

1158

1

E → G in BAA91897. Ref.3

Sequence conflict

1418

1

G → A in AAN08627. Ref.2

Sequence conflict

1440

1

A → G in AAN08627. Ref.2

Secondary structure

1

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1720

Helix Strand Turn

Details...

Beta strand

1537 – 1540

4

Helix

1546 – 1550

5

Helix

1556 – 1559

4

Beta strand

1564 – 1571

8

Helix

1573 – 1589

17

Beta strand

1596 – 1601

6

Helix

1608 – 1613

6

Beta strand

1633 – 1637

5

Helix

1638 – 1642

5

Turn

1644 – 1646

3

Beta strand

1655 – 1663

9

Beta strand

1682 – 1684

3

Beta strand

1690 – 1694

5

Beta strand

1700 – 1703

4

Beta strand

1709 – 1718

10

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (BAL2B) [UniParc]. Last modified July 25, 2006. Version 2. Checksum: F7EAD232767F2867	FASTA	1,720	193,753
	10 20 30 40 50 60 MAVPGSFPLL VEGSWGPDPP KNLNTKLQMY FQSPKRSGGG ECEVRQDPRS PSRFLVFFYP 70 80 90 100 110 120 EDVRQKVLER KNHELVWQGK GTFKLTVQLP ATPDEIDHVF EEELLTKESK TKEDVKEPDT 130 140 150 160 170 180 IRFVDDCTKH HSIKQLQLSP RLLEVTNTIR VENLPPGADD YSLKLFFENP YNGGGRVANV 190 200 210 220 230 240 EYFPEESSAL IEFFDRKVLD TIMATKLDFN KMPLSVFPYY ASLGTALYGK EKPLIKLPAP 250 260 270 280 290 300 FEESLDLPLW KFLQKKNHLI EEINDEMRRC HCELTWSQLS GKVTIRPAAT LVNEGRPRIK 310 320 330 340 350 360 TWQADTSTTL SSIRSKYKVN PIKVDPTMWD TIKNDVKDDR ILIEFDTLKE MVILAGKSED 370 380 390 400 410 420 VQSIEVQVRE LIESTTQKIK REEQSLKEKM IISPGRYFLL CHSSLLDHLL TECPEIEICY 430 440 450 460 470 480 DRVTQHLCLK GPSADVYKAK CEIQEKVYTM AQKNIQVSPE IFQFLQQVNW KEFSKCLFIA 490 500 510 520 530 540 QKILALYELE GTTVLLTSCS SEALLEAEKQ MLSALNYKRI EVENKEVLHG KKWKGLTHNL 550 560 570 580 590 600 LKKQNSSPNT VIINELTSET TAEVIITGCV KEVNETYKLL FNFVEQNMKI ERLVEVKPSL 610 620 630 640 650 660 VIDYLKTEKK LFWPKIKKVN VQVSFNPENK QKGILLTGSK TEVLKAVDIV KQVWDSVCVK 670 680 690 700 710 720 SVHTDKPGAK QFFQDKARFY QSEIKRLFGC YIELQENEVM KEGGSPAGQK CFSRTVLAPG 730 740 750 760 770 780 VVLIVQQGDL ARLPVDVVVN ASNEDLKHYG GLAAALSKAA GPELQADCDQ IVKREGRLLP 790 800 810 820 830 840 GNATISKAGK LPYHHVIHAV GPRWSGYEAP RCVYLLRRAV QLSLCLAEKY KYRSIAIPAI 850 860 870 880 890 900 SSGVFGFPLG RCVETIVSAI KENFQFKKDG HCLKEIYLVD VSEKTVEAFA EAVKTVFKAT 910 920 930 940 950 960 LPDTAAPPGL PPAAAGPGKT SWEKGSLVSP GGLQMLLVKE GVQNAKTDVV VNSVPLDLVL 970 980 990 1000 1010 1020 SRGPLSKSLL EKAGPELQEE LDTVGQGVAV SMGTVLKTSS WNLDCRYVLH VVAPEWRNGS 1030 1040 1050 1060 1070 1080 TSSLKIMEDI IRECMEITES LSLKSIAFPA IGTGNLGFPK NIFAELIISE VFKFSSKNQL 1090 1100 1110 1120 1130 1140 KTLQEVHFLL HPSDHENIQA FSDEFARRAN GNLVSDKIPK AKDTQGFYGT VSSPDSGVYE 1150 1160 1170 1180 1190 1200 MKIGSIIFQV ASGDITKEEA DVIVNSTSNS FNLKAGVSKA ILECAGQNVE RECSQQAQQR 1210 1220 1230 1240 1250 1260 KNDYIITGGG FLRCKNIIHV IGGNDVKSSV SSVLQECEKK NYSSICLPAI GTGNAKQHPD 1270 1280 1290 1300 1310 1320 KVAEAIIDAI EDFVQKGSAQ SVKKVKVVIF LPQVLDVFYA NMKKREGTQL SSQQSVMSKL 1330 1340 1350 1360 1370 1380 ASFLGFSKQS PQKKNHLVLE KKTESATFRV CGENVTCVEY AISWLQDLIE KEQCPYTSED 1390 1400 1410 1420 1430 1440 ECIKDFDEKE YQELNELQKK LNINISLDHK RPLIKVLGIS RDVMQARDEI EAMIKRVRLA 1450 1460 1470 1480 1490 1500 KEQESRADCI SEFIEWQYND NNTSHCFNKM TNLKLEDARR EKKKTVDVKI NHRHYTVNLN 1510 1520 1530 1540 1550 1560 TYTATDTKGH SLSVQRLTKS KVDIPAHWSD MKQQNFCVVE LLPSDPEYNT VASKFNQTCS 1570 1580 1590 1600 1610 1620 HFRIEKIERI QNPDLWNSYQ AKKKTMDAKN GQTMNEKQLF HGTDAGSVPH VNRNGFNRSY 1630 1640 1650 1660 1670 1680 AGKNAVAYGK GTYFAVNANY SANDTYSRPD ANGRKHVYYV RVLTGIYTHG NHSLIVPPSK 1690 1700 1710 1720 NPQNPTDLYD TVTDNVHHPS LFVAFYDYQA YPEYLITFRK
	Isoform 2. Checksum: 64C7926C05848EFB	FASTA	1,638	184,342
	10 20 30 40 50 60 MLILLVENIS GLSNDDFQVE IIRDFDVAVV TFQKHIDTIR FVDDCTKHHS IKQLQLSPRL 70 80 90 100 110 120 LEVTNTIRVE NLPPGADDYS LKLFFENPYN GGGRVANVEY FPEESSALIE FFDRKVLDTI 130 140 150 160 170 180 MATKLDFNKM PLSVFPYYAS LGTALYGKEK PLIKLPAPFE ESLDLPLWKF LQKKNHLIEE 190 200 210 220 230 240 INDEMRRCHC ELTWSQLSGK VTIRPAATLV NEGRPRIKTW QADTSTTLSS IRSKYKVNPI 250 260 270 280 290 300 KVDPTMWDTI KNDVKDDRIL IEFDTLKEMV ILAGKSEDVQ SIEVQVRELI ESTTQKIKRE 310 320 330 340 350 360 EQSLKEKMII SPGRYFLLCH SSLLDHLLTE CPEIEICYDR VTQHLCLKGP SADVYKAKCE 370 380 390 400 410 420 IQEKVYTMAQ KNIQVSPEIF QFLQQVNWKE FSKCLFIAQK ILALYELEGT TVLLTSCSSE 430 440 450 460 470 480 ALLEAEKQML SALNYKRIEV ENKEVLHGKK WKGLTHNLLK KQNSSPNTVI INELTSETTA 490 500 510 520 530 540 EVIITGCVKE VNETYKLLFN FVEQNMKIER LVEVKPSLVI DYLKTEKKLF WPKIKKVNVQ 550 560 570 580 590 600 VSFNPENKQK GILLTGSKTE VLKAVDIVKQ VWDSVCVKSV HTDKPGAKQF FQDKARFYQS 610 620 630 640 650 660 EIKRLFGCYI ELQENEVMKE GGSPAGQKCF SRTVLAPGVV LIVQQGDLAR LPVDVVVNAS 670 680 690 700 710 720 NEDLKHYGGL AAALSKAAGP ELQADCDQIV KREGRLLPGN ATISKAGKLP YHHVIHAVGP 730 740 750 760 770 780 RWSGYEAPRC VYLLRRAVQL SLCLAEKYKY RSIAIPAISS GVFGFPLGRC VETIVSAIKE 790 800 810 820 830 840 NFQFKKDGHC LKEIYLVDVS EKTVEAFAEA VKTVFKATLP DTAAPPGLPP AAAGPGKTSW 850 860 870 880 890 900 EKGSLVSPGG LQMLLVKEGV QNAKTDVVVN SVPLDLVLSR GPLSKSLLEK AGPELQEELD 910 920 930 940 950 960 TVGQGVAVSM GTVLKTSSWN LDCRYVLHVV APEWRNGSTS SLKIMEDIIR ECMEITESLS 970 980 990 1000 1010 1020 LKSIAFPAIG TGNLGFPKNI FAELIISEVF KFSSKNQLKT LQEVHFLLHP SDHENIQAFS 1030 1040 1050 1060 1070 1080 DEFARRANGN LVSDKIPKAK DTQGFYGTVS SPDSGVYEMK IGSIIFQVAS GDITKEEADV 1090 1100 1110 1120 1130 1140 IVNSTSNSFN LKAGVSKAIL ECAGQNVERE CSQQAQQRKN DYIITGGGFL RCKNIIHVIG 1150 1160 1170 1180 1190 1200 GNDVKSSVSS VLQECEKKNY SSICLPAIGT GNAKQHPDKV AEAIIDAIED FVQKGSAQSV 1210 1220 1230 1240 1250 1260 KKVKVVIFLP QVLDVFYANM KKREGTQLSS QQSVMSKLAS FLGFSKQSPQ KKNHLVLEKK 1270 1280 1290 1300 1310 1320 TESATFRVCG ENVTCVEYAI SWLQDLIEKE QCPYTSEDEC IKDFDEKEYQ ELNELQKKLN 1330 1340 1350 1360 1370 1380 INISLDHKRP LIKVLGISRD VMQARDEIEA MIKRVRLAKE QESRADCISE FIEWQYNDNN 1390 1400 1410 1420 1430 1440 TSHCFNKMTN LKLEDARREK KKTVDVKINH RHYTVNLNTY TATDTKGHSL SVQRLTKSKV 1450 1460 1470 1480 1490 1500 DIPAHWSDMK QQNFCVVELL PSDPEYNTVA SKFNQTCSHF RIEKIERIQN PDLWNSYQAK 1510 1520 1530 1540 1550 1560 KKTMDAKNGQ TMNEKQLFHG TDAGSVPHVN RNGFNRSYAG KNAVAYGKGT YFAVNANYSA 1570 1580 1590 1600 1610 1620 NDTYSRPDAN GRKHVYYVRV LTGIYTHGNH SLIVPPSKNP QNPTDLYDTV TDNVHHPSLF 1630 VAFYDYQAYP EYLITFRK
	Isoform 3 (BAL2A). Checksum: 8B8D7BFCB9682902	FASTA	1,518	170,601
	10 20 30 40 50 60 MATKLDFNKM PLSVFPYYAS LGTALYGKEK PLIKLPAPFE ESLDLPLWKF LQKKNHLIEE 70 80 90 100 110 120 INDEMRRCHC ELTWSQLSGK VTIRPAATLV NEGRPRIKTW QADTSTTLSS IRSKYKVNPI 130 140 150 160 170 180 KVDPTMWDTI KNDVKDDRIL IEFDTLKEMV ILAGKSEDVQ SIEVQVRELI ESTTQKIKRE 190 200 210 220 230 240 EQSLKEKMII SPGRYFLLCH SSLLDHLLTE CPEIEICYDR VTQHLCLKGP SADVYKAKCE 250 260 270 280 290 300 IQEKVYTMAQ KNIQVSPEIF QFLQQVNWKE FSKCLFIAQK ILALYELEGT TVLLTSCSSE 310 320 330 340 350 360 ALLEAEKQML SALNYKRIEV ENKEVLHGKK WKGLTHNLLK KQNSSPNTVI INELTSETTA 370 380 390 400 410 420 EVIITGCVKE VNETYKLLFN FVEQNMKIER LVEVKPSLVI DYLKTEKKLF WPKIKKVNVQ 430 440 450 460 470 480 VSFNPENKQK GILLTGSKTE VLKAVDIVKQ VWDSVCVKSV HTDKPGAKQF FQDKARFYQS 490 500 510 520 530 540 EIKRLFGCYI ELQENEVMKE GGSPAGQKCF SRTVLAPGVV LIVQQGDLAR LPVDVVVNAS 550 560 570 580 590 600 NEDLKHYGGL AAALSKAAGP ELQADCDQIV KREGRLLPGN ATISKAGKLP YHHVIHAVGP 610 620 630 640 650 660 RWSGYEAPRC VYLLRRAVQL SLCLAEKYKY RSIAIPAISS GVFGFPLGRC VETIVSAIKE 670 680 690 700 710 720 NFQFKKDGHC LKEIYLVDVS EKTVEAFAEA VKTVFKATLP DTAAPPGLPP AAAGPGKTSW 730 740 750 760 770 780 EKGSLVSPGG LQMLLVKEGV QNAKTDVVVN SVPLDLVLSR GPLSKSLLEK AGPELQEELD 790 800 810 820 830 840 TVGQGVAVSM GTVLKTSSWN LDCRYVLHVV APEWRNGSTS SLKIMEDIIR ECMEITESLS 850 860 870 880 890 900 LKSIAFPAIG TGNLGFPKNI FAELIISEVF KFSSKNQLKT LQEVHFLLHP SDHENIQAFS 910 920 930 940 950 960 DEFARRANGN LVSDKIPKAK DTQGFYGTVS SPDSGVYEMK IGSIIFQVAS GDITKEEADV 970 980 990 1000 1010 1020 IVNSTSNSFN LKAGVSKAIL ECAGQNVERE CSQQAQQRKN DYIITGGGFL RCKNIIHVIG 1030 1040 1050 1060 1070 1080 GNDVKSSVSS VLQECEKKNY SSICLPAIGT GNAKQHPDKV AEAIIDAIED FVQKGSAQSV 1090 1100 1110 1120 1130 1140 KKVKVVIFLP QVLDVFYANM KKREGTQLSS QQSVMSKLAS FLGFSKQSPQ KKNHLVLEKK 1150 1160 1170 1180 1190 1200 TESATFRVCG ENVTCVEYAI SWLQDLIEKE QCPYTSEDEC IKDFDEKEYQ ELNELQKKLN 1210 1220 1230 1240 1250 1260 INISLDHKRP LIKVLGISRD VMQARDEIEA MIKRVRLAKE QESRADCISE FIEWQYNDNN 1270 1280 1290 1300 1310 1320 TSHCFNKMTN LKLEDARREK KKTVDVKINH RHYTVNLNTY TATDTKGHSL SVQRLTKSKV 1330 1340 1350 1360 1370 1380 DIPAHWSDMK QQNFCVVELL PSDPEYNTVA SKFNQTCSHF RIEKIERIQN PDLWNSYQAK 1390 1400 1410 1420 1430 1440 KKTMDAKNGQ TMNEKQLFHG TDAGSVPHVN RNGFNRSYAG KNAVAYGKGT YFAVNANYSA 1450 1460 1470 1480 1490 1500 NDTYSRPDAN GRKHVYYVRV LTGIYTHGNH SLIVPPSKNP QNPTDLYDTV TDNVHHPSLF 1510 VAFYDYQAYP EYLITFRK
	Isoform 4. Checksum: 9924631967659961	FASTA	1,517	170,719
	10 20 30 40 50 60 MLILLVENIS GLSNDDFQVE IIRDFDVAVV TFQKHIDTIR FVDDCTKHHS IKQLQLSPRL 70 80 90 100 110 120 LEVTNTIRVE NLPPGADDYS LKLFFENPYN GGGRVANVEY FPEESSALIE FFDRKVLDTI 130 140 150 160 170 180 MATKLDFNKM PLSVFPYYAS LGTALYGKEK PLIKLPAPFE ESLDLPLWKF LQKKNHLIEE 190 200 210 220 230 240 INDEMRRCHC ELTWSQLSGK VTIRPAATLV NEGRPRIKTW QADTSTTLSS IRSKYKVNPI 250 260 270 280 290 300 KVDPTMWDTI KNDVKDDRIL IEFDTLKEMV ILAGKSEDVQ SIEVQVRELI ESTTQKIKRE 310 320 330 340 350 360 EQSLKEKMII SPGRYFLLCH SSLLDHLLTE CPEIEICYDR VTQHLCLKGP SADVYKAKCE 370 380 390 400 410 420 IQEKVYTMAQ KNIQVSPEIF QFLQQVNWKE FSKCLFIAQK ILALYELEGT TVLLTSCSSE 430 440 450 460 470 480 ALLEAEKQML SALNYKRIEV ENKEVLHGKK WKGLTHNLLK KQNSSPNTVI INELTSETTA 490 500 510 520 530 540 EVIITGCVKE VNETYKLLFN FVEQNMKIER LVEVKPSLVI DYLKTEKKLF WPKIKKVNVQ 550 560 570 580 590 600 VSFNPENKQK GILLTGSKTE VLKAVDIVKQ VWDSVCVKSV HTDKPGAKQF FQDKARFYQS 610 620 630 640 650 660 EIKRLFGCYI ELQENEVMKE GGSPAGQKCF SRTVLAPGVV LIVQQGDLAR LPVDVVVNAS 670 680 690 700 710 720 NEDLKHYGGL AAALSKAAGP ELQADCDQIV KREGRLLPGN ATISKAGKLP YHHVIHAVGP 730 740 750 760 770 780 RWSGYEAPRC VYLLRRAVQL SLCLAEKYKY RSIAIPAISS GVFGFPLGRC VETIVSAIKE 790 800 810 820 830 840 NFQFKKDGHC LKEIYLVDVS EKTVEAFAEA VKTVFKATLP DTAAPPGLPP AAAGPGKTSW 850 860 870 880 890 900 EKGSLVSPGG LQMLLVKEGV QNAKTDVVVN SVPLDLVLSR GPLSKSLLEK AGPELQEELD 910 920 930 940 950 960 TVGQGVAVSM GTVLKTSSWN LDCRYVLHVV APEWRNGSTS SLKIMEDIIR ECMEITESLS 970 980 990 1000 1010 1020 LKSIAFPAIG TGNLGFPKNI FAELIISEVF KFSSKNQLKT LQEVHFLLHP SDHENIQAFS 1030 1040 1050 1060 1070 1080 DEFARRANGN LVSDKIPKAK DTQGFYGTVS SPDSGVYEMK IGSIIFQVAS GDITKEEADV 1090 1100 1110 1120 1130 1140 IVNSTSNSFN LKAGVSKAIL ECAGQNVERE CSQQAQQRKN DYIITGGGFL RCKNIIHVIG 1150 1160 1170 1180 1190 1200 GNDVKSSVSS VLQECEKKNY SSICLPAIGT GNAKQHPDKV AEAIIDAIED FVQKGSAQSV 1210 1220 1230 1240 1250 1260 KKVKVVIFLP QVLDVFYANM KKREGTQLSS QQSVMSKLAS FLGFSKQSPQ KKNHLVLEKK 1270 1280 1290 1300 1310 1320 TESATFRVCG ENVTCVEYAI SWLQDLIEKE QCPYTSEDEC IKDFDEKEYQ ELNELQKKLN 1330 1340 1350 1360 1370 1380 INISLDHKRP LIKVLGISRD VMQARDEIEA MIKRVRLAKE QESRADCISE FIEWQYNDNN 1390 1400 1410 1420 1430 1440 TSHCFNKMTN LKLEDARREK KKTVDVKINH RHYTVNLNTY TATDTKGHSL SVQRLTKSKV 1450 1460 1470 1480 1490 1500 DIPAHWSDMK QQNFCVVELL PSDPEYNTVA SKFNQTCSHF RIEKVSLLLE CSFWMVEISS 1510 VMVLYKIHFH SLPITFF
	Isoform 5. Checksum: 978947F6DF05569E	FASTA	797	89,790
	10 20 30 40 50 60 MYLRRLLRPL QMLLVKEGVQ NAKTDVVVNS VPLDLVLSRG PLSKSLLEKA GPELQEELDT 70 80 90 100 110 120 VGQGVAVSMG TVLKTSSWNL DCRYVLHVVA PEWRNGSTSS LKIMEDIIRE CMEITESLSL 130 140 150 160 170 180 KSIAFPAIGT GNLGFPKNIF AELIISEVFK FSSKNQLKTL QEVHFLLHPS DHENIQAFSD 190 200 210 220 230 240 EFARRANGNL VSDKIPKAKD TQGFYGTVSS PDSGVYEMKI GSIIFQVASG DITKEEADVI 250 260 270 280 290 300 VNSTSNSFNL KAGVSKAILE CAGQNVEREC SQQAQQRKND YIITGGGFLR CKNIIHVIGG 310 320 330 340 350 360 NDVKSSVSSV LQECEKKNYS SICLPAIGTG NAKQHPDKVA EAIIDAIEDF VQKGSAQSVK 370 380 390 400 410 420 KVKVVIFLPQ VLDVFYANMK KREGTQLSSQ QSVMSKLASF LGFSKQSPQK KNHLVLEKKT 430 440 450 460 470 480 ESATFRVCGE NVTCVEYAIS WLQDLIEKEQ CPYTSEDECI KDFDEKEYQE LNELQKKLNI 490 500 510 520 530 540 NISLDHKRPL IKVLGISRDV MQARDEIEAM IKRVRLAKEQ ESRADCISEF IEWQYNDNNT 550 560 570 580 590 600 SHCFNKMTNL KLEDARREKK KTVDVKINHR HYTVNLNTYT ATDTKGHSLS VQRLTKSKVD 610 620 630 640 650 660 IPAHWSDMKQ QNFCVVELLP SDPEYNTVAS KFNQTCSHFR IEKIERIQNP DLWNSYQAKK 670 680 690 700 710 720 KTMDAKNGQT MNEKQLFHGT DAGSVPHVNR NGFNRSYAGK NAVAYGKGTY FAVNANYSAN 730 740 750 760 770 780 DTYSRPDANG RKHVYYVRVL TGIYTHGNHS LIVPPSKNPQ NPTDLYDTVT DNVHHPSLFV 790 AFYDYQAYPE YLITFRK

References

[1]	"B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity." Aguiar R.C.T., Takeyama K., He C., Kreinbrink K., Shipp M.A. J. Biol. Chem. 280:33756-33765(2005) [PubMed: 16061477] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4), ALTERNATIVE SPLICING, FUNCTION.
[2]	Guo J.H., Yu L. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Ovary.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-185 AND 1299-1720 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1479 (ISOFORM 5). Tissue: Ovarian carcinoma, Teratocarcinoma and Trachea.
[4]	"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O. DNA Res. 6:337-345(1999) [PubMed: 10574462] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 577-1720 (ISOFORM 4). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

DQ063584 mRNA. Translation: AAY64449.1.
DQ063585 mRNA. Translation: AAY64450.1.
AY134858 mRNA. Translation: AAN08627.1.
AK001770 mRNA. Translation: BAA91897.1.
AK022542 mRNA. Translation: BAB14089.1. Different initiation.
DB237115 mRNA. No translation available.
AB033094 mRNA. Translation: BAA86582.1.

IPI

IPI00291215.
IPI00783216.
IPI00783683.
IPI00783883.
IPI00784370.

RefSeq

NP_060024.2.

UniGene

Hs.518203

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3GOY	X-ray	2.80	A/B/C/D	1530-1720	[»]

SMR

Q460N5. Positions 708-897, 875-1081, 937-1108, 1386-1719.

ModBase

Search...

Protein-protein interaction databases

STRING

Q460N5.

PTM databases

PhosphoSite

Q460N5.

Proteomic databases

PRIDE

Q460N5.

Genome annotation databases

Ensembl

ENST00000398162; ENSP00000381228; ENSG00000173193; Homo sapiens. [Genome view]

GeneID

54625.

KEGG

hsa:54625.

UCSC

uc003efq.2. human.
uc003efs.1. human.

Organism-specific databases

CTD

54625.

GeneCards

GC03P123897.

H-InvDB

HIX0019605.

HGNC

HGNC:29232. PARP14.

HPA

HPA008846.
HPA012063.

MIM

610028. gene.

PharmGKB

PA134861585.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG19122.

HOVERGEN

Q460N5.

InParanoid

Q460N5.

Enzyme and pathway databases

BRENDA

2.4.2.30. 247.

Pathway_Interaction_DB

il4_2pathway. IL4-mediated signaling events.

Gene expression databases

ArrayExpress

Q460N5.

Bgee

Q460N5.

CleanEx

HS_PARP14.

Genevestigator

Q460N5.

GermOnline

ENSG00000173193. Homo sapiens.

Family and domain databases

InterPro

IPR002589. A1pp.
IPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004170. WWE-dom.
[Graphical view]

Pfam

PF01661. Macro. 3 hits.
PF00644. PARP. 1 hit.
PF02825. WWE. 1 hit.
[Graphical view]

SMART

SM00506. A1pp. 3 hits.
[Graphical view]

PROSITE

PS51154. MACRO. 3 hits.
PS51059. PARP_CATALYTIC. 1 hit.
PS50918. WWE. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

57162.

SOURCE

Search...

Entry information

Entry name

PAR14_HUMAN

Accession

Primary (citable) accession number: Q460N5
Secondary accession number(s): Q460N4 , Q8J027, Q9H9X9, Q9NV60, Q9ULF2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	July 25, 2006
Last modified:	January 19, 2010
This is version 43 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.