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Protein

Poly [ADP-ribose] polymerase 15

Gene

PARP15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Possesses ADP-ribosyltransferase activity (PubMed:16061477, PubMed:25635049). Transcriptional repressor (PubMed:16061477).2 Publications

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei331SubstrateCombined sources1 Publication1
Binding sitei335Substrate; via amide nitrogenCombined sources1 Publication1
Binding sitei449SubstrateCombined sources1 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processTranscription, Transcription regulation
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Poly [ADP-ribose] polymerase 15 (EC:2.4.2.301 Publication)
Short name:
PARP-15
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 7
Short name:
ARTD7
B-aggressive lymphoma protein 3
Gene namesi
Name:PARP15
Synonyms:BAL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:26876. PARP15.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi559H → Y: Abolishes catalytic activity. 1 Publication1
Mutagenesisi560G → A: Slightly reduces catalytic activity. Abolishes activity; when associated with Y-559 and C-604. 1 Publication1
Mutagenesisi604Y → C: Reduces catalytic activity 20-fold. Abolishes activity; when associated with Y-559 and A-560. 1 Publication1

Organism-specific databases

DisGeNETi165631.
OpenTargetsiENSG00000173200.
PharmGKBiPA134905094.

Chemistry databases

ChEMBLiCHEMBL2176778.

Polymorphism and mutation databases

BioMutaiPARP15.
DMDMi116248564.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002524361 – 678Poly [ADP-ribose] polymerase 15Add BLAST678

Proteomic databases

PaxDbiQ460N3.
PeptideAtlasiQ460N3.
PRIDEiQ460N3.

PTM databases

iPTMnetiQ460N3.
PhosphoSitePlusiQ460N3.

Expressioni

Gene expression databases

BgeeiENSG00000173200.
CleanExiHS_PARP15.
ExpressionAtlasiQ460N3. baseline and differential.
GenevisibleiQ460N3. HS.

Organism-specific databases

HPAiHPA075786.

Interactioni

Protein-protein interaction databases

BioGridi127917. 1 interactor.
STRINGi9606.ENSP00000417214.

Chemistry databases

BindingDBiQ460N3.

Structurei

Secondary structure

1678
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi296 – 301Combined sources6
Beta strandi304 – 311Combined sources8
Helixi313 – 315Combined sources3
Beta strandi318 – 325Combined sources8
Helixi335 – 343Combined sources9
Helixi345 – 355Combined sources11
Beta strandi361 – 366Combined sources6
Beta strandi370 – 379Combined sources10
Helixi384 – 397Combined sources14
Beta strandi402 – 405Combined sources4
Helixi417 – 434Combined sources18
Beta strandi442 – 449Combined sources8
Helixi451 – 461Combined sources11
Beta strandi493 – 498Combined sources6
Helixi504 – 517Combined sources14
Beta strandi520 – 530Combined sources11
Helixi531 – 547Combined sources17
Beta strandi548 – 550Combined sources3
Beta strandi554 – 561Combined sources8
Helixi563 – 565Combined sources3
Helixi566 – 572Combined sources7
Turni576 – 578Combined sources3
Beta strandi588 – 595Combined sources8
Helixi596 – 600Combined sources5
Turni602 – 604Combined sources3
Beta strandi613 – 621Combined sources9
Beta strandi624 – 627Combined sources4
Beta strandi637 – 639Combined sources3
Beta strandi642 – 646Combined sources5
Beta strandi648 – 652Combined sources5
Beta strandi654 – 656Combined sources3
Beta strandi658 – 662Combined sources5
Beta strandi667 – 677Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BLJX-ray2.20A/B481-678[»]
3GEYX-ray2.20A/B/C/D481-678[»]
3V2BX-ray2.20A295-470[»]
4F0EX-ray2.40A/B/C/D481-678[»]
ProteinModelPortaliQ460N3.
SMRiQ460N3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ460N3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 267Macro 1PROSITE-ProRule annotationAdd BLAST190
Domaini293 – 464Macro 2PROSITE-ProRule annotationAdd BLAST172
Domaini482 – 678PARP catalyticPROSITE-ProRule annotationAdd BLAST197

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni312 – 313Substrate bindingCombined sources1 Publication2
Regioni324 – 325Substrate bindingCombined sources1 Publication2
Regioni409 – 413Substrate bindingCombined sources1 Publication5

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2633. Eukaryota.
COG2110. LUCA.
GeneTreeiENSGT00760000119084.
HOGENOMiHOG000026781.
HOVERGENiHBG082106.
InParanoidiQ460N3.
KOiK15261.
OMAiFPMIGTG.
OrthoDBiEOG091G00EB.
PhylomeDBiQ460N3.

Family and domain databases

Gene3Di3.90.228.10. 1 hit.
InterProiView protein in InterPro
IPR002589. Macro_dom.
IPR012317. Poly(ADP-ribose)pol_cat_dom.
PfamiView protein in Pfam
PF01661. Macro. 2 hits.
PF00644. PARP. 1 hit.
SMARTiView protein in SMART
SM00506. A1pp. 2 hits.
PROSITEiView protein in PROSITE
PS51154. MACRO. 2 hits.
PS51059. PARP_CATALYTIC. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q460N3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPGPLPAA ALSPGAPTPR ELMHGVAGVT SRAGRDREAG SVLPAGNRGA
60 70 80 90 100
RKASRRSSSR SMSRDNKFSK KDCLSIRNVV ASIQTKEGLN LKLISGDVLY
110 120 130 140 150
IWADVIVNSV PMNLQLGGGP LSRAFLQKAG PMLQKELDDR RRETEEKVGN
160 170 180 190 200
IFMTSGCNLD CKAVLHAVAP YWNNGAETSW QIMANIIKKC LTTVEVLSFS
210 220 230 240 250
SITFPMIGTG SLQFPKAVFA KLILSEVFEY SSSTRPITSP LQEVHFLVYT
260 270 280 290 300
NDDEGCQAFL DEFTNWSRIN PNKARIPMAG DTQGVVGTVS KPCFTAYEMK
310 320 330 340 350
IGAITFQVAT GDIATEQVDV IVNSTARTFN RKSGVSRAIL EGAGQAVESE
360 370 380 390 400
CAVLAAQPHR DFIITPGGCL KCKIIIHVPG GKDVRKTVTS VLEECEQRKY
410 420 430 440 450
TSVSLPAIGT GNAGKNPITV ADNIIDAIVD FSSQHSTPSL KTVKVVIFQP
460 470 480 490 500
ELLNIFYDSM KKRDLSASLN FQSTFSMTTC NLPEHWTDMN HQLFCMVQLE
510 520 530 540 550
PGQSEYNTIK DKFTRTCSSY AIEKIERIQN AFLWQSYQVK KRQMDIKNDH
560 570 580 590 600
KNNERLLFHG TDADSVPYVN QHGFNRSCAG KNAVSYGKGT YFAVDASYSA
610 620 630 640 650
KDTYSKPDSN GRKHMYVVRV LTGVFTKGRA GLVTPPPKNP HNPTDLFDSV
660 670
TNNTRSPKLF VVFFDNQAYP EYLITFTA
Length:678
Mass (Da):74,576
Last modified:April 16, 2014 - v2
Checksum:iE299386DA4B2BF8C
GO
Isoform 2 (identifier: Q460N3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-234: Missing.
     235-256: RPITSPLQEVHFLVYTNDDEGC → MLQRIGLIFLHNIVVVSNCFYF

Show »
Length:444
Mass (Da):49,501
Checksum:i1A86C67A336419FC
GO

Sequence cautioni

The sequence AAY64451 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42V → M in AAY64451 (PubMed:16061477).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027862337R → K. Corresponds to variant dbSNP:rs6793271Ensembl.1
Natural variantiVAR_056658521A → T. Corresponds to variant dbSNP:rs34383355Ensembl.1
Natural variantiVAR_027863628G → R. Corresponds to variant dbSNP:rs12489170Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0209711 – 234Missing in isoform 2. 2 PublicationsAdd BLAST234
Alternative sequenceiVSP_020972235 – 256RPITS…DDEGC → MLQRIGLIFLHNIVVVSNCF YF in isoform 2. 2 PublicationsAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097916 mRNA. Translation: BAC05197.1.
BC101703 mRNA. Translation: AAI01704.1.
BC101701 mRNA. Translation: AAI01702.1.
AC092908 Genomic DNA. No translation available.
DQ063586 mRNA. Translation: AAY64451.1. Different initiation.
CCDSiCCDS3016.1. [Q460N3-2]
CCDS46893.1. [Q460N3-1]
RefSeqiNP_001106995.1. NM_001113523.2. [Q460N3-1]
NP_001295249.1. NM_001308320.1.
NP_689828.1. NM_152615.2. [Q460N3-2]
UniGeneiHs.120250.

Genome annotation databases

EnsembliENST00000310366; ENSP00000308436; ENSG00000173200. [Q460N3-2]
ENST00000464300; ENSP00000417214; ENSG00000173200. [Q460N3-1]
GeneIDi165631.
KEGGihsa:165631.
UCSCiuc003efm.3. human. [Q460N3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097916 mRNA. Translation: BAC05197.1.
BC101703 mRNA. Translation: AAI01704.1.
BC101701 mRNA. Translation: AAI01702.1.
AC092908 Genomic DNA. No translation available.
DQ063586 mRNA. Translation: AAY64451.1. Different initiation.
CCDSiCCDS3016.1. [Q460N3-2]
CCDS46893.1. [Q460N3-1]
RefSeqiNP_001106995.1. NM_001113523.2. [Q460N3-1]
NP_001295249.1. NM_001308320.1.
NP_689828.1. NM_152615.2. [Q460N3-2]
UniGeneiHs.120250.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BLJX-ray2.20A/B481-678[»]
3GEYX-ray2.20A/B/C/D481-678[»]
3V2BX-ray2.20A295-470[»]
4F0EX-ray2.40A/B/C/D481-678[»]
ProteinModelPortaliQ460N3.
SMRiQ460N3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127917. 1 interactor.
STRINGi9606.ENSP00000417214.

Chemistry databases

BindingDBiQ460N3.
ChEMBLiCHEMBL2176778.

PTM databases

iPTMnetiQ460N3.
PhosphoSitePlusiQ460N3.

Polymorphism and mutation databases

BioMutaiPARP15.
DMDMi116248564.

Proteomic databases

PaxDbiQ460N3.
PeptideAtlasiQ460N3.
PRIDEiQ460N3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310366; ENSP00000308436; ENSG00000173200. [Q460N3-2]
ENST00000464300; ENSP00000417214; ENSG00000173200. [Q460N3-1]
GeneIDi165631.
KEGGihsa:165631.
UCSCiuc003efm.3. human. [Q460N3-1]

Organism-specific databases

CTDi165631.
DisGeNETi165631.
GeneCardsiPARP15.
H-InvDBHIX0200519.
HGNCiHGNC:26876. PARP15.
HPAiHPA075786.
MIMi612066. gene.
neXtProtiNX_Q460N3.
OpenTargetsiENSG00000173200.
PharmGKBiPA134905094.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2633. Eukaryota.
COG2110. LUCA.
GeneTreeiENSGT00760000119084.
HOGENOMiHOG000026781.
HOVERGENiHBG082106.
InParanoidiQ460N3.
KOiK15261.
OMAiFPMIGTG.
OrthoDBiEOG091G00EB.
PhylomeDBiQ460N3.

Miscellaneous databases

ChiTaRSiPARP15. human.
EvolutionaryTraceiQ460N3.
GenomeRNAii165631.
PROiQ460N3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173200.
CleanExiHS_PARP15.
ExpressionAtlasiQ460N3. baseline and differential.
GenevisibleiQ460N3. HS.

Family and domain databases

Gene3Di3.90.228.10. 1 hit.
InterProiView protein in InterPro
IPR002589. Macro_dom.
IPR012317. Poly(ADP-ribose)pol_cat_dom.
PfamiView protein in Pfam
PF01661. Macro. 2 hits.
PF00644. PARP. 1 hit.
SMARTiView protein in SMART
SM00506. A1pp. 2 hits.
PROSITEiView protein in PROSITE
PS51154. MACRO. 2 hits.
PS51059. PARP_CATALYTIC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPAR15_HUMAN
AccessioniPrimary (citable) accession number: Q460N3
Secondary accession number(s): J3KR47, Q8N1K3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: April 16, 2014
Last modified: February 15, 2017
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.