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Protein

Poly [ADP-ribose] polymerase 15

Gene

PARP15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor. Has ADP-ribosyltransferase activity.1 Publication

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Poly [ADP-ribose] polymerase 15 (EC:2.4.2.30)
Short name:
PARP-15
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 7
Short name:
ARTD7
B-aggressive lymphoma protein 3
Gene namesi
Name:PARP15
Synonyms:BAL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:26876. PARP15.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134905094.

Chemistry

ChEMBLiCHEMBL2176778.

Polymorphism and mutation databases

BioMutaiPARP15.
DMDMi116248564.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 678678Poly [ADP-ribose] polymerase 15PRO_0000252436Add
BLAST

Proteomic databases

PaxDbiQ460N3.
PRIDEiQ460N3.

PTM databases

iPTMnetiQ460N3.
PhosphoSiteiQ460N3.

Expressioni

Gene expression databases

BgeeiQ460N3.
CleanExiHS_PARP15.
ExpressionAtlasiQ460N3. baseline and differential.
GenevisibleiQ460N3. HS.

Interactioni

Protein-protein interaction databases

BioGridi127917. 1 interaction.
STRINGi9606.ENSP00000417214.

Structurei

Secondary structure

1
678
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi296 – 3016Combined sources
Beta strandi304 – 3118Combined sources
Helixi313 – 3153Combined sources
Beta strandi318 – 3258Combined sources
Helixi335 – 3439Combined sources
Helixi345 – 35511Combined sources
Beta strandi361 – 3666Combined sources
Beta strandi370 – 37910Combined sources
Helixi384 – 39714Combined sources
Beta strandi402 – 4054Combined sources
Helixi417 – 43418Combined sources
Beta strandi442 – 4498Combined sources
Helixi451 – 46111Combined sources
Beta strandi493 – 4986Combined sources
Helixi504 – 51714Combined sources
Beta strandi520 – 53011Combined sources
Helixi531 – 54717Combined sources
Beta strandi548 – 5503Combined sources
Beta strandi554 – 5618Combined sources
Helixi563 – 5653Combined sources
Helixi566 – 5727Combined sources
Turni576 – 5783Combined sources
Beta strandi588 – 5958Combined sources
Helixi596 – 6005Combined sources
Turni602 – 6043Combined sources
Beta strandi613 – 6219Combined sources
Beta strandi624 – 6274Combined sources
Beta strandi637 – 6393Combined sources
Beta strandi642 – 6465Combined sources
Beta strandi648 – 6525Combined sources
Beta strandi654 – 6563Combined sources
Beta strandi658 – 6625Combined sources
Beta strandi667 – 67711Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3BLJX-ray2.20A/B481-678[»]
3GEYX-ray2.20A/B/C/D481-678[»]
3V2BX-ray2.20A295-470[»]
4F0EX-ray2.40A/B/C/D481-678[»]
ProteinModelPortaliQ460N3.
SMRiQ460N3. Positions 51-465, 481-678.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ460N3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini78 – 267190Macro 1PROSITE-ProRule annotationAdd
BLAST
Domaini293 – 464172Macro 2PROSITE-ProRule annotationAdd
BLAST
Domaini482 – 678197PARP catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 Macro domains.PROSITE-ProRule annotation
Contains 1 PARP catalytic domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2633. Eukaryota.
COG2110. LUCA.
GeneTreeiENSGT00760000119084.
HOGENOMiHOG000026781.
HOVERGENiHBG082106.
InParanoidiQ460N3.
KOiK15261.
OMAiFPMIGTG.
OrthoDBiEOG786H2D.
PhylomeDBiQ460N3.

Family and domain databases

Gene3Di3.90.228.10. 1 hit.
InterProiIPR002589. Macro_dom.
IPR012317. Poly(ADP-ribose)pol_cat_dom.
[Graphical view]
PfamiPF01661. Macro. 2 hits.
PF00644. PARP. 1 hit.
[Graphical view]
SMARTiSM00506. A1pp. 2 hits.
[Graphical view]
PROSITEiPS51154. MACRO. 2 hits.
PS51059. PARP_CATALYTIC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q460N3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPGPLPAA ALSPGAPTPR ELMHGVAGVT SRAGRDREAG SVLPAGNRGA
60 70 80 90 100
RKASRRSSSR SMSRDNKFSK KDCLSIRNVV ASIQTKEGLN LKLISGDVLY
110 120 130 140 150
IWADVIVNSV PMNLQLGGGP LSRAFLQKAG PMLQKELDDR RRETEEKVGN
160 170 180 190 200
IFMTSGCNLD CKAVLHAVAP YWNNGAETSW QIMANIIKKC LTTVEVLSFS
210 220 230 240 250
SITFPMIGTG SLQFPKAVFA KLILSEVFEY SSSTRPITSP LQEVHFLVYT
260 270 280 290 300
NDDEGCQAFL DEFTNWSRIN PNKARIPMAG DTQGVVGTVS KPCFTAYEMK
310 320 330 340 350
IGAITFQVAT GDIATEQVDV IVNSTARTFN RKSGVSRAIL EGAGQAVESE
360 370 380 390 400
CAVLAAQPHR DFIITPGGCL KCKIIIHVPG GKDVRKTVTS VLEECEQRKY
410 420 430 440 450
TSVSLPAIGT GNAGKNPITV ADNIIDAIVD FSSQHSTPSL KTVKVVIFQP
460 470 480 490 500
ELLNIFYDSM KKRDLSASLN FQSTFSMTTC NLPEHWTDMN HQLFCMVQLE
510 520 530 540 550
PGQSEYNTIK DKFTRTCSSY AIEKIERIQN AFLWQSYQVK KRQMDIKNDH
560 570 580 590 600
KNNERLLFHG TDADSVPYVN QHGFNRSCAG KNAVSYGKGT YFAVDASYSA
610 620 630 640 650
KDTYSKPDSN GRKHMYVVRV LTGVFTKGRA GLVTPPPKNP HNPTDLFDSV
660 670
TNNTRSPKLF VVFFDNQAYP EYLITFTA
Length:678
Mass (Da):74,576
Last modified:April 16, 2014 - v2
Checksum:iE299386DA4B2BF8C
GO
Isoform 2 (identifier: Q460N3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-234: Missing.
     235-256: RPITSPLQEVHFLVYTNDDEGC → MLQRIGLIFLHNIVVVSNCFYF

Show »
Length:444
Mass (Da):49,501
Checksum:i1A86C67A336419FC
GO

Sequence cautioni

The sequence AAY64451.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421V → M in AAY64451 (PubMed:16061477).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti337 – 3371R → K.
Corresponds to variant rs6793271 [ dbSNP | Ensembl ].
VAR_027862
Natural varianti521 – 5211A → T.
Corresponds to variant rs34383355 [ dbSNP | Ensembl ].
VAR_056658
Natural varianti628 – 6281G → R.
Corresponds to variant rs12489170 [ dbSNP | Ensembl ].
VAR_027863

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 234234Missing in isoform 2. 2 PublicationsVSP_020971Add
BLAST
Alternative sequencei235 – 25622RPITS…DDEGC → MLQRIGLIFLHNIVVVSNCF YF in isoform 2. 2 PublicationsVSP_020972Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097916 mRNA. Translation: BAC05197.1.
BC101703 mRNA. Translation: AAI01704.1.
BC101701 mRNA. Translation: AAI01702.1.
AC092908 Genomic DNA. No translation available.
DQ063586 mRNA. Translation: AAY64451.1. Different initiation.
CCDSiCCDS3016.1. [Q460N3-2]
CCDS46893.1. [Q460N3-1]
RefSeqiNP_001106995.1. NM_001113523.2. [Q460N3-1]
NP_001295249.1. NM_001308320.1.
NP_689828.1. NM_152615.2. [Q460N3-2]
UniGeneiHs.120250.

Genome annotation databases

EnsembliENST00000310366; ENSP00000308436; ENSG00000173200. [Q460N3-2]
ENST00000464300; ENSP00000417214; ENSG00000173200. [Q460N3-1]
GeneIDi165631.
KEGGihsa:165631.
UCSCiuc003efm.3. human. [Q460N3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097916 mRNA. Translation: BAC05197.1.
BC101703 mRNA. Translation: AAI01704.1.
BC101701 mRNA. Translation: AAI01702.1.
AC092908 Genomic DNA. No translation available.
DQ063586 mRNA. Translation: AAY64451.1. Different initiation.
CCDSiCCDS3016.1. [Q460N3-2]
CCDS46893.1. [Q460N3-1]
RefSeqiNP_001106995.1. NM_001113523.2. [Q460N3-1]
NP_001295249.1. NM_001308320.1.
NP_689828.1. NM_152615.2. [Q460N3-2]
UniGeneiHs.120250.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3BLJX-ray2.20A/B481-678[»]
3GEYX-ray2.20A/B/C/D481-678[»]
3V2BX-ray2.20A295-470[»]
4F0EX-ray2.40A/B/C/D481-678[»]
ProteinModelPortaliQ460N3.
SMRiQ460N3. Positions 51-465, 481-678.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127917. 1 interaction.
STRINGi9606.ENSP00000417214.

Chemistry

ChEMBLiCHEMBL2176778.

PTM databases

iPTMnetiQ460N3.
PhosphoSiteiQ460N3.

Polymorphism and mutation databases

BioMutaiPARP15.
DMDMi116248564.

Proteomic databases

PaxDbiQ460N3.
PRIDEiQ460N3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310366; ENSP00000308436; ENSG00000173200. [Q460N3-2]
ENST00000464300; ENSP00000417214; ENSG00000173200. [Q460N3-1]
GeneIDi165631.
KEGGihsa:165631.
UCSCiuc003efm.3. human. [Q460N3-1]

Organism-specific databases

CTDi165631.
GeneCardsiPARP15.
H-InvDBHIX0200519.
HGNCiHGNC:26876. PARP15.
MIMi612066. gene.
neXtProtiNX_Q460N3.
PharmGKBiPA134905094.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2633. Eukaryota.
COG2110. LUCA.
GeneTreeiENSGT00760000119084.
HOGENOMiHOG000026781.
HOVERGENiHBG082106.
InParanoidiQ460N3.
KOiK15261.
OMAiFPMIGTG.
OrthoDBiEOG786H2D.
PhylomeDBiQ460N3.

Miscellaneous databases

ChiTaRSiPARP15. human.
EvolutionaryTraceiQ460N3.
GenomeRNAii165631.
PROiQ460N3.
SOURCEiSearch...

Gene expression databases

BgeeiQ460N3.
CleanExiHS_PARP15.
ExpressionAtlasiQ460N3. baseline and differential.
GenevisibleiQ460N3. HS.

Family and domain databases

Gene3Di3.90.228.10. 1 hit.
InterProiIPR002589. Macro_dom.
IPR012317. Poly(ADP-ribose)pol_cat_dom.
[Graphical view]
PfamiPF01661. Macro. 2 hits.
PF00644. PARP. 1 hit.
[Graphical view]
SMARTiSM00506. A1pp. 2 hits.
[Graphical view]
PROSITEiPS51154. MACRO. 2 hits.
PS51059. PARP_CATALYTIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Thymus.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Liver.
  4. "B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity."
    Aguiar R.C.T., Takeyama K., He C., Kreinbrink K., Shipp M.A.
    J. Biol. Chem. 280:33756-33765(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-678 (ISOFORM 1), FUNCTION.
  5. "Toward a unified nomenclature for mammalian ADP-ribosyltransferases."
    Hottiger M.O., Hassa P.O., Luscher B., Schuler H., Koch-Nolte F.
    Trends Biochem. Sci. 35:208-219(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.

Entry informationi

Entry nameiPAR15_HUMAN
AccessioniPrimary (citable) accession number: Q460N3
Secondary accession number(s): J3KR47, Q8N1K3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: April 16, 2014
Last modified: June 8, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.