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Protein

Cytoplasmic dynein 2 heavy chain 1

Gene

Dync2h1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. According to PubMed:8666668, it may play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi145 – 1528ATPSequence analysis
Nucleotide bindingi1689 – 16968ATPSequence analysis
Nucleotide bindingi1979 – 19868ATPSequence analysis
Nucleotide bindingi2291 – 22988ATPSequence analysis
Nucleotide bindingi2655 – 26628ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

  • asymmetric protein localization Source: MGI
  • cilium assembly Source: MGI
  • cilium morphogenesis Source: MGI
  • coronary vasculature development Source: MGI
  • determination of left/right symmetry Source: MGI
  • dorsal/ventral pattern formation Source: MGI
  • embryonic limb morphogenesis Source: MGI
  • forebrain development Source: MGI
  • Golgi organization Source: MGI
  • heart development Source: MGI
  • intraciliary retrograde transport Source: MGI
  • neuron differentiation Source: MGI
  • positive regulation of smoothened signaling pathway Source: MGI
  • protein processing Source: MGI
  • spinal cord motor neuron differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Motor protein

Keywords - Biological processi

Cilium biogenesis/degradation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-2132295. MHC class II antigen presentation.
R-MMU-5610787. Hedgehog 'off' state.
R-MMU-5620924. Intraflagellar transport.
R-MMU-6807878. COPI-mediated anterograde transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic dynein 2 heavy chain 1
Alternative name(s):
Cytoplasmic dynein 2 heavy chain
Dynein cytoplasmic heavy chain 2
Dynein heavy chain 11
Short name:
mDHC11
Dynein heavy chain isotype 1B
Gene namesi
Name:Dync2h1
Synonyms:Dhc1b, Dnchc2, Kiaa1997
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:107736. Dync2h1.

Subcellular locationi

GO - Cellular componenti

  • apical part of cell Source: BHF-UCL
  • axoneme Source: BHF-UCL
  • cytoplasmic dynein complex Source: MGI
  • extracellular exosome Source: MGI
  • Golgi apparatus Source: MGI
  • microtubule Source: MGI
  • motile primary cilium Source: BHF-UCL
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Membrane, Microtubule

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi2502 – 25021W → R: Loss of function. 1 Publication
Mutagenesisi3890 – 38901F → S in lln mutant; loss of function. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 43064306Cytoplasmic dynein 2 heavy chain 1PRO_0000318744Add
BLAST

Proteomic databases

MaxQBiQ45VK7.
PaxDbiQ45VK7.
PRIDEiQ45VK7.

PTM databases

PhosphoSiteiQ45VK7.

Expressioni

Tissue specificityi

Detected in brain, lung, spleen and kidney (at protein level). Enriched in the ependymal layer lining the lateral ventricles (at protein level).2 Publications

Developmental stagei

Expressed at E9.5 and E10.5 in the neural tube where it is enriched in rostral part.1 Publication

Gene expression databases

BgeeiQ45VK7.
CleanExiMM_DYNC2H1.
ExpressionAtlasiQ45VK7. baseline and differential.
GenevisibleiQ45VK7. MM.

Interactioni

Subunit structurei

The cytoplasmic dynein complex 2 is probably composed by a heavy chain DYNC2H1 homodimer and a number of DYNC2LI1 light intermediate chains.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046733.

Structurei

3D structure databases

ProteinModelPortaliQ45VK7.
SMRiQ45VK7. Positions 1248-2136, 2910-3535, 3731-3950.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 16501650StemBy similarityAdd
BLAST
Regioni1651 – 1875225AAA 1By similarityAdd
BLAST
Regioni1941 – 2161221AAA 2By similarityAdd
BLAST
Regioni2249 – 2505257AAA 3By similarityAdd
BLAST
Regioni2617 – 2862246AAA 4By similarityAdd
BLAST
Regioni2880 – 3168289StalkBy similarityAdd
BLAST
Regioni3243 – 3472230AAA 5By similarityAdd
BLAST
Regioni3689 – 3904216AAA 6By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili669 – 69628Sequence analysisAdd
BLAST
Coiled coili2896 – 298186Sequence analysisAdd
BLAST
Coiled coili3108 – 319992Sequence analysisAdd
BLAST
Coiled coili3407 – 344135Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3595. Eukaryota.
COG5245. LUCA.
GeneTreeiENSGT00840000129771.
HOVERGENiHBG107832.
InParanoidiQ45VK7.
KOiK10414.
OMAiTSWIICD.
OrthoDBiEOG773XF5.
TreeFamiTF315251.

Family and domain databases

Gene3Di3.40.50.300. 7 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011704. ATPase_dyneun-rel_AAA.
IPR026983. DHC_fam.
IPR024743. Dynein_HC_stalk.
IPR024317. Dynein_heavy_chain_D4_dom.
IPR004273. Dynein_heavy_dom.
IPR013594. Dynein_heavy_dom-1.
IPR013602. Dynein_heavy_dom-2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10676. PTHR10676. 1 hit.
PfamiPF07728. AAA_5. 1 hit.
PF12780. AAA_8. 1 hit.
PF08385. DHC_N1. 1 hit.
PF08393. DHC_N2. 1 hit.
PF03028. Dynein_heavy. 1 hit.
PF12777. MT. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 3 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 5 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q45VK7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGSLGDVRK LFLFTTTQNY FGLRPELWDQ PPLSNCPEVN NFLDDGNQML
60 70 80 90 100
LRVQRSEAGL AFSNTIDFDD AKDKVLVFFK LRPEVITDGN LHNNILVSSM
110 120 130 140 150
LESPINSLYQ AVRQVFAPML LKDQEWSRNF DPKLQNLLSE LEAGLGIVLR
160 170 180 190 200
KSDTNLPKLK LKEDDTRGIL TPSDEFQFWI EQAHRGSKQI SKERASYFKE
210 220 230 240 250
LFETISREFY NLDSLSLLEV VDLVETTRDV VDDVWRQTEH DHYPESRMLH
260 270 280 290 300
LLDVIGGSFG RFVQKKLGSL KLWEDPYYLV KENLKAGISI CEQWVIVCSH
310 320 330 340 350
LTGQVWQRYV PHPWKSGKYF PETLDKLGKR LEEVLAIRTI HEKLLYFLPA
360 370 380 390 400
SEERIVCLSR VFEPFTGVNP VQYNPYTEPL WKAAVSQYEK IIAPAEQKIA
410 420 430 440 450
GKLKNYISEI QDSPQQLLQA FLKYKELVKR PTISKELMLE RETLLARLGD
460 470 480 490 500
SAKDFRLDFE NRCRGIPGDP SGPLSGKNLS EVVNNIVWVR QLELKVDDTI
510 520 530 540 550
KIAEALLSDL SGFRSFHRSA EDLLDQFKLY EQEQFDDWSR EVQSGLSDSR
560 570 580 590 600
SGLCIEANSR IMELDPNDGA LKVHYSDRLV ILLREVRQLS ALGFVIPAKI
610 620 630 640 650
QQVANVAQKF CKQAIILKQV AHFYNSIDQQ MIQSQRPMML QSALAFEQII
660 670 680 690 700
KNSKAGSGGK SQITWDNPKE LEGYIQKLQN AAERLATENR RLRKWHTTFC
710 720 730 740 750
EKVVILMNID LLRQQQRWKD GLQELRTGLA TVAAQGFQAS DMRAWRQHWN
760 770 780 790 800
HQLYKALEHQ YQVGLEALNE NLPEINVDLT YKQGRLQFRP PFEEIRAKYY
810 820 830 840 850
REMKRFIGIP NQFKGVGEAG DESIFSVMID RNASGFLTIY SKAEDLFRRL
860 870 880 890 900
SAVLHQHKEW VVIGQVDMEA LVEKNLSTVH DWEKNFKALK IKGKEVERLP
910 920 930 940 950
SAVKVDCLNI NCSPVKTVID DLIQKLFDLL VLSLKKSIQT HIHEIDTFVT
960 970 980 990 1000
EAMKVLTVIP QSVEEIGDTN VQYSNLQDRR PEILPLFQEA EDKNRLLRTV
1010 1020 1030 1040 1050
AGGGVETVSN LRAKWDKFEL MMESHQLMIK DQIEVMKGNV KSRLQIYYQE
1060 1070 1080 1090 1100
LDKFKARWDQ LKPGDDIIET GQQNTMDQSA KSIKEKKIEF DDLEVIRKKL
1110 1120 1130 1140 1150
VDDCHHFGLE EPNFSLAYSI SKDIESCAQI WALYEEFQQG LQDMAKEDWI
1160 1170 1180 1190 1200
TYRAKIYLFE EFLINWHERL RKIEEHSVMT VKLQSEVDRY KMIIPILKYV
1210 1220 1230 1240 1250
RGEHLSPDHW LDLFRLLGLP RGTSLEKLLF GDLLRVADTI VEKASELKDL
1260 1270 1280 1290 1300
NSRAQGEVTI REALRELDLW GVGAVFSLID YEDSQNHTIK LIKDWKDIVN
1310 1320 1330 1340 1350
QVGDNRCLLQ SLKDSPYYKG FEDKVSIWER KLAQLDEYLQ NLNHIQRKWV
1360 1370 1380 1390 1400
YLEPIFGRGA LPKEQTRFNK VDEDFRSIMM DIRKDSRVTT LTTHAGIRNT
1410 1420 1430 1440 1450
LLTILDQLQR CQKSLNEFLE EKRSAFPRFY FIGDDDLLEI LGQSTNPSVI
1460 1470 1480 1490 1500
QSHLKKLFAG INSVCFDEES KHITAMKSLE GEVVPFKSKV LLSNNVEAWL
1510 1520 1530 1540 1550
NDLALEMKQT LKQLLKECVT AGRSSQGAID PSLFPSQILC LAEQIKFTED
1560 1570 1580 1590 1600
VENAIKDHSL HQIEAQLVAK LERYTSVDTS SEDPGNSESG ILELKLKALI
1610 1620 1630 1640 1650
LDIIHNIDIV KQLNQVQVHT TDDWAWKKQV RFYMKSDHTC YVQMVDSELQ
1660 1670 1680 1690 1700
YTYEYQGNAP KLVYTPLTDK CYLTLTQAMK MGLGGNPYGP AGTGKTESVK
1710 1720 1730 1740 1750
ALGGLLGRQV LVFNCDEGID VKSMGRIFVG LVKCGAWGCF DEFNRLEEAV
1760 1770 1780 1790 1800
LSAVSMQIQT IQDALKNHRT VCELLGKEVE INANSGIFIT MNPAGKGYGG
1810 1820 1830 1840 1850
RQKLPDNLKQ LFRPVAMSRP DNDLIAEVIL YSEGFKDAKE LGRKLVAIFN
1860 1870 1880 1890 1900
LSRELLTPQQ HYDWGLRALK TVLRGSGNLL RQLKKNSTKQ DVNENHIVVQ
1910 1920 1930 1940 1950
ALRLNTMSKF TFADCTRFDA LIKDVFPGID FKEVEYDELS SALKQVFEEA
1960 1970 1980 1990 2000
NYEVIPNQMK KALELYEQLR QRTGVVIVGP SGAGKSTLWR MLRAALCKIG
2010 2020 2030 2040 2050
KVVKQYTMNP KAMPRHQLLG HIDMDTREWS DGVLTNSARQ VVREPQDVSS
2060 2070 2080 2090 2100
WIICDGDIDP EWIESLNSVL DDNRLLTMPS GERIQFGPNV NFVFETHDLS
2110 2120 2130 2140 2150
CASPATISRM GMIFLSDEET DLNSLIKSWL RNQPLEYRSN LENWIGDYFS
2160 2170 2180 2190 2200
KALQWVLKQN DYVVETSLVG TVMNGLSHLH GCKYHDQFII NLIRGLGGNL
2210 2220 2230 2240 2250
NMKSRLEFTK EVFNWARETP PDSHRPMDTY YDCDRGQLAS YMLKKPESLT
2260 2270 2280 2290 2300
ADDFSNGHIL PVIQTPDMQR GLDYFKPWLS SDTKQPFILV GPEGCGKGML
2310 2320 2330 2340 2350
LRYAFSQLRS TEIATIHCSA QTTSRHLLQK LSQTCMVIST NTGRVYRPKD
2360 2370 2380 2390 2400
CERLVLYLKD INLPKLDKWG TSTLVAFLQQ VLTYQGFYDE NLEWVGLENI
2410 2420 2430 2440 2450
QIVASMSAGG RLGRHKLTTR FTSIVRLCAI DYPEREQLQT IYGAYLEAVL
2460 2470 2480 2490 2500
HKNLKNHSIW GSSSKIYLLA GSMVQVYEQV RAKFTVDEYS HYFFTPCILT
2510 2520 2530 2540 2550
QWVLGLFRYD LEGGSSNHPL DYVLEIVAYE ARRLFRDKIV GVKELHLFDN
2560 2570 2580 2590 2600
ILTSVLQGDW GSDILDNMAD SFYVTWGAHH VSGGKTAPGQ PLPPHGKPLG
2610 2620 2630 2640 2650
KLTSADLKDV IKKGLIHYGR DNQNLDILLF QEVLEYMSRI DRVLSFPGGS
2660 2670 2680 2690 2700
LLLAGRSGVG RRTVTSLVSH MHGAVLFSPK ISRGYEPKQF RNDLKHVLQL
2710 2720 2730 2740 2750
AGIEAQQVVL LLEDYQFVHP TFLEMINSLL ASGEVPGLYT LEELEPLLLP
2760 2770 2780 2790 2800
LKDQASQDGF FGPVFNYFTY RIQQNLHIVL IMDSANLNFI VNCESNPALH
2810 2820 2830 2840 2850
KKCQVLWMEG WSDSSMKKIP EMLFSETDGE EKYEKKRKDE KKRNSVDPDF
2860 2870 2880 2890 2900
IKSFLLIHES CKAYGATPSR YMTFLHVYSA ISSSKKKELL KRQSHLQAGV
2910 2920 2930 2940 2950
SKLNEAKALV DELNRKAGEQ SILLRIKQDE ADSALQEITV SMQDASEQKT
2960 2970 2980 2990 3000
ELERLKQRIA EEVVKIEERK SKIDDELKEV QPLVNEAKLA VGNIRPESLS
3010 3020 3030 3040 3050
EIRSLRMPPD VIRDILEGVL RLMGIFDTSW VSMKSFLAKR GVREDIATFD
3060 3070 3080 3090 3100
ARNIPKEIRE SVEELLFKNK ASFDPKNAKR ASTAAAPLAA WVKANVQYSH
3110 3120 3130 3140 3150
VLERIQPLET EQSGLELNLK KTEDRKRKLE DLLNSVGQKV SELKEKFQSR
3160 3170 3180 3190 3200
TSEAAKLEAE VSKAQETIKA AEVLISQLDR EHRRWNAQVA EIAEELATLP
3210 3220 3230 3240 3250
KRAQLAAAFI TYLSAAPEGL RKNCLEEWTK AAGLEKFDLR RFLCTESEQL
3260 3270 3280 3290 3300
IWKSEGLPSD DLSIENALVI LQSRVCPFLI DPSSQATEWL KTHLKDSHLE
3310 3320 3330 3340 3350
VINQQDSNFI TALELAVRFG KTLIIQEMDG VEPVLYPLLR RDLVAQGPRY
3360 3370 3380 3390 3400
VVQIGDKIID YNEDFRLFLS TRNPNPFIPP DAASIVTEVN FTTTRSGLRG
3410 3420 3430 3440 3450
QLLALTIQHE KPDLEEQKTK LLQQEEDKKI QLARLEESLL ETLATSQGNI
3460 3470 3480 3490 3500
LENKDLIESL NQTKASSALI QDSLKESYKL QISLDQERDA YLPLAESASK
3510 3520 3530 3540 3550
MYFIISDLSK INNMYRFSLA SFLRLFQRAL QNKQDSENTE ERIQCLVNSL
3560 3570 3580 3590 3600
KHMVYEYICR CLFKADQLMF ALHFVRGMHP ELFQENEWDT FTGVVVGDML
3610 3620 3630 3640 3650
RKADSQQRIR DQLPSWIDQE RSWAVATLKI SLPSLYQTLC LEDGAFWRTY
3660 3670 3680 3690 3700
YHHSMCEQEF PSILAKKVSL FQQVLVVQAL RPDRLQSAMA LFACKALGLK
3710 3720 3730 3740 3750
ELSPLPLNLK RLYKETLEIE PILIIISPGA DPSQELQELA SAERSSECYH
3760 3770 3780 3790 3800
QVAMGQGQAD LAIQMLKECA RNGDWLCLKN LHLVVSWLPV LEKELNTLQP
3810 3820 3830 3840 3850
KDSFRLWLTA EVHPNFTPIL LQSSLKITYE SPPGLKKNLM RTYESWTPEQ
3860 3870 3880 3890 3900
ISKRDNIHRA HALFSLAWFH AACQERRNYI PQGWTKFYEF SLSDLRAGYH
3910 3920 3930 3940 3950
VIDRLFDGTK DVQWEFVHGL LENSIYGGRV DNYFDLRVLQ SYLKQFFNSS
3960 3970 3980 3990 4000
IIDVLNQRNK KSIFPYSISL PNSCSILDYR AVIEKLPEDD KPSFFGLPAN
4010 4020 4030 4040 4050
IARSSQRMIS SQVISQLRIL GRSVTAGCKF DREIWSNELS PVLNLWKKLN
4060 4070 4080 4090 4100
QNSNLIHQKV SPPNDRQGSP ILSFIILEQF NAIRLVQSVH QSLAALSKVI
4110 4120 4130 4140 4150
RGTTLLSSEV QKLASALLNQ KCPLTWQSRW EGPEDPLQYL RGLVARTLAI
4160 4170 4180 4190 4200
QNWVEKAEKQ VLLADTLDLS ELFHPDTFLN ALRQETARAT GCSVDSLKFV
4210 4220 4230 4240 4250
ASWKGRLQEA KLQIKISGLL LEGCSFDGNR LSENQHDSPS VSSVLPCYMG
4260 4270 4280 4290 4300
WTPQGSYGPY SPDECISLPV YTSAERERVV TNIDVPCGGN QDQWIQCGAA

LFLKNQ
Length:4,306
Mass (Da):492,339
Last modified:September 13, 2005 - v1
Checksum:i0899EEC8224F4B04
GO
Isoform 2 (identifier: Q45VK7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3272-3272: Q → QIIGLKSW

Show »
Length:4,313
Mass (Da):493,137
Checksum:i19AFDB18AC9303CB
GO
Isoform 3 (identifier: Q45VK7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     335-335: L → P
     337-4306: Missing.

Note: No experimental confirmation available.
Show »
Length:336
Mass (Da):38,857
Checksum:i1DFEDCF8F2CEE471
GO

Sequence cautioni

The sequence BAB29399.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC38914.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331L → F in BAC28057 (PubMed:16141072).Curated
Sequence conflicti1254 – 12541A → P in AAS15576 (Ref. 4) Curated
Sequence conflicti1664 – 16641Y → I in CAB06063 (PubMed:9373155).Curated
Sequence conflicti1687 – 16871P → G in CAB06063 (PubMed:9373155).Curated
Sequence conflicti1773 – 17731E → D in CAB06063 (PubMed:9373155).Curated
Sequence conflicti1864 – 18641W → Y in CAB06063 (PubMed:9373155).Curated
Sequence conflicti1866 – 18672LR → IS in CAB06063 (PubMed:9373155).Curated
Sequence conflicti2687 – 26871P → R in AAS15578 (Ref. 4) Curated
Sequence conflicti2699 – 26991Q → K in BAC38914 (PubMed:16141072).Curated
Sequence conflicti2734 – 27341E → K in AAS15578 (Ref. 4) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei335 – 3351L → P in isoform 3. 1 PublicationVSP_031284
Alternative sequencei337 – 43063970Missing in isoform 3. 1 PublicationVSP_031285Add
BLAST
Alternative sequencei3272 – 32721Q → QIIGLKSW in isoform 2. 1 PublicationVSP_031286

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ104402 mRNA. Translation: AAZ41367.1.
AK014500 mRNA. Translation: BAB29399.2. Different initiation.
AK032860 mRNA. Translation: BAC28057.1.
AK045978 mRNA. Translation: BAC32559.1.
AK046538 mRNA. Translation: BAC32776.1.
AK083433 mRNA. Translation: BAC38914.1. Different initiation.
AK084796 mRNA. Translation: BAC39280.1.
CT010499, AC155908 Genomic DNA. Translation: CAX15687.1.
CT010499, AC155908 Genomic DNA. Translation: CAX15688.1.
AY452064 mRNA. Translation: AAS15576.1.
AY452065 mRNA. Translation: AAS15577.1.
AY452066 mRNA. Translation: AAS15578.1.
AY452067 mRNA. Translation: AAS15579.1.
Z83809 mRNA. Translation: CAB06063.1.
AK173324 mRNA. Translation: BAD32602.1.
CCDSiCCDS40528.1. [Q45VK7-1]
RefSeqiNP_084127.2. NM_029851.2. [Q45VK7-1]
XP_006509889.1. XM_006509826.2. [Q45VK7-2]
UniGeneiMm.237596.

Genome annotation databases

EnsembliENSMUST00000048417; ENSMUSP00000046733; ENSMUSG00000047193. [Q45VK7-1]
ENSMUST00000140466; ENSMUSP00000120007; ENSMUSG00000047193. [Q45VK7-1]
ENSMUST00000147193; ENSMUSP00000116679; ENSMUSG00000047193. [Q45VK7-2]
GeneIDi110350.
KEGGimmu:110350.
UCSCiuc009occ.1. mouse. [Q45VK7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ104402 mRNA. Translation: AAZ41367.1.
AK014500 mRNA. Translation: BAB29399.2. Different initiation.
AK032860 mRNA. Translation: BAC28057.1.
AK045978 mRNA. Translation: BAC32559.1.
AK046538 mRNA. Translation: BAC32776.1.
AK083433 mRNA. Translation: BAC38914.1. Different initiation.
AK084796 mRNA. Translation: BAC39280.1.
CT010499, AC155908 Genomic DNA. Translation: CAX15687.1.
CT010499, AC155908 Genomic DNA. Translation: CAX15688.1.
AY452064 mRNA. Translation: AAS15576.1.
AY452065 mRNA. Translation: AAS15577.1.
AY452066 mRNA. Translation: AAS15578.1.
AY452067 mRNA. Translation: AAS15579.1.
Z83809 mRNA. Translation: CAB06063.1.
AK173324 mRNA. Translation: BAD32602.1.
CCDSiCCDS40528.1. [Q45VK7-1]
RefSeqiNP_084127.2. NM_029851.2. [Q45VK7-1]
XP_006509889.1. XM_006509826.2. [Q45VK7-2]
UniGeneiMm.237596.

3D structure databases

ProteinModelPortaliQ45VK7.
SMRiQ45VK7. Positions 1248-2136, 2910-3535, 3731-3950.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046733.

PTM databases

PhosphoSiteiQ45VK7.

Proteomic databases

MaxQBiQ45VK7.
PaxDbiQ45VK7.
PRIDEiQ45VK7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048417; ENSMUSP00000046733; ENSMUSG00000047193. [Q45VK7-1]
ENSMUST00000140466; ENSMUSP00000120007; ENSMUSG00000047193. [Q45VK7-1]
ENSMUST00000147193; ENSMUSP00000116679; ENSMUSG00000047193. [Q45VK7-2]
GeneIDi110350.
KEGGimmu:110350.
UCSCiuc009occ.1. mouse. [Q45VK7-1]

Organism-specific databases

CTDi79659.
MGIiMGI:107736. Dync2h1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3595. Eukaryota.
COG5245. LUCA.
GeneTreeiENSGT00840000129771.
HOVERGENiHBG107832.
InParanoidiQ45VK7.
KOiK10414.
OMAiTSWIICD.
OrthoDBiEOG773XF5.
TreeFamiTF315251.

Enzyme and pathway databases

ReactomeiR-MMU-2132295. MHC class II antigen presentation.
R-MMU-5610787. Hedgehog 'off' state.
R-MMU-5620924. Intraflagellar transport.
R-MMU-6807878. COPI-mediated anterograde transport.

Miscellaneous databases

NextBioi363833.
PROiQ45VK7.
SOURCEiSearch...

Gene expression databases

BgeeiQ45VK7.
CleanExiMM_DYNC2H1.
ExpressionAtlasiQ45VK7. baseline and differential.
GenevisibleiQ45VK7. MM.

Family and domain databases

Gene3Di3.40.50.300. 7 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011704. ATPase_dyneun-rel_AAA.
IPR026983. DHC_fam.
IPR024743. Dynein_HC_stalk.
IPR024317. Dynein_heavy_chain_D4_dom.
IPR004273. Dynein_heavy_dom.
IPR013594. Dynein_heavy_dom-1.
IPR013602. Dynein_heavy_dom-2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10676. PTHR10676. 1 hit.
PfamiPF07728. AAA_5. 1 hit.
PF12780. AAA_8. 1 hit.
PF08385. DHC_N1. 1 hit.
PF08393. DHC_N2. 1 hit.
PF03028. Dynein_heavy. 1 hit.
PF12777. MT. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 3 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 5 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, MUTAGENESIS OF PHE-3890, DEVELOPMENTAL STAGE.
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-889; 1858-2833 AND 3654-4306 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Adrenal gland, Corpora quadrigemina, Heart and Wolffian duct.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "Genomic organization of mouse cytoplasmic dynein heavy chain 2."
    Barbaric I., Bauer T., Wei G.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1850; 1897-2503; 2516-2974 AND 3076-4306 (ISOFORM 2).
    Strain: BALB/cJ.
    Tissue: Thymus.
  5. "Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene."
    Neesen J., Koehler M.R., Kirschner R., Steinlein C., Kreutzberger J., Engel W., Schmid M.
    Gene 200:193-202(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1662-1868 (ISOFORM 1).
    Strain: NMRI.
    Tissue: Testis.
  6. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3081-4306 (ISOFORM 1).
    Tissue: Thymus.
  7. "Mammalian cells express three distinct dynein heavy chains that are localized to different cytoplasmic organelles."
    Vaisberg E.A., Grissom P.M., McIntosh J.R.
    J. Cell Biol. 133:831-842(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  8. "Molecular structure of cytoplasmic dynein 2 and its distribution in neuronal and ciliated cells."
    Mikami A., Tynan S.H., Hama T., Luby-Phelps K., Saito T., Crandall J.E., Besharse J.C., Vallee R.B.
    J. Cell Sci. 115:4801-4808(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  9. "Identification of a novel light intermediate chain (D2LIC) for mammalian cytoplasmic dynein 2."
    Grissom P.M., Vaisberg E.A., McIntosh J.R.
    Mol. Biol. Cell 13:817-829(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  10. "Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli."
    May S.R., Ashique A.M., Karlen M., Wang B., Shen Y., Zarbalis K., Reiter J., Ericson J., Peterson A.S.
    Dev. Biol. 287:378-389(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF TRP-2502.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney, Lung, Spleen and Testis.

Entry informationi

Entry nameiDYHC2_MOUSE
AccessioniPrimary (citable) accession number: Q45VK7
Secondary accession number(s): B8JJF9
, B8JJG0, O08822, Q5VI59, Q5VI60, Q5VI61, Q5VI62, Q69Z42, Q8BJL5, Q8BL87, Q8BMC7, Q8BUI9, Q8BXK5, Q9CRR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 13, 2005
Last modified: May 11, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Mice homozygous for Dync2h1 null alleles die at approximately E12.5 with abnormal brain morphology, frequent heart-looping and occasionally with polysyndactily. Cilia have abnormal morphology.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.