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UniProtKB/Swiss-Prot Q6ZWH5 (NEK10_HUMAN)
Last modified
December 16, 2008.
Version 41.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
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Names and origin
| Protein names | Recommended name: Serine/threonine-protein kinase Nek10 EC=2.7.11.1 Alternative name(s): NimA-related protein kinase 10 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 1172 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | ATP + a protein = ADP + a phosphoprotein. |
| Cofactor | Magnesium By similarity. |
| Sequence similarities | Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. Contains 1 ARM repeat. Contains 1 protein kinase domain. |
Ontologies
Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Coiled coil |
| Ligand | ATP-binding Magnesium Metal-binding Nucleotide-binding |
| Molecular function | Kinase Serine/threonine-protein kinase Transferase |
Gene Ontology (GO) | |
| Biological process | protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: InterPro magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activityInferred from electronic annotation. Source: UniProtKB-KW protein tyrosine kinase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Alternative products
| This entry describes 7 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q6ZWH5-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q6ZWH5-2) The sequence of this isoform differs from the canonical sequence as follows: 672-725: ADFGLAKQKQ...GCILYQMATL → SCLKCAAPLP...IMVPVQPAEP 726-1172: Missing. | ||||||
| Notes: No experimental confirmation available. | ||||||
| Isoform 3 (identifier: Q6ZWH5-3) The sequence of this isoform differs from the canonical sequence as follows: 190-218: YIFQKLAAVKDQREWVTTSGAHKTLVNLL → CKCYCRDTAIFVDLLEKAVWCLQQETRIL 219-1172: Missing. | ||||||
| Notes: No experimental confirmation available. | ||||||
| Isoform 4 (identifier: Q6ZWH5-4) The sequence of this isoform differs from the canonical sequence as follows: 698-712: PEVLKSEPYGEKADV → VQHLYLRSPAPALAT 713-1172: Missing. | ||||||
| Isoform 5 (identifier: Q6ZWH5-5) The sequence of this isoform differs from the canonical sequence as follows: 1-688: Missing. 689-697: VVGTILYSC → MVPVQPAEP | ||||||
| Isoform 6 (identifier: Q6ZWH5-6) The sequence of this isoform differs from the canonical sequence as follows: 1-688: Missing. 689-697: VVGTILYSC → MVPVQPAEP 1004-1013: Missing. | ||||||
| Isoform 7 (identifier: Q6ZWH5-7) The sequence of this isoform differs from the canonical sequence as follows: 1-688: Missing. 689-697: VVGTILYSC → MVPVQPAEP 957-1013: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1172 | 1172 | Serine/threonine-protein kinase Nek10 | PRO_0000259767 | |||||
Regions | |||||||||
| Repeat | 209 – 251 | 43 | ARM | ||||||
| Domain | 519 – 712 | 194 | Protein kinase | ||||||
| Nucleotide binding | 525 – 533 | 9 | ATP By similarity | ||||||
| Coiled coil | 481 – 514 | 34 | Potential | ||||||
Sites | |||||||||
| Active site | 655 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 548 | 1 | ATP By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 688 | 688 | Missing in isoform 5, isoform 6 and isoform 7. | VSP_035688 | |||||
| Alternative sequence | 190 – 218 | 29 | YIFQK…LVNLL → CKCYCRDTAIFVDLLEKAVW CLQQETRIL in isoform 3. | VSP_021534 | |||||
| Alternative sequence | 219 – 1172 | 954 | Missing in isoform 3. | VSP_021535 | |||||
| Alternative sequence | 672 – 725 | 54 | ADFGL…QMATL → SCLKCAAPLPSLSCSCSGHI KRAGSSFAFCYHWELPDASQ EANAIMVPVQPAEP in isoform 2. | VSP_021536 | |||||
| Alternative sequence | 689 – 697 | 9 | VVGTILYSC → MVPVQPAEP in isoform 5, isoform 6 and isoform 7. | VSP_035689 | |||||
| Alternative sequence | 698 – 712 | 15 | PEVLK…EKADV → VQHLYLRSPAPALAT in isoform 4. | VSP_035690 | |||||
| Alternative sequence | 713 – 1172 | 460 | Missing in isoform 4. | VSP_035691 | |||||
| Alternative sequence | 726 – 1172 | 447 | Missing in isoform 2. | VSP_035692 | |||||
| Alternative sequence | 957 – 1013 | 57 | Missing in isoform 7. | VSP_035693 | |||||
| Alternative sequence | 1004 – 1013 | 10 | Missing in isoform 6. | VSP_035694 | |||||
| Natural variant | 50 | 1 | F → L Ref.7 | VAR_040928 | |||||
| Natural variant | 66 | 1 | A → V in an ovarian mucinous carcinoma sample; somatic mutation. Ref.7 | VAR_040929 | |||||
| Natural variant | 67 | 1 | G → S Ref.7 | VAR_040930 | |||||
| Natural variant | 379 | 1 | E → K in a metastatic melanoma sample; somatic mutation. Ref.7 | VAR_040931 | |||||
| Natural variant | 513 | 1 | L → S Ref.7 Ref.6 | VAR_040932 | |||||
| Natural variant | 659 | 1 | N → S Ref.7 | VAR_040933 | |||||
| Natural variant | 701 | 1 | L → V Ref.7 | VAR_040934 | |||||
Experimental info | |||||||||
| Sequence conflict | 239 | 1 | S → G in CAD97860. Ref.6 | ||||||
| Sequence conflict | 762 | 1 | I → F in AAZ20184. Ref.2 | ||||||
| Sequence conflict | 898 | 1 | T → A in AAZ20184. Ref.2 | ||||||
| Sequence conflict | 1155 | 1 | S → P in AAZ20184. Ref.2 | ||||||
Sequences
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References
| [1] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5). Tissue: Testis and Trachea. |
| [2] | Li H., Nong W., Zhou G., Ke R., Shen C., Zhong G., Zheng Z., Liang M., Huang B., Lin L., Yang S. Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7). |
| [3] | "The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. Gibbs R.A.Nature 440:1194-1198(2006) [PubMed: 16641997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6). Tissue: Testis. |
| [6] | The German cDNA consortium Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 75-1172 (ISOFORM 2), VARIANT SER-513. Tissue: Liver. |
| [7] | "Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., |

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