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Q45UF9

- VP2_ROTJ1

UniProt

Q45UF9 - VP2_ROTJ1

Protein

Inner capsid protein VP2

Gene
N/A
Organism
Rotavirus B (isolate Human/China/ADRV-N J19/1997) (RV ADRV-N) (Rotavirus (isolate novel adult diarrhea rotavirus-J19))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Inner capsid protein that self assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices. This capsid constitutes the innermost concentric layer of the viral mature particle. It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP2 is required for the replicase activity of VP1 polymerase. It probably plays a role in the coordination of packaging and genome replication by controlling the initiation of minus-strand synthesis. Binding to the polymerase VP1 presumably activates the autoinhibited VP1-RNA complex which will start the synthesis of the complementary minus-strand By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inner capsid protein VP2
    OrganismiRotavirus B (isolate Human/China/ADRV-N J19/1997) (RV ADRV-N) (Rotavirus (isolate novel adult diarrhea rotavirus-J19))
    Taxonomic identifieri335103 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusunclassified rotaviruses
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000007663: Genome

    Subcellular locationi

    Virion Curated
    Note: Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging By similarity.By similarity

    GO - Cellular componenti

    1. viral inner capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Inner capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 973973Inner capsid protein VP2PRO_0000369835Add
    BLAST

    Interactioni

    Subunit structurei

    Dimer Potential. Interacts with VP1. Interacts with VP3. Interacts with NSP5 By similarity.By similarityCurated

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni449 – 46921HydrophobicAdd
    BLAST

    Sequence similaritiesi

    Belongs to the rotavirus VP2 family.Curated

    Sequencei

    Sequence statusi: Complete.

    Q45UF9-1 [UniParc]FASTAAdd to Basket

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    MEVIEKLETI RETLNDTKDK KDFQKIHDEL VQYLDGIDPL TIDDDKWNEI    50
    LKLFKIIIVK LKNSTIKTTS LENELTQHEK KRTVKEVEKV EEDMKVDVAN 100
    DNSKPTLMDK VLQVSSQPNN PYSADVLQIR TILSKTLFVD TDSEAYSLYV 150
    PESQKLDVSP ITIELTTIEK YQPKVNILKQ AVIVPSQNPL LADTYGAPEI 200
    LFSTDFFDDI TSNSSEGLQL YFFDKAYKLK KELPNLPFLS SLDKDVNPLN 250
    PLNSVCKSFG QEKYYDMVMD RTDRGLDARR AAMQFDNVIV DAQNRTVQFN 300
    VRMHPFDLQL LRISQQFAEP MQDLAPVVRE YMMLGADGYV LTQKTRLDRD 350
    QQLIANRRSV VFDRMCELSG PLYRSRIVHS MRMMSKLWRT NVFRTSLEDE 400
    ITKIYAAAEV SMVSIDATTS ALSTINIASA EQTLNALLNM SFFRCELDLI 450
    GSQSSFGAAM SAMIALMILP TDQENMDDEV FDVLCNLVYN ELIAWAADRP 500
    VFVRRAGATN AFRQFVNAGL NRDITNYMRF VLLRRPWLPL YNSRDVRRNA 550
    HVLVPNVDLA NINDQVYVAI NSFLNGIIEA SRRNPNPNKT ISANSFRKLM 600
    KNMRDICVNR LMPVIRLIRY NVERIGMILH MLPYSADIFD INRNLRDERL 650
    RIKIPMSGFL SLVMGITKAP DAFDWSQVLN FADDVRKMDY AEAISIEDSA 700
    SVAIMRNDAN RATSKKEIFI SEVKPPTPTV ASIQKIPSAT LTAMFSDRQL 750
    INLIRDTHSF RVIREIAVAL QAAFDNSPTS QHGVGKGAVL HPVPQNFGRS 800
    SQFVRRDNIL LQRPAGIQQF TIEDLKQGRY FQGLMAQIRA RQPIIVNGPI 850
    PLRISDAAEI EQVTLAFLTM NSPYDAYIDP RDLKQQKLLT DREVDLFIDQ 900
    NPARPNDEFD NVMARTSVFI IDAPRAIVPI NPQRLNFPYH DIMVTDSVTK 950
    FIEFTVALTP DLQLFNGLLV FEQ 973
    Length:973
    Mass (Da):111,047
    Last modified:September 13, 2005 - v1
    Checksum:i244A74E56A9F0D44
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ113898 Genomic RNA. Translation: AAZ03486.1.
    RefSeqiYP_392491.1. NC_007549.1.

    Genome annotation databases

    GeneIDi5076651.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ113898 Genomic RNA. Translation: AAZ03486.1 .
    RefSeqi YP_392491.1. NC_007549.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5076651.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of a novel adult diarrhoea rotavirus strain J19 isolated in China and its significance for the evolution and origin of group B rotaviruses."
      Jiang S., Ji S., Tang Q., Cui X., Yang H., Kan B., Gao S.
      J. Gen. Virol. 89:2622-2629(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiVP2_ROTJ1
    AccessioniPrimary (citable) accession number: Q45UF9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3