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Protein

Non-structural protein 1

Gene
N/A
Organism
Rotavirus B (isolate Human/China/ADRV-N J19/1997) (RV ADRV-N) (Rotavirus (isolate novel adult diarrhea rotavirus-J19))
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei326 – 3272Cleavage; by autolysisSequence Analysis

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein 1
Short name:
NSP1
OrganismiRotavirus B (isolate Human/China/ADRV-N J19/1997) (RV ADRV-N) (Rotavirus (isolate novel adult diarrhea rotavirus-J19))
Taxonomic identifieri335103 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusunclassified rotaviruses
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000007663 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 395395Non-structural protein 1PRO_0000369859Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ45UF6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini328 – 39568DRBMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DRBM (double-stranded RNA-binding) domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
InterProiIPR014720. dsRNA-bd_dom.
[Graphical view]
PfamiPF00035. dsrm. 1 hit.
[Graphical view]
SMARTiSM00358. DSRM. 1 hit.
[Graphical view]
PROSITEiPS50137. DS_RBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q45UF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSIQRAAQI NRQFDYMSIK ELWMAKFPLH KPGDCLDMFK NGDYTGPTMG
60 70 80 90 100
CIQKTKASKK NTIFHIKSDF NSTEYDEPPI SGFKMFTQHC CQRIDEHFCG
110 120 130 140 150
ALHPVISNIE FEHNQLKTRP QVASELNLFI PCGIKNLKIE SGEKSTWIVG
160 170 180 190 200
TKFRKCMCLK PVIVAATIIG TPINKNLITF CSSDYIQVIV NRNREGSCGI
210 220 230 240 250
CMGNVSTYEA CGNWTNETWG EEFSLDLKLC YKCTPVAFIF SLMMSTGHKP
260 270 280 290 300
YVSKKQFEEN RRKWERVLNY KICKENLDSH LACANHENVY KSIKKYEFFD
310 320 330 340 350
SVWVYHLANS SWVRDLTREC IESNPGPNYI QLLNEHSQRY GFVQPTYEII
360 370 380 390
AVVSDGHHSY QCTCYYKDMK TQSTGPSKKN AKHQAAEQMF RHQCF
Length:395
Mass (Da):45,649
Last modified:September 13, 2005 - v1
Checksum:i19D9915601794AB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY632079 Genomic RNA. Translation: AAU88188.1.
DQ113901 Genomic RNA. Translation: AAZ03489.1.
RefSeqiYP_392494.1. NC_007552.1.

Genome annotation databases

GeneIDi5076654.
KEGGivg:5076654.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY632079 Genomic RNA. Translation: AAU88188.1.
DQ113901 Genomic RNA. Translation: AAZ03489.1.
RefSeqiYP_392494.1. NC_007552.1.

3D structure databases

ProteinModelPortaliQ45UF6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5076654.
KEGGivg:5076654.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
InterProiIPR014720. dsRNA-bd_dom.
[Graphical view]
PfamiPF00035. dsrm. 1 hit.
[Graphical view]
SMARTiSM00358. DSRM. 1 hit.
[Graphical view]
PROSITEiPS50137. DS_RBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and sequence analysis of dsRNA segments 5, 6 and 7 of a novel non-group A, B, C adult rotavirus that caused an outbreak of gastroenteritis in China."
    Yang H., Makeyev E.V., Kang Z., Ji S., Bamford D.H., van Dijk A.A.
    Virus Res. 106:15-26(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Molecular characterization of a novel adult diarrhoea rotavirus strain J19 isolated in China and its significance for the evolution and origin of group B rotaviruses."
    Jiang S., Ji S., Tang Q., Cui X., Yang H., Kan B., Gao S.
    J. Gen. Virol. 89:2622-2629(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiNSP1N_ROTJ1
AccessioniPrimary (citable) accession number: Q45UF6
Secondary accession number(s): Q5Y9B1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 13, 2005
Last modified: April 1, 2015
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.