ID   VP6_ROTJ1               Reviewed;         396 AA.
AC   Q45UF5; Q5Y9B0;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   08-NOV-2023, entry version 47.
DE   RecName: Full=Intermediate capsid protein VP6 {ECO:0000255|HAMAP-Rule:MF_04126};
OS   Rotavirus X (strain RVX/Human/China/NADRV-J19/1997/GXP[X]) (RV ADRV-N)
OS   (Rotavirus (isolate novel adult diarrhea rotavirus-J19)).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Sedoreoviridae; Rotavirus; Rotavirus H.
OX   NCBI_TaxID=335103;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=15522443; DOI=10.1016/j.virusres.2004.05.011;
RA   Yang H., Makeyev E.V., Kang Z., Ji S., Bamford D.H., van Dijk A.A.;
RT   "Cloning and sequence analysis of dsRNA segments 5, 6 and 7 of a novel non-
RT   group A, B, C adult rotavirus that caused an outbreak of gastroenteritis in
RT   China.";
RL   Virus Res. 106:15-26(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=18796732; DOI=10.1099/vir.0.2008/001933-0;
RA   Jiang S., Ji S., Tang Q., Cui X., Yang H., Kan B., Gao S.;
RT   "Molecular characterization of a novel adult diarrhoea rotavirus strain J19
RT   isolated in China and its significance for the evolution and origin of
RT   group B rotaviruses.";
RL   J. Gen. Virol. 89:2622-2629(2008).
CC   -!- FUNCTION: Intermediate capsid protein that self assembles to form an
CC       icosahedral capsid with a T=13 symmetry, which consists of 230 trimers
CC       of VP6, with channels at each of its five-fold vertices. This capsid
CC       constitutes the middle concentric layer of the viral mature particle.
CC       The innermost VP2 capsid and the intermediate VP6 capsid remain intact
CC       following cell entry to protect the dsRNA from degradation and to
CC       prevent unfavorable antiviral responses in the host cell during all the
CC       replication cycle of the virus. Nascent transcripts are transcribed
CC       within the structural confines of this double-layered particle (DLP)
CC       and are extruded through the channels at the five-fold axes. VP6 is
CC       required for the transcription activity of the DLP. {ECO:0000255|HAMAP-
CC       Rule:MF_04126}.
CC   -!- SUBUNIT: Homotrimer. Interacts with the inner capsid protein VP2.
CC       Interacts with the outer capsid glycoprotein VP7. {ECO:0000255|HAMAP-
CC       Rule:MF_04126}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04126}.
CC       Note=Component of the intermediate capsid. Also found in spherical
CC       cytoplasmic structures, called virus factories, that appear early after
CC       infection and are the site of viral replication and packaging.
CC       {ECO:0000255|HAMAP-Rule:MF_04126}.
CC   -!- SIMILARITY: Belongs to the rotavirus VP6 family. {ECO:0000255|HAMAP-
CC       Rule:MF_04126}.
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DR   EMBL; AY632080; AAU88189.1; -; Genomic_RNA.
DR   EMBL; DQ113902; AAZ03490.1; -; Genomic_RNA.
DR   RefSeq; YP_392495.1; NC_007553.1.
DR   GeneID; 5076655; -.
DR   KEGG; vg:5076655; -.
DR   OrthoDB; 13985at10239; -.
DR   Proteomes; UP000007663; Genome.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-UniRule.
DR   GO; GO:0039626; C:viral intermediate capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0046789; F:host cell surface receptor binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005198; F:structural molecule activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04126; Rota_VP6; 1.
DR   InterPro; IPR001385; Rotavirus_A/C_VP6.
PE   3: Inferred from homology;
KW   Capsid protein; Intermediate capsid protein; Reference proteome; Virion.
FT   CHAIN           1..396
FT                   /note="Intermediate capsid protein VP6"
FT                   /id="PRO_0000369861"
SQ   SEQUENCE   396 AA;  42922 MW;  551752104A219250 CRC64;
     MDLIETINAV VELQHRVRNL SPNTNIYQDG QTTINDYNAI ASRCNGKVYN LRDQIAQLSP
     FQVHMPVIPI STILSTDDHE TMSAGIESLF DVLAAAIRTE GSRQNRAVVT KSIEPEVLKA
     VLDIGIRSQF SENPYANMLQ VDTAKMEQQL EPIDDPLASQ RINMLAAGGA TNNTGGGYHA
     LVGRATGKTG IITIIQGRPG AVTFNLNMKV PCSGVLSLTL LPAPGVIQLS LGNQPPNNIP
     VHAECVDVST VFTEGDIVIR FELAGRVVGN ANKLGTLNFP LCDRISITIE PWNANKQNNA
     NANFNNWPAG TAQRQPTISL FVNIINASSL IDYETHSKYL AGATYLMGTT FSEDSFIASP
     PNVVWTMSSL LSGAPPQYIH WTRKIACMIA AFSCKI
//