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Protein

Intermediate capsid protein VP6

Gene
N/A
Organism
Rotavirus B (isolate Human/China/ADRV-N J19/1997) (RV ADRV-N) (Rotavirus (isolate novel adult diarrhea rotavirus-J19))
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Intermediate capsid protein VP6
OrganismiRotavirus B (isolate Human/China/ADRV-N J19/1997) (RV ADRV-N) (Rotavirus (isolate novel adult diarrhea rotavirus-J19))
Taxonomic identifieri335103 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusunclassified rotaviruses
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000007663: Genome

Subcellular locationi

Virion By similarity
Note: Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging (Potential).Curated

GO - Cellular componenti

  1. viral intermediate capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Intermediate capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Intermediate capsid protein VP6PRO_0000369861Add
BLAST

Interactioni

Subunit structurei

Homotrimer. Interacts with VP2.By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the rotavirus VP6 family.Curated

Family and domain databases

InterProiIPR020245. Rotavirus_B_VP6.
[Graphical view]
ProDomiPD042229. Rotavirus_B_VP6. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q45UF5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLIETINAV VELQHRVRNL SPNTNIYQDG QTTINDYNAI ASRCNGKVYN
60 70 80 90 100
LRDQIAQLSP FQVHMPVIPI STILSTDDHE TMSAGIESLF DVLAAAIRTE
110 120 130 140 150
GSRQNRAVVT KSIEPEVLKA VLDIGIRSQF SENPYANMLQ VDTAKMEQQL
160 170 180 190 200
EPIDDPLASQ RINMLAAGGA TNNTGGGYHA LVGRATGKTG IITIIQGRPG
210 220 230 240 250
AVTFNLNMKV PCSGVLSLTL LPAPGVIQLS LGNQPPNNIP VHAECVDVST
260 270 280 290 300
VFTEGDIVIR FELAGRVVGN ANKLGTLNFP LCDRISITIE PWNANKQNNA
310 320 330 340 350
NANFNNWPAG TAQRQPTISL FVNIINASSL IDYETHSKYL AGATYLMGTT
360 370 380 390
FSEDSFIASP PNVVWTMSSL LSGAPPQYIH WTRKIACMIA AFSCKI
Length:396
Mass (Da):42,922
Last modified:September 13, 2005 - v1
Checksum:i551752104A219250
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY632080 Genomic RNA. Translation: AAU88189.1.
DQ113902 Genomic RNA. Translation: AAZ03490.1.
RefSeqiYP_392495.1. NC_007553.1.

Genome annotation databases

GeneIDi5076655.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY632080 Genomic RNA. Translation: AAU88189.1.
DQ113902 Genomic RNA. Translation: AAZ03490.1.
RefSeqiYP_392495.1. NC_007553.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5076655.

Family and domain databases

InterProiIPR020245. Rotavirus_B_VP6.
[Graphical view]
ProDomiPD042229. Rotavirus_B_VP6. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and sequence analysis of dsRNA segments 5, 6 and 7 of a novel non-group A, B, C adult rotavirus that caused an outbreak of gastroenteritis in China."
    Yang H., Makeyev E.V., Kang Z., Ji S., Bamford D.H., van Dijk A.A.
    Virus Res. 106:15-26(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Molecular characterization of a novel adult diarrhoea rotavirus strain J19 isolated in China and its significance for the evolution and origin of group B rotaviruses."
    Jiang S., Ji S., Tang Q., Cui X., Yang H., Kan B., Gao S.
    J. Gen. Virol. 89:2622-2629(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiVP6_ROTJ1
AccessioniPrimary (citable) accession number: Q45UF5
Secondary accession number(s): Q5Y9B0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 13, 2005
Last modified: January 7, 2015
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.