Q45UF4 (NSP2_ROTJ1) Reviewed, UniProtKB/Swiss-Prot
Last modified September 18, 2013. Version 25. History...
Names and origin
|Protein names||Recommended name:|
Non-structural protein 2
|Organism||Rotavirus B (isolate Human/China/ADRV-N J19/1997) (RV ADRV-N) (Rotavirus (isolate novel adult diarrhea rotavirus-J19)) [Reference proteome]|
|Taxonomic identifier||335103 [NCBI]|
|Taxonomic lineage||Viruses › dsRNA viruses › Reoviridae › Sedoreovirinae › Rotavirus › unclassified rotaviruses ›|
|Virus host||Homo sapiens (Human) [TaxID: 9606]|
|Sequence length||297 AA.|
|Protein existence||Inferred from homology|
General annotation (Comments)
Involved in genome replication and packaging. Plays a crucial role, together with NSP5, in the formation of virus factories (viroplasms) which are large inclusions in the cytoplasm where replication intermediates are assembled and RNA replication takes place. Displays ssRNA binding, NTPase, RNA triphosphatase (RTPase) and ATP-independent helix-unwinding activity activities. The unwiding activity may prepare and organize plus-strand RNAs for packaging and replication by removing interfering secondary structures. Unlike typical helicases, NSP2 requires neither a divalent cation nor a nucleotide energy source for helix destabilization. The RTPase activity may account for the absence of the 5'-terminal gamma-phosphate on the minus-strands of dsRNA genome segments By similarity.
Homooctamer By similarity. Interacts with NSP5; this interaction leads to formation of virus factories By similarity.
Host cytoplasm Potential. Note: Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging By similarity.
Belongs to the rotavirus NSP2 family.
|Cellular component||Host cytoplasm|
|Technical term||Complete proteome|
|Gene Ontology (GO)|
|Cellular_component||host cell cytoplasm|
Inferred from electronic annotation. Source: UniProtKB-SubCell
Inferred from electronic annotation. Source: UniProtKB-KWhydrolase activity
Inferred from electronic annotation. Source: UniProtKB-KWnucleotide binding
Inferred from electronic annotation. Source: UniProtKB-KW
|Complete GO annotation...|
Sequence annotation (Features)
|||"Molecular characterization of a novel adult diarrhoea rotavirus strain J19 isolated in China and its significance for the evolution and origin of group B rotaviruses."|
Jiang S., Ji S., Tang Q., Cui X., Yang H., Kan B., Gao S.
J. Gen. Virol. 89:2622-2629(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
|DQ113903 Genomic RNA. Translation: AAZ03491.1.|
|RefSeq||YP_392496.1. NC_007554.1. |
3D structure databases
Protocols and materials databases
Genome annotation databases
Family and domain databases
|Accession||Primary (citable) accession number: Q45UF4|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Viral Protein Annotation Program|
Index of protein domains and families