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Q45UF2 (VP7_ROTJ1) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Outer capsid protein involved in attachment and possibly entry into the host epithelial cell. It is subsequently lost, together with VP4, following virus entry into the host cell. The outer layer contains 780 copies of VP7, grouped as 260 trimers. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors By similarity.

Subunit structure

Homotrimer; in the presence of calcium By similarity. Acquisition of the capsid outer layer requires a high calcium concentration inside the endoplasmic reticulum. Following cell entry, the low calcium concentration in the cytoplasm is probably responsible for the solubilization of the outer layer By similarity.

Subcellular location

Virion Potential. Host rough endoplasmic reticulum membrane; Single-pass membrane protein; Lumenal side Potential. Note: Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles By similarity.

Sequence similarities

Belongs to the rotavirus VP7 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 258258Outer capsid glycoprotein VP7
PRO_0000369863

Regions

Transmembrane1 – ?1313Helical; Potential

Amino acid modifications

Glycosylation421N-linked (GlcNAc...); by host Potential

Sequences

Sequence LengthMass (Da)Tools
Q45UF2 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 55DFEC621B61DBB8

FASTA25829,265
        10         20         30         40         50         60 
MLLFIILSVG VDAISYIQND RSNDLCIVYE MTSFGTSFNN ANDSLVKLHK HMGLKYEVCK 

        70         80         90        100        110        120 
IESNANALTQ MQKCNCIYDD TPQIVVFTNF KKSSLKTLIG TENKCELLPQ TTIYTPTVDI 

       130        140        150        160        170        180 
ESEYFIYGND VKICYLDKNL LGIGCDATDT TSWLDLDAGL PTNHALDIPE ITSDGFKLFA 

       190        200        210        220        230        240 
KYSDSFLCQR LMDEPKKQIQ FYAEVDNVPS NDVIESSRSW ASVWKVVKTV LHFTYHILDL 

       250 
FYGNRRATAR MIEHSPLG 

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References

[1]"Molecular characterization of a novel adult diarrhoea rotavirus strain J19 isolated in China and its significance for the evolution and origin of group B rotaviruses."
Jiang S., Ji S., Tang Q., Cui X., Yang H., Kan B., Gao S.
J. Gen. Virol. 89:2622-2629(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ113905 Genomic RNA. Translation: AAZ03493.1.
RefSeqYP_392498.1. NC_007556.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5076658.

Family and domain databases

InterProIPR008818. Rotavirus_VP7.
[Graphical view]
PfamPF05868. Rotavirus_VP7. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameVP7_ROTJ1
AccessionPrimary (citable) accession number: Q45UF2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 13, 2005
Last modified: February 19, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families