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Protein

Non-structural protein 5

Gene
N/A
Organism
Rotavirus X (strain RVX/Human/China/NADRV-J19/1997/GXP[X]) (RV ADRV-N) (Rotavirus (isolate novel adult diarrhea rotavirus-J19))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays an essential role in the viral genome replication. Participates, together with NSP2, in the formation of viral factories (viroplasms) which are large inclusions in the host cytoplasm where replication intermediates are assembled and viral RNA replication takes place. Orchestrates the recruitment of viroplasmic proteins such as capsid proteins to these factories.UniRule annotation

Keywordsi

Molecular functionRNA-binding
LigandNucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein 5UniRule annotation
Short name:
NSP5UniRule annotation
Alternative name(s):
NS26UniRule annotation
OrganismiRotavirus X (strain RVX/Human/China/NADRV-J19/1997/GXP[X]) (RV ADRV-N) (Rotavirus (isolate novel adult diarrhea rotavirus-J19))
Taxonomic identifieri335103 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000007663 Componenti: Genome

Subcellular locationi

  • Host cytoplasm UniRule annotation
  • Note: Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003698681 – 176Non-structural protein 5Add BLAST176

Post-translational modificationi

O-glycosylated.UniRule annotation

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ45UF0

Interactioni

Subunit structurei

Homodimer. Interacts with VP1. Interacts with VP2. Interacts with NSP2; this interaction leads to up-regulation of NSP5 hyperphosphorylation and formation of virus factories. Interacts with NSP6.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the rotavirus NSP5 family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG090002GY

Family and domain databases

HAMAPiMF_04092 ROTA_NSP5, 1 hit
InterProiView protein in InterPro
IPR020244 Rotavirus_B_NSP5
PfamiView protein in Pfam
PF17580 GBR_NSP5, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD035122 Rotavirus_B_NSP5, 1 hit

Sequencei

Sequence statusi: Complete.

Q45UF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEVPRFELR SKRKIGKKQK VDIFGDKDDE SMLQIDCETD SLISESVSST
60 70 80 90 100
HSYEDYSKAY KELTLETPAD VNDSASTIVD SVCEESWYDK TIKDEQTKED
110 120 130 140 150
KKTDKKLKRI EKVKENNQND SMSLQIAQLS LRIQRIESET KLKTLDSAYN
160 170
TIITQADNLT TPQKKSLISA ILATMR
Length:176
Mass (Da):20,138
Last modified:September 13, 2005 - v1
Checksum:iCE5DBF0DD89BCE74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ113907 Genomic RNA Translation: AAZ03495.1
RefSeqiYP_392500.1, NC_007558.1

Genome annotation databases

GeneIDi5076660
KEGGivg:5076660

Similar proteinsi

Entry informationi

Entry nameiNSP5_ROTJ1
AccessioniPrimary (citable) accession number: Q45UF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 13, 2005
Last modified: May 23, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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