Q45UF0 (NSP5_ROTJ1) Reviewed, UniProtKB/Swiss-Prot
Last modified September 18, 2013. Version 24. History...
Names and origin
|Protein names||Recommended name:|
Non-structural protein 5
|Organism||Rotavirus B (isolate Human/China/ADRV-N J19/1997) (RV ADRV-N) (Rotavirus (isolate novel adult diarrhea rotavirus-J19)) [Reference proteome]|
|Taxonomic identifier||335103 [NCBI]|
|Taxonomic lineage||Viruses › dsRNA viruses › Reoviridae › Sedoreovirinae › Rotavirus › unclassified rotaviruses ›|
|Virus host||Homo sapiens (Human) [TaxID: 9606]|
|Sequence length||176 AA.|
|Protein existence||Inferred from homology|
General annotation (Comments)
Involved in genome replication. Plays a crucial role, together with NSP2, in the formation of virus factories (viroplasms) which are large inclusions in the cytoplasm where core-like replication intermediates are assembled and RNA replication takes place By similarity.
Homodimer. Interacts with VP1. Interacts with VP2. Interacts with NSP2; this interaction leads to formation of virus factories By similarity.
Host cytoplasm. Note: Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging By similarity.
Belongs to the rotavirus B NSP5 family.
Sequence annotation (Features)
|||"Molecular characterization of a novel adult diarrhoea rotavirus strain J19 isolated in China and its significance for the evolution and origin of group B rotaviruses."|
Jiang S., Ji S., Tang Q., Cui X., Yang H., Kan B., Gao S.
J. Gen. Virol. 89:2622-2629(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
|DQ113907 Genomic RNA. Translation: AAZ03495.1.|
|RefSeq||YP_392500.1. NC_007558.1. |
3D structure databases
Protocols and materials databases
Genome annotation databases
Family and domain databases
|InterPro||IPR020244. Rotavirus_B_NSP5. |
|ProDom||PD035122. Rotavirus_B_NSP5. 1 hit. |
[Graphical view] [Entries sharing at least one domain]
|Accession||Primary (citable) accession number: Q45UF0|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Viral Protein Annotation Program|
Index of protein domains and families