Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q45UF0

- NSP5_ROTJ1

UniProt

Q45UF0 - NSP5_ROTJ1

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Non-structural protein 5

Gene
N/A
Organism
Rotavirus B (isolate Human/China/ADRV-N J19/1997) (RV ADRV-N) (Rotavirus (isolate novel adult diarrhea rotavirus-J19))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Involved in genome replication. Plays a crucial role, together with NSP2, in the formation of virus factories (viroplasms) which are large inclusions in the cytoplasm where core-like replication intermediates are assembled and RNA replication takes place (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein 5
Short name:
NSP5
OrganismiRotavirus B (isolate Human/China/ADRV-N J19/1997) (RV ADRV-N) (Rotavirus (isolate novel adult diarrhea rotavirus-J19))
Taxonomic identifieri335103 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusunclassified rotaviruses
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000007663: Genome

Subcellular locationi

Host cytoplasm
Note: Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.By similarity

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 176176Non-structural protein 5PRO_0000369868Add
BLAST

Interactioni

Subunit structurei

Homodimer. Interacts with VP1. Interacts with VP2. Interacts with NSP2; this interaction leads to formation of virus factories (By similarity).By similarity

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili105 – 13935Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the rotavirus B NSP5 family.Curated

Keywords - Domaini

Coiled coil

Family and domain databases

InterProiIPR020244. Rotavirus_B_NSP5.
[Graphical view]
ProDomiPD035122. Rotavirus_B_NSP5. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q45UF0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEVPRFELR SKRKIGKKQK VDIFGDKDDE SMLQIDCETD SLISESVSST
60 70 80 90 100
HSYEDYSKAY KELTLETPAD VNDSASTIVD SVCEESWYDK TIKDEQTKED
110 120 130 140 150
KKTDKKLKRI EKVKENNQND SMSLQIAQLS LRIQRIESET KLKTLDSAYN
160 170
TIITQADNLT TPQKKSLISA ILATMR
Length:176
Mass (Da):20,138
Last modified:September 13, 2005 - v1
Checksum:iCE5DBF0DD89BCE74
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ113907 Genomic RNA. Translation: AAZ03495.1.
RefSeqiYP_392500.1. NC_007558.1.

Genome annotation databases

GeneIDi5076660.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ113907 Genomic RNA. Translation: AAZ03495.1 .
RefSeqi YP_392500.1. NC_007558.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5076660.

Family and domain databases

InterProi IPR020244. Rotavirus_B_NSP5.
[Graphical view ]
ProDomi PD035122. Rotavirus_B_NSP5. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization of a novel adult diarrhoea rotavirus strain J19 isolated in China and its significance for the evolution and origin of group B rotaviruses."
    Jiang S., Ji S., Tang Q., Cui X., Yang H., Kan B., Gao S.
    J. Gen. Virol. 89:2622-2629(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiNSP5_ROTJ1
AccessioniPrimary (citable) accession number: Q45UF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 13, 2005
Last modified: October 29, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3