Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q45UF0

- NSP5_ROTJ1

UniProt

Q45UF0 - NSP5_ROTJ1

Protein

Non-structural protein 5

Gene
N/A
Organism
Rotavirus B (isolate Human/China/ADRV-N J19/1997) (RV ADRV-N) (Rotavirus (isolate novel adult diarrhea rotavirus-J19))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in genome replication. Plays a crucial role, together with NSP2, in the formation of virus factories (viroplasms) which are large inclusions in the cytoplasm where core-like replication intermediates are assembled and RNA replication takes place By similarity.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Non-structural protein 5
    Short name:
    NSP5
    OrganismiRotavirus B (isolate Human/China/ADRV-N J19/1997) (RV ADRV-N) (Rotavirus (isolate novel adult diarrhea rotavirus-J19))
    Taxonomic identifieri335103 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusunclassified rotaviruses
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000007663: Genome

    Subcellular locationi

    Host cytoplasm
    Note: Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.By similarity

    GO - Cellular componenti

    1. host cell cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 176176Non-structural protein 5PRO_0000369868Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer. Interacts with VP1. Interacts with VP2. Interacts with NSP2; this interaction leads to formation of virus factories By similarity.By similarity

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili105 – 13935Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the rotavirus B NSP5 family.Curated

    Keywords - Domaini

    Coiled coil

    Family and domain databases

    InterProiIPR020244. Rotavirus_B_NSP5.
    [Graphical view]
    ProDomiPD035122. Rotavirus_B_NSP5. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Q45UF0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEVPRFELR SKRKIGKKQK VDIFGDKDDE SMLQIDCETD SLISESVSST    50
    HSYEDYSKAY KELTLETPAD VNDSASTIVD SVCEESWYDK TIKDEQTKED 100
    KKTDKKLKRI EKVKENNQND SMSLQIAQLS LRIQRIESET KLKTLDSAYN 150
    TIITQADNLT TPQKKSLISA ILATMR 176
    Length:176
    Mass (Da):20,138
    Last modified:September 13, 2005 - v1
    Checksum:iCE5DBF0DD89BCE74
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ113907 Genomic RNA. Translation: AAZ03495.1.
    RefSeqiYP_392500.1. NC_007558.1.

    Genome annotation databases

    GeneIDi5076660.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ113907 Genomic RNA. Translation: AAZ03495.1 .
    RefSeqi YP_392500.1. NC_007558.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5076660.

    Family and domain databases

    InterProi IPR020244. Rotavirus_B_NSP5.
    [Graphical view ]
    ProDomi PD035122. Rotavirus_B_NSP5. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of a novel adult diarrhoea rotavirus strain J19 isolated in China and its significance for the evolution and origin of group B rotaviruses."
      Jiang S., Ji S., Tang Q., Cui X., Yang H., Kan B., Gao S.
      J. Gen. Virol. 89:2622-2629(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiNSP5_ROTJ1
    AccessioniPrimary (citable) accession number: Q45UF0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3