Phospholipase C beta 2 - Rattus norvegicus (Rat)

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Unreviewed, UniProtKB/TrEMBL Q45QJ6 (Q45QJ6_RAT)

Last modified February 9, 2010. Version 42. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

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Names and origin

Protein names

Submitted name:
Phospholipase C beta 2 EMBL AAZ23845.1

Gene names

Name:

Plcb2 EMBL AAZ23845.1

Organism

Rattus norvegicus (Rat) EMBL AAZ23845.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length	1090 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Sequence similarities

Contains 1 C2 domain.

Contains 1 PI-PLC X-box domain.

Contains 1 PI-PLC Y-box domain.

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Ontologies

Keywords
Molecular function	Transducer Spearmint SPM001192
Gene Ontology (GO)
Biological process	detection of chemical stimulus involved in sensory perception of bitter taste Inferred from mutant phenotype. Source: RGD intracellular signaling cascade Inferred from electronic annotation. Source: InterPro lipid catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi apparatus Inferred from direct assay. Source: RGD
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro phosphoinositide phospholipase C activity Inferred from electronic annotation. Source: InterPro phospholipid binding Inferred from direct assay. Source: RGD protein binding Inferred from direct assay. Source: RGD signal transducer activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Experimental info

Non-terminal residue

1090

EMBL AAZ23845.1

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Sequences

Sequence

Length

Mass (Da)

Tools

Q45QJ6-1 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 486BA0DBEB5DF549
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FASTA

1,090

124,149

        10         20         30         40         50         60 
MSLLNPVLLP PKVKAYLSQG ERFIKWDDET SIASPVILRV DPKGYYLYWT HQSKEMEFLD 

        70         80         90        100        110        120 
VTSIRDTRFG KFAKIPKSQK LREVFNMDFP DNHFLLKTFT VVSGPDMVGL TFHNFVSYKE 

       130        140        150        160        170        180 
NVGKDWAEDV LALAKHPMTA NASRSTFLDK ILVKLKMQLS PEGKIPVKNF FQMFPADRKR 

       190        200        210        220        230        240 
VEAALSACHL AKGKNDAINP EDFPESVYKS FLMSLCPRPE IDEIFTSYHA KAKPYMTKEH 

       250        260        270        280        290        300 
LTKFINQKQR DPRLNSLLFP PARPEQVQAL IDKYEPSGIN VQRGQLSPEG MVWFLCGPEN 

       310        320        330        340        350        360 
SVLAHDTLRI HQDMTQPLNH YFINSSHNTY LTAGQFSGPS SAEMYRQVLL SGCRCVELDC 

       370        380        390        400        410        420 
WKGKPPDEEP IITHGFTMTT DILFKEAVEA IAESAFKTSP YPVILSFENH VDSPRQQAKM 

       430        440        450        460        470        480 
AEYCRTMFGE TLLTEPLENF PLKPGMPLPS PEDLRGKILI KNKKNQFSGP ASPNKKPDGV 

       490        500        510        520        530        540 
SEGGFPSSVP VEEDTGWTAE DRTEVEEGEE EEEVEEEEEE ESGNLDEEEI KKMQSDEGTA 

       550        560        570        580        590        600 
GLEVTAYEEM SSLVNYIQPT KFISFEFSAQ KNRSYLVSSF TELKAYELLS KASMQFVDYN 

       610        620        630        640        650        660 
KRQMSRVYPK GTRMDSSNYM PQMFWNAGCQ MVALNFQTMD LPMQQNMALF EFNGQSGYLL 

       670        680        690        700        710        720 
KHEFMRRQDK QFNPFSVDRI DVVVATTLSI TVISGQFLSE RSVRTYVEVE LFGLPGDPKR 

       730        740        750        760        770        780 
RYRTKLSPTA NSINPVWKEE PFIFEKILVP ELASLRIAVM EEGGKFIGHR IIPINALHSG 

       790        800        810        820        830        840 
YHHLCLRSES NMPLTMPALF VFLEMKDYVP DTWADLTVAL ANPIKYFSAH DKKSVKLKEV 

       850        860        870        880        890        900 
TGSLPEKLFS GIPVASQSNG APVSAGNGST APGTKAKEEA TKEVAEPQTT SLEELRELKG 

       910        920        930        940        950        960 
VVKLQRRHEK ELRELERRGA RRWEELLQRG AAQLAELQDP AASCKLRPGK GSRKKRIVPC 

       970        980        990       1000       1010       1020 
EETIVVPREV LEGPDPRVQD LKDRLEQELQ QQGEEQYRSV LKRKEQHVTE QIAKMMELAR 

      1030       1040       1050       1060       1070       1080 
EKQAAELKSF KETSETDTKE MKKKLEAKRL ERIQAMTKVT TDKVAQERLK REINNSHIQE 

      1090 
VVQAVKQMTE

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References

[1]

"Genetic Similarity Between Spontaneously Hypertensive Rats and Wistar-Kyoto Rats in the Coding Regions of Signal Transduction Proteins."
Jackson E.K., Zhu C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: SHR EMBL AAZ23845.1 and WKY EMBL AAZ23844.1.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ120505 mRNA. Translation: AAZ23844.1. DQ120506 mRNA. Translation: AAZ23845.1.
IPI	IPI00203756.
UniGene	Rn.30033
3D structure databases
SMR	Q45QJ6. Positions 11-807, 880-1089.
ModBase	Search...
Protein-protein interaction databases
STRING	Q45QJ6.
Genome annotation databases
Ensembl	ENSRNOT00000011911; ENSRNOP00000011911; ENSRNOG00000008229; Rattus norvegicus. [Genome view]
Phylogenomic databases
HOVERGEN	Q45QJ6.
InParanoid	Q45QJ6.
Gene expression databases
ArrayExpress	Q45QJ6.
Genevestigator	Q45QJ6.
Family and domain databases
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR018029. C2_membr_targeting. IPR011992. EF-hand-like_dom. IPR015359. Phospholipase_C_EF-hand-like. IPR001192. Phospholipase_C_Pinositol-sp_C. IPR001711. Phospholipase_C_Pinositol-sp_Y. IPR016280. PLC-beta. IPR017946. PLC-like_Pdiesterase_TIM-brl. IPR000909. PLipase_C_PInositol-sp_X_dom. [Graphical view]
Gene3D	G3DSA:1.10.238.10. EF-Hand_type. 1 hit. G3DSA:3.20.20.190. PLC-like_Pdiesterase_TIM-brl. 1 hit.
Pfam	PF00168. C2. 1 hit. PF09279. efhand_like. 1 hit. PF00388. PI-PLC-X. 1 hit. PF00387. PI-PLC-Y. 1 hit. [Graphical view]
PIRSF	PIRSF000956. PLC-beta. 1 hit.
PRINTS	PR00390. PHPHLIPASEC.
SMART	SM00239. C2. 1 hit. SM00148. PLCXc. 1 hit. SM00149. PLCYc. 1 hit. [Graphical view]
PROSITE	PS50004. C2. 1 hit. PS50007. PIPLC_X_DOMAIN. 1 hit. PS50008. PIPLC_Y_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

Q45QJ6_RAT

Accession

Primary (citable) accession number: Q45QJ6

Entry history

Integrated into UniProtKB/TrEMBL:	September 13, 2005
Last sequence update:	September 13, 2005
Last modified:	February 9, 2010
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Entry information