Unreviewed, UniProtKB/TrEMBL Q45QJ4 (Q45QJ4_RAT)

Names and origin

Protein names

Submitted name:
    Phospholipase C beta 3 EMBL AAZ23847.1

Gene names

Name:

Plcb3 EMBL AAZ23847.1

Organism

Rattus norvegicus (Rat) EMBL AAZ23847.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1236 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Contains 1 C2 domain. RuleBase RU003412V0 Spearmint SPM018029 Contains 1 PI-PLC X-box domain. Spearmint SPM018029 Contains 1 PI-PLC Y-box domain. Spearmint SPM018029

Ontologies

Keywords
Molecular function	Transducer Spearmint SPM018029
Gene Ontology (GO)
Biological process	intracellular signaling cascade Inferred from electronic annotation. Source: InterPro lipid catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro phosphoinositide phospholipase C activity Inferred from electronic annotation. Source: InterPro signal transducer activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q45QJ4-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 0538E3043D22A99A	FASTA	1,236	139,669
	10 20 30 40 50 60 MAGARPGVHA LQLEPPTVVE TLRRGSKFIK WDEEASSRNL VTLRVDPNGF FLYWTGPNME 70 80 90 100 110 120 VDTLDISSIR DTRTGRYARL PKDPKIREVL GFGGPDTRLE EKLMTVVAGP DPVNTTFLNF 130 140 150 160 170 180 MAVQDDTVKV WSEELFKLAM NILAQNASRN TFLRKAYTKL KLQVNQDGRI PVKNILKMFS 190 200 210 220 230 240 ADKKRVETAL ESCGLNFNRS ESIRPDEFSL EIFERFLNKL CLRPDIDKIL LEIGAKGKPY 250 260 270 280 290 300 LTLEQLMDFI NQKQRDPRLN EVLYPPLRSS QARLLIEKYE PNKQFLERDQ MSMEGFSRYL 310 320 330 340 350 360 GGEENGILPL EALDLSMDMT QPLSAYFINS SHNTYLTAGQ LAGTSSVEMY RQALLWGCRC 370 380 390 400 410 420 VELDVWKGRP PEEEPFITHG FTMTTEVPLR DVLEAIAETA FKTSPYPVIL SFENHVDSAK 430 440 450 460 470 480 QQAKMAEYCR SIFGEALLID PLDKYPLSAG TPLPSPQDLM GRILVKNKKR HRPSTGVPDS 490 500 510 520 530 540 SVRKRPLEQS NSALSESSAA TEPSSPQLGS PSSDSCPGLS NGEEVGLEKT SLEPQKSLGE 550 560 570 580 590 600 EGLNRGPNVL MPDRDREDEE EDEEEEETTD PKKPTTDEGT ASSEVNATEE MSTLVNYVEP 610 620 630 640 650 660 VKFKSFEAAR KRNKCFEMSS FVETKAMEQL TKSPMEFVEY NKQQLSRIYP KGTRVDSSNY 670 680 690 700 710 720 MPQLFWNVGC QLVALNFQTL DLPMQLNAGV FEYNGRSGYL LKPEFMRRPD KSFDPFTEVI 730 740 750 760 770 780 VDGIVANALR VKVISGQFLS DRKVGIYVEV DMFGLPVDTR RKYRTRTSQG NSFNPVWDEE 790 800 810 820 830 840 PFDFPKVVLP TLASLRIAAF EEGGRFVGHR ILPVSAIRSG YHYVCLRNEA NQPLCLPALL 850 860 870 880 890 900 IYTEASDYIP DDHQDYAEAL INPIKHVSLM DQRAKQLAAL IGESEAQAST EMCQETPSQQ 910 920 930 940 950 960 QGSQLSSNPA PNPLDASPRW PPGPTTSPTS TSLSSPGQRD DLIASILSEV TPTPLEELRS 970 980 990 1000 1010 1020 HKAMVKLRSR QDRDLRELHK KHQRKAVALT RRLLDGLAQA RAEGKCRPSS SALSRATNVE 1030 1040 1050 1060 1070 1080 DVKEEEKEAA RQYREFQNRQ VQSLLELREA QADAETERRL EHLKQAQQRL REVVLDAHTT 1090 1100 1110 1120 1130 1140 QFKRLKELNE REKKELQKIL DRKRNNSISE AKTREKHKKE VELTEINRRH ITESVNSIRR 1150 1160 1170 1180 1190 1200 LEEAQKQRHE RLLAGQQQVL QQLVEEEPKL VAQLTQECQE QRERLPQEIR RCLLGETSEG 1210 1220 1230 LGDGPLVACA SNGHAAGSGG HQSGADSESQ EENTQL

References

[1]	"Genetic Similarity Between Spontaneously Hypertensive Rats and Wistar-Kyoto Rats in the Coding Regions of Signal Transduction Proteins." Jackson E.K., Zhu C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: SHR EMBL AAZ23847.1 and WKY EMBL AAZ23846.1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ120507 mRNA. Translation: AAZ23846.1. DQ120508 mRNA. Translation: AAZ23847.1.
IPI	IPI00209033.
RefSeq	NP_203501.1.
UniGene	Rn.16983
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q45QJ4.
Genome annotation databases
Ensembl	ENSRNOT00000028720; ENSRNOP00000028720; ENSRNOG00000021150; Rattus norvegicus. [Genome view]
GeneID	29322.
KEGG	rno:29322.
NMPDR	fig|10116.3.peg.3586.
Organism-specific databases
CTD	29322.
Phylogenomic databases
HOVERGEN	Q45QJ4.
Gene expression databases
ArrayExpress	Q45QJ4.
Genevestigator	Q45QJ4.
Family and domain databases
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_reg_CaLB. IPR018029. C2_membr_targeting. IPR011992. EF-Hand_type. IPR015359. Phospholipase_C_EF-hand-like. IPR001192. Phospholipase_C_Pinositol-sp_C. IPR000909. Phospholipase_C_Pinositol-sp_X. IPR001711. Phospholipase_C_Pinositol-sp_Y. IPR016280. PLC-beta. IPR014815. PLC-beta_C. IPR017946. PLC-like_Pdiesterase_TIM-brl. [Graphical view]
Gene3D	G3DSA:1.10.238.10. EF-Hand_type. 1 hit. G3DSA:3.20.20.190. PLC-like_Pdiesterase_TIM-brl. 1 hit.
Pfam	PF00168. C2. 1 hit. PF09279. efhand_like. 1 hit. PF00388. PI-PLC-X. 1 hit. PF00387. PI-PLC-Y. 1 hit. PF08703. PLC-beta_C. 1 hit. [Graphical view]
PIRSF	PIRSF000956. PLC-beta. 1 hit.
PRINTS	PR00390. PHPHLIPASEC.
ProDom	PD001202. PI_PLC_Y. 2 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00239. C2. 1 hit. SM00148. PLCXc. 1 hit. SM00149. PLCYc. 1 hit. [Graphical view]
PROSITE	PS50004. C2. 1 hit. PS50007. PIPLC_X_DOMAIN. 1 hit. PS50008. PIPLC_Y_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	608777.

Entry information

Entry name

Q45QJ4_RAT

Accession

Primary (citable) accession number: Q45QJ4

Entry history

Integrated into UniProtKB/TrEMBL:	September 13, 2005
Last sequence update:	September 13, 2005
Last modified:	November 3, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)