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Protein
Submitted name:

Arylamine N-acetyltransferase 1

Gene

Nat1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  • arylamine N-acetyltransferase activity Source: RGD
  • N-acetyltransferase activity Source: RGD
  • translation repressor activity Source: RGD

GO - Biological processi

  • aging Source: RGD
  • heart development Source: RGD
  • liver development Source: RGD
  • negative regulation of translation Source: GOC
  • response to thyroxine Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotationImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Arylamine N-acetyltransferase 1Imported (EC:2.3.1.5Imported)
Submitted name:
RCG54708, isoform CRA_bImported
Submitted name:
RCG54709Imported
Gene namesi
Name:Nat1Imported
Synonyms:Nat2Imported
ORF Names:rCG_54708Imported, rCG_54709Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi70490. Nat1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: RGD
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018854.

Family & Domainsi

Sequence similaritiesi

Belongs to the arylamine N-acetyltransferase family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000012054.
HOVERGENiHBG000165.
KOiK00622.
OMAiQFFARLH.

Family and domain databases

InterProiIPR001447. Arylamine_N-AcTrfase.
[Graphical view]
PANTHERiPTHR11786. PTHR11786. 1 hit.
PfamiPF00797. Acetyltransf_2. 1 hit.
[Graphical view]
PRINTSiPR01543. ANATRNSFRASE.

Sequencei

Sequence statusi: Complete.

Q45G71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIEAYFERI GYKNSVNKLD LATLTEVLQH QMRAVPFENL SMHCGEAMCL
60 70 80 90 100
GLEATFDHIV RKKRGGWCLQ VNHLLYWALT KMGFETTMLG GYVYITPVNK
110 120 130 140 150
YSSEMVHLLV QVTISDRNYI VDSAYGSSYQ MWEPLELTSG KDQPQVPAIF
160 170 180 190 200
RLTEENGTWY LDQIRREQDV PNQEFVNSDL LEKSKYRKIY SFTLEPRTIE
210 220 230 240 250
DFEYVNTYLQ TSPASVFVST SFCSLQTSEG VCCLIGSTLT SRRFSYKDNV
260 270 280 290
DLVEFKSLTE EEIEDVLKTT FGISLEKKFV PKHGELVFTI
Length:290
Mass (Da):33,437
Last modified:September 13, 2005 - v1
Checksum:i2897CC1F84B7D72A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ133344 Genomic DNA. Translation: AAZ53264.1.
DQ133345 Genomic DNA. Translation: AAZ53265.1.
DQ133346 Genomic DNA. Translation: AAZ53266.1.
DQ133347 Genomic DNA. Translation: AAZ53267.1.
DQ133348 Genomic DNA. Translation: AAZ53268.1.
DQ133349 Genomic DNA. Translation: AAZ53269.1.
DQ133350 Genomic DNA. Translation: AAZ53270.1.
DQ133351 Genomic DNA. Translation: AAZ53271.1.
DQ133352 Genomic DNA. Translation: AAZ53272.1.
DQ133353 Genomic DNA. Translation: AAZ53273.1.
DQ133354 Genomic DNA. Translation: AAZ53274.1.
DQ133355 Genomic DNA. Translation: AAZ53275.1.
CH474045 Genomic DNA. Translation: EDL75951.1.
CH474045 Genomic DNA. Translation: EDL75952.1.
CH474045 Genomic DNA. Translation: EDL75953.1.
RefSeqiNP_001032392.1. NM_001037315.1.
NP_001032393.1. NM_001037316.1.
NP_446305.1. NM_053853.2.
XP_006253063.1. XM_006253001.1.
XP_006253064.1. XM_006253002.2.
XP_006253065.1. XM_006253003.1.
XP_006253066.1. XM_006253004.2.
UniGeneiRn.37420.

Genome annotation databases

GeneIDi116631.
KEGGirno:116631.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ133344 Genomic DNA. Translation: AAZ53264.1.
DQ133345 Genomic DNA. Translation: AAZ53265.1.
DQ133346 Genomic DNA. Translation: AAZ53266.1.
DQ133347 Genomic DNA. Translation: AAZ53267.1.
DQ133348 Genomic DNA. Translation: AAZ53268.1.
DQ133349 Genomic DNA. Translation: AAZ53269.1.
DQ133350 Genomic DNA. Translation: AAZ53270.1.
DQ133351 Genomic DNA. Translation: AAZ53271.1.
DQ133352 Genomic DNA. Translation: AAZ53272.1.
DQ133353 Genomic DNA. Translation: AAZ53273.1.
DQ133354 Genomic DNA. Translation: AAZ53274.1.
DQ133355 Genomic DNA. Translation: AAZ53275.1.
CH474045 Genomic DNA. Translation: EDL75951.1.
CH474045 Genomic DNA. Translation: EDL75952.1.
CH474045 Genomic DNA. Translation: EDL75953.1.
RefSeqiNP_001032392.1. NM_001037315.1.
NP_001032393.1. NM_001037316.1.
NP_446305.1. NM_053853.2.
XP_006253063.1. XM_006253001.1.
XP_006253064.1. XM_006253002.2.
XP_006253065.1. XM_006253003.1.
XP_006253066.1. XM_006253004.2.
UniGeneiRn.37420.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018854.

Protocols and materials databases

DNASUi116631.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi116631.
KEGGirno:116631.

Organism-specific databases

CTDi9.
RGDi70490. Nat1.

Phylogenomic databases

GeneTreeiENSGT00390000012054.
HOVERGENiHBG000165.
KOiK00622.
OMAiQFFARLH.

Miscellaneous databases

NextBioi619321.

Family and domain databases

InterProiIPR001447. Arylamine_N-AcTrfase.
[Graphical view]
PANTHERiPTHR11786. PTHR11786. 1 hit.
PfamiPF00797. Acetyltransf_2. 1 hit.
[Graphical view]
PRINTSiPR01543. ANATRNSFRASE.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. "Tissue expression and genomic sequences of rat N-acetyltransferases rNat1, rNat2, rNat3, and Functional characterization of a novel rNat3*2 genetic variant."
    Walraven J.M., Barker D.F., Doll M.A., Hein D.W.
    Toxicol. Sci. 99:413-421(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ACIImported, BNImported, BUFImported, CDFImported, COPImported, DAImported, LEWImported, LOU/MImported, MWImported, PVGImported, SHRImported and WFImported.

Entry informationi

Entry nameiQ45G71_RAT
AccessioniPrimary (citable) accession number: Q45G71
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: June 24, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.