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Protein

Protein vav-1

Gene

vav-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as guanine nucleotide exchange factor (GEF) for Rho GTPase. Has a critical roles in the generation of rhythmic behaviors: feeding, defecation and ovulation by dynamically regulating the concentration of intracellular calcium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri610 – 664Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST55

GO - Molecular functioni

GO - Biological processi

  • intracellular signal transduction Source: InterPro
  • negative regulation of Notch signaling pathway Source: WormBase
  • positive regulation of locomotion Source: UniProtKB
  • regulation of Rho protein signal transduction Source: InterPro
  • regulation of vulval development Source: WormBase

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-CEL-114604 GPVI-mediated activation cascade
R-CEL-1433557 Signaling by SCF-KIT
R-CEL-193648 NRAGE signals death through JNK
R-CEL-194840 Rho GTPase cycle
R-CEL-3928665 EPH-ephrin mediated repulsion of cells
R-CEL-416482 G alpha (12/13) signalling events
R-CEL-4420097 VEGFA-VEGFR2 Pathway
R-CEL-445144 Signal transduction by L1
R-CEL-5218920 VEGFR2 mediated vascular permeability
R-CEL-912631 Regulation of signaling by CBL
SignaLinkiQ45FX5

Names & Taxonomyi

Protein namesi
Recommended name:
Protein vav-1
Gene namesi
Name:vav-1
ORF Names:C35B8.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiC35B8.2a ; CE38040 ; WBGene00006887 ; vav-1
C35B8.2b ; CE39333 ; WBGene00006887 ; vav-1

Subcellular locationi

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi183Y → F: Leads to a dominant hypercontracted and uncoordinated phenotype; when associated with Y-200 and Y-217. 1 Publication1
Mutagenesisi200Y → F: Leads to a dominant hypercontracted and uncoordinated phenotype; when associated with Y-183 and Y-217. 1 Publication1
Mutagenesisi217Y → F: Leads to a dominant hypercontracted and uncoordinated phenotype. Leads to a dominant hypercontracted and uncoordinated phenotype; when associated with Y-183 and Y-200. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002387861 – 1007Protein vav-1Add BLAST1007

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei183PhosphotyrosineBy similarity1
Modified residuei200PhosphotyrosineBy similarity1
Modified residuei217PhosphotyrosineBy similarity1

Post-translational modificationi

GEF activity is regulated by phosphorylation on tyrosine residues.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ45FX5
PaxDbiQ45FX5
PeptideAtlasiQ45FX5
PRIDEiQ45FX5

PTM databases

iPTMnetiQ45FX5

Expressioni

Tissue specificityi

Strong expression in the pharynx, proximal gonad, spermatheca, intestine and rectal epithelia.1 Publication

Gene expression databases

BgeeiWBGene00006887

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi46070, 6 interactors
DIPiDIP-25959N
IntActiQ45FX5, 27 interactors
STRINGi6239.C35B8.2b

Structurei

3D structure databases

ProteinModelPortaliQ45FX5
SMRiQ45FX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 151Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST115
Domaini240 – 437DHPROSITE-ProRule annotationAdd BLAST198
Domaini470 – 598PHPROSITE-ProRule annotationAdd BLAST129
Domaini688 – 750SH3 1PROSITE-ProRule annotationAdd BLAST63
Domaini831 – 925SH2PROSITE-ProRule annotationAdd BLAST95
Domaini926 – 991SH3 2PROSITE-ProRule annotationAdd BLAST66

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni151 – 239ACAdd BLAST89

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi803 – 806Poly-Ser4
Compositional biasi1004 – 1007Poly-Ser4

Domaini

An acidic domain (AC) contains three highly conserved tyrosines that are involved in the autoinhibition of GEF activity.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri610 – 664Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST55

Keywords - Domaini

Repeat, SH2 domain, SH3 domain, Zinc-finger

Phylogenomic databases

eggNOGiKOG2996 Eukaryota
ENOG410XPH6 LUCA
GeneTreeiENSGT00910000144110
HOGENOMiHOG000020846
InParanoidiQ45FX5
KOiK05730
OMAiLGRVDNC
OrthoDBiEOG091G02W2
PhylomeDBiQ45FX5

Family and domain databases

CDDicd00029 C1, 1 hit
cd00014 CH, 1 hit
cd01223 PH_Vav, 1 hit
cd00160 RhoGEF, 1 hit
cd09940 SH2_Vav_family, 1 hit
Gene3Di1.10.418.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037832 PH_Vav
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR035031 Vav_SH2_invertebrate
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF00307 CH, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
PF00017 SH2, 1 hit
PF07653 SH3_2, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00033 CH, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00252 SH2, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
SSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 2 hits
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50001 SH2, 1 hit
PS50002 SH3, 2 hits
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: Q45FX5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRRSTTTST NFGLSWSLVD VISSSTAVFK VPMNGGCDLW IGCARWLRDM
60 70 80 90 100
KVLTTDKNGT MLEFASVLRD GILLCRLANT LVPNGIDQKK IMRTNQPSPF
110 120 130 140 150
LCCNNINYFA MFCKTYFNLE DADLFTAEDL YYMNGFQKVL KTLSFLSHTK
160 170 180 190 200
ESLSRGVDPF PDTDNNQEGT SNGSEFEDDV EIYQSLHDNI ENVDPNRTIY
210 220 230 240 250
GPITSADPEE QQSEQLYDRI VTNRKPSMNE NDLQNTPTLK RNRCIRELYD
260 270 280 290 300
TEKNYVAQAL VTIIKTFYEP LKGIIPTSDY NIIFGNIEEI NVLHTALLAD
310 320 330 340 350
LEYPVKVALG LSDATPPRPI SLNECVPQTI GEVFIKYRDQ FLAYGKYCSN
360 370 380 390 400
LPDSRKLSNE LLKTNEFISR NINELTAQGN CKFGMNDLLC VPFQRLTKYP
410 420 430 440 450
LLLKELQKKT DLASPDRKSL EEAVEVMEDV CNYINEESRD TNAIKVIDEI
460 470 480 490 500
EQSITDLSMP LNVKLHDYGR VNLDGEVKMA ESTLTQAGKP KQRYIFLFDK
510 520 530 540 550
VIVVCKAANK VMAAKTTGAS ARTNTFTYKN AYVMSELTID KNASLDVKSG
560 570 580 590 600
GTITRRTQYV IIMTRDRNEN NEITQLTFYF KNEATRNNWM TALLLSKSNV
610 620 630 640 650
SPTDYLRDTN HKVAFHSFRV DVKNPATCDV CDKLMKGLQY QGYKCESCNM
660 670 680 690 700
SMHKECLGLK KCEAVRKSTH ETRSSQSFNC NRPRFHIHEG DIVVANSNST
710 720 730 740 750
PSDLSYLQFA KGDRIEVIKM QGHNRFTGCL INNRNRTGLV HLDHVSQSRT
760 770 780 790 800
TSMIGLSPID SPAGSIAPRV VRNESTVLPN KLLSDGSSRS LSGPHGSRSS
810 820 830 840 850
RNSSSSTING SMDSVPRQQD YVNTEISEFL WYMGEMERAK AESTLKGTPN
860 870 880 890 900
GTFLVRYSKN RKQTAISLSY KNDVKHMIIE QNSDGKVYLD EDYIFNSTVE
910 920 930 940 950
LVQYYRSNNL IEIFAALDTC LKNPYSQCKV FKAVHDYDAP SPNNEGKFLS
960 970 980 990 1000
FKTGDIVVLL DTVGEDRGWW KGQVNNKSGF FPLSYVKPYD PATEGSSSPV

TPTSSSS
Length:1,007
Mass (Da):113,554
Last modified:September 13, 2005 - v1
Checksum:i4B0E7A79C7BB2DFD
GO
Isoform b (identifier: Q45FX5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Show »
Length:975
Mass (Da):110,109
Checksum:iA0A0C4862F56F3B0
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0189921 – 32Missing in isoform b. CuratedAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ136172 mRNA Translation: AAZ66767.1
FO080787 Genomic DNA Translation: CCD66769.1
FO080787 Genomic DNA Translation: CCD66770.1
PIRiT15778
RefSeqiNP_001041222.1, NM_001047757.2 [Q45FX5-2]
NP_001041223.1, NM_001047758.1 [Q45FX5-1]
UniGeneiCel.7082

Genome annotation databases

EnsemblMetazoaiC35B8.2b; C35B8.2b; WBGene00006887 [Q45FX5-1]
GeneIDi181153
KEGGicel:CELE_C35B8.2
UCSCiC35B8.2a.1 c. elegans [Q45FX5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiVAV_CAEEL
AccessioniPrimary (citable) accession number: Q45FX5
Secondary accession number(s): Q18479
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: September 13, 2005
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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