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Protein

Butyrate kinase 1

Gene

buk1

Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of butyryl-CoA through butyryl phosphate to butyrate.By similarity

Catalytic activityi

ATP + butanoate = ADP + butanoyl phosphate.

Pathwayi: butanoate metabolism

This protein is involved in the pathway butanoate metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway butanoate metabolism and in Lipid metabolism.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • butyrate kinase activity Source: MENGO

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCACE272562:GJIH-3158-MONOMER.
MetaCyc:BUKCLOS-MONOMER.
UniPathwayiUPA00863.

Names & Taxonomyi

Protein namesi
Recommended name:
Butyrate kinase 1 (EC:2.7.2.7)
Short name:
BK 1
Short name:
BKI
Gene namesi
Name:buk1
Synonyms:buk
Ordered Locus Names:CA_C3075
OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Taxonomic identifieri272562 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000814 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 355355Butyrate kinase 1PRO_0000107657Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272562.CA_C3075.

Structurei

3D structure databases

ProteinModelPortaliQ45829.
SMRiQ45829. Positions 1-355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.Curated

Phylogenomic databases

eggNOGiENOG4105CKM. Bacteria.
COG3426. LUCA.
HOGENOMiHOG000096659.
KOiK00929.
OMAiGYLNTND.

Family and domain databases

HAMAPiMF_00542. Butyrate_kinase. 1 hit.
InterProiIPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
IPR011245. Butyrate_kin.
[Graphical view]
PANTHERiPTHR21060. PTHR21060. 1 hit.
PTHR21060:SF3. PTHR21060:SF3. 1 hit.
PfamiPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF036458. Butyrate_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR02707. butyr_kinase. 1 hit.
PROSITEiPS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q45829-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRLLIINPG STSTKIGIYD DEKEIFEKTL RHSAEEIEKY NTIFDQFQFR
60 70 80 90 100
KNVILDALKE ANIEVSSLNA VVGRGGLLKP IVSGTYAVNQ KMLEDLKVGV
110 120 130 140 150
QGQHASNLGG IIANEIAKEI NVPAYIVDPV VVDELDEVSR ISGMADIPRK
160 170 180 190 200
SIFHALNQKA VARRYAKEVG KKYEDLNLIV VHMGGGTSVG THKDGRVIEV
210 220 230 240 250
NNTLDGEGPF SPERSGGVPI GDLVRLCFSN KYTYEEVMKK INGKGGVVSY
260 270 280 290 300
LNTIDFKAVV DKALEGDKKC ALIYEAFTFQ VAKEIGKCST VLKGNVDAII
310 320 330 340 350
LTGGIAYNEH VCNAIEDRVK FIAPVVRYGG EDELLALAEG GLRVLRGEEK

AKEYK
Length:355
Mass (Da):38,942
Last modified:March 5, 2002 - v2
Checksum:iC229E9ED7F1B927C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti338 – 3381A → R in AAA75487 (PubMed:8244020).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14744 Genomic DNA. Translation: AAA75487.1.
AE001437 Genomic DNA. Translation: AAK81015.1.
PIRiD97278.
I40819.
RefSeqiNP_349675.1. NC_003030.1.
WP_010966356.1. NC_003030.1.

Genome annotation databases

EnsemblBacteriaiAAK81015; AAK81015; CA_C3075.
GeneIDi1119258.
KEGGicac:CA_C3075.
PATRICi32040559. VBICloAce74127_3258.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14744 Genomic DNA. Translation: AAA75487.1.
AE001437 Genomic DNA. Translation: AAK81015.1.
PIRiD97278.
I40819.
RefSeqiNP_349675.1. NC_003030.1.
WP_010966356.1. NC_003030.1.

3D structure databases

ProteinModelPortaliQ45829.
SMRiQ45829. Positions 1-355.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272562.CA_C3075.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK81015; AAK81015; CA_C3075.
GeneIDi1119258.
KEGGicac:CA_C3075.
PATRICi32040559. VBICloAce74127_3258.

Phylogenomic databases

eggNOGiENOG4105CKM. Bacteria.
COG3426. LUCA.
HOGENOMiHOG000096659.
KOiK00929.
OMAiGYLNTND.

Enzyme and pathway databases

UniPathwayiUPA00863.
BioCyciCACE272562:GJIH-3158-MONOMER.
MetaCyc:BUKCLOS-MONOMER.

Family and domain databases

HAMAPiMF_00542. Butyrate_kinase. 1 hit.
InterProiIPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
IPR011245. Butyrate_kin.
[Graphical view]
PANTHERiPTHR21060. PTHR21060. 1 hit.
PTHR21060:SF3. PTHR21060:SF3. 1 hit.
PfamiPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF036458. Butyrate_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR02707. butyr_kinase. 1 hit.
PROSITEiPS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBUK1_CLOAB
AccessioniPrimary (citable) accession number: Q45829
Secondary accession number(s): Q97EN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: March 5, 2002
Last modified: September 7, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.