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Q45726

- BLAC_BACTU

UniProt

Q45726 - BLAC_BACTU

Protein

Beta-lactamase

Gene

bla

Organism
Bacillus thuringiensis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    • Comment

    Functioni

    This protein is a beta-lactamase with a substrate specificity for penicillins.

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei92 – 921Acyl-ester intermediatePROSITE-ProRule annotation
    Active sitei188 – 1881Proton acceptorBy similarity

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC

    GO - Biological processi

    1. beta-lactam antibiotic catabolic process Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-lactamase (EC:3.5.2.6)
    Alternative name(s):
    Penicillinase
    Gene namesi
    Name:bla
    OrganismiBacillus thuringiensis
    Taxonomic identifieri1428 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 309281Beta-lactamasePRO_0000016976Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ45726.
    SMRiQ45726. Positions 55-308.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni254 – 2563Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the class-A beta-lactamase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR000871. Beta-lactam_class-A/D.
    IPR023650. Beta-lactam_class-A_AS.
    [Graphical view]
    PRINTSiPR00118. BLACTAMASEA.
    SUPFAMiSSF56601. SSF56601. 1 hit.
    PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q45726-1 [UniParc]FASTAAdd to Basket

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    MMILKNKRML KIGICVGILG LSITSLEAFT GGALQVEAKQ KTGQVKHKNQ    50
    ATHKEFSQLE KKFDARVGVY AIDTGTNQTI SYRSNERFAF ASTYKALAAG 100
    VLLQQNSIDT LNEVITFTKE DLVDYSPVTE KHVDTGMKLG EIAEAAVRSS 150
    DNTAGNILFN KIGGPKGYEK ALRKMGDRVT MSDRFETELN EAIPGDIRDT 200
    STAKRIATNL KAFTVGNALP AEKRKILTEW MKGNATGDKL IRAGVPTDWV 250
    VGDKSGAGSY GTRNDIAIVW PPNRAPIIIA ILSSKDEKEA SYDNQLIAEA 300
    TEVIVKALK 309
    Length:309
    Mass (Da):33,699
    Last modified:November 1, 1996 - v1
    Checksum:i9C10BE11213237C1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X83424 Genomic DNA. Translation: CAA58448.1.
    PIRiJC4117.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X83424 Genomic DNA. Translation: CAA58448.1 .
    PIRi JC4117.

    3D structure databases

    ProteinModelPortali Q45726.
    SMRi Q45726. Positions 55-308.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR000871. Beta-lactam_class-A/D.
    IPR023650. Beta-lactam_class-A_AS.
    [Graphical view ]
    PRINTSi PR00118. BLACTAMASEA.
    SUPFAMi SSF56601. SSF56601. 1 hit.
    PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of a beta-lactamase-encoding gene from the insect pathogen Bacillus thuringiensis."
      Zhang M.-Y., Loevgren A.
      Gene 158:83-86(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Bt13.

    Entry informationi

    Entry nameiBLAC_BACTU
    AccessioniPrimary (citable) accession number: Q45726
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3