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Q45726 (BLAC_BACTU) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase

EC=3.5.2.6
Alternative name(s):
Penicillinase
Gene names
Name:bla
OrganismBacillus thuringiensis
Taxonomic identifier1428 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein is a beta-lactamase with a substrate specificity for penicillins.

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Sequence similarities

Belongs to the class-A beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   DomainSignal
   Molecular functionHydrolase
Gene Ontology (GO)
   Biological_processbeta-lactam antibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Chain29 – 309281Beta-lactamase
PRO_0000016976

Regions

Region254 – 2563Substrate binding By similarity

Sites

Active site921Acyl-ester intermediate By similarity
Active site1881Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q45726 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 9C10BE11213237C1

FASTA30933,699
        10         20         30         40         50         60 
MMILKNKRML KIGICVGILG LSITSLEAFT GGALQVEAKQ KTGQVKHKNQ ATHKEFSQLE 

        70         80         90        100        110        120 
KKFDARVGVY AIDTGTNQTI SYRSNERFAF ASTYKALAAG VLLQQNSIDT LNEVITFTKE 

       130        140        150        160        170        180 
DLVDYSPVTE KHVDTGMKLG EIAEAAVRSS DNTAGNILFN KIGGPKGYEK ALRKMGDRVT 

       190        200        210        220        230        240 
MSDRFETELN EAIPGDIRDT STAKRIATNL KAFTVGNALP AEKRKILTEW MKGNATGDKL 

       250        260        270        280        290        300 
IRAGVPTDWV VGDKSGAGSY GTRNDIAIVW PPNRAPIIIA ILSSKDEKEA SYDNQLIAEA 


TEVIVKALK 

« Hide

References

[1]"Cloning and sequencing of a beta-lactamase-encoding gene from the insect pathogen Bacillus thuringiensis."
Zhang M.-Y., Loevgren A.
Gene 158:83-86(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Bt13.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X83424 Genomic DNA. Translation: CAA58448.1.
PIRJC4117.

3D structure databases

ProteinModelPortalQ45726.
SMRQ45726. Positions 55-308.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSPR00118. BLACTAMASEA.
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBLAC_BACTU
AccessionPrimary (citable) accession number: Q45726
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: October 16, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families