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Protein

Ferredoxin 7Fe

Gene

fdxA

Organism
Bacillus schlegelii
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi9 – 91Iron-sulfur 1 (3Fe-4S)
Metal bindingi17 – 171Iron-sulfur 1 (3Fe-4S)
Metal bindingi21 – 211Iron-sulfur 2 (4Fe-4S)
Metal bindingi40 – 401Iron-sulfur 2 (4Fe-4S)
Metal bindingi43 – 431Iron-sulfur 2 (4Fe-4S)
Metal bindingi46 – 461Iron-sulfur 2 (4Fe-4S)
Metal bindingi50 – 501Iron-sulfur 1 (3Fe-4S)

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferredoxin 7Fe
Alternative name(s):
Seven-iron ferredoxin
Gene namesi
Name:fdxA
OrganismiBacillus schlegelii
Taxonomic identifieri1484 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeHydrogenibacillus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi14 – 141D → C: Transformation from a 7S to 8S ferredoxin. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 7877Ferredoxin 7FePRO_0000159172Add
BLAST

Interactioni

Subunit structurei

Monomer.

Structurei

Secondary structure

1
78
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni8 – 114Combined sources
Turni18 – 203Combined sources
Beta strandi26 – 283Combined sources
Beta strandi30 – 356Combined sources
Turni37 – 393Combined sources
Helixi46 – 494Combined sources
Helixi51 – 533Combined sources
Beta strandi54 – 574Combined sources
Turni58 – 603Combined sources
Helixi63 – 7513Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BC6NMR-A2-78[»]
1BD6NMR-A2-78[»]
1BQXNMR-A2-78[»]
1BWENMR-A2-78[»]
ProteinModelPortaliQ45560.
SMRiQ45560. Positions 2-78.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ45560.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 29284Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini31 – 60304Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR000813. 7Fe_ferredoxin.
[Graphical view]
PfamiPF00037. Fer4. 1 hit.
[Graphical view]
PRINTSiPR00354. 7FE8SFRDOXIN.
PROSITEiPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q45560-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYVITEPCI GTKDASCVEV CPVDCIHEGE DQYYIDPDVC IDCGACEAVC
60 70
PVSAIYHEDF VPEEWKSYIQ KNRDFFKK
Length:78
Mass (Da):8,874
Last modified:January 23, 2007 - v2
Checksum:i3295879B2E8C2BAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D29804 Genomic DNA. Translation: BAA06187.1.
PIRiJC2496.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D29804 Genomic DNA. Translation: BAA06187.1.
PIRiJC2496.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BC6NMR-A2-78[»]
1BD6NMR-A2-78[»]
1BQXNMR-A2-78[»]
1BWENMR-A2-78[»]
ProteinModelPortaliQ45560.
SMRiQ45560. Positions 2-78.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ45560.

Family and domain databases

InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR000813. 7Fe_ferredoxin.
[Graphical view]
PfamiPF00037. Fer4. 1 hit.
[Graphical view]
PRINTSiPR00354. 7FE8SFRDOXIN.
PROSITEiPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and expression of the gene encoding the 7Fe type ferredoxin from a thermophilic hydrogen oxidizing bacterium, Bacillus schlegelii."
    Aono S., Nakamura S., Aono R., Okura I.
    Biochem. Biophys. Res. Commun. 201:938-942(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 43741 / DSM 2000 / MA-48.
  2. "Purification and characterization of a 7Fe ferredoxin from a thermophilic hydrogen-oxidizing bacterium, Bacillus schlegelii."
    Aono S., Kurita H., Uno S., Okura I.
    J. Biochem. 112:792-795(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  3. "Solution structure of the oxidized Fe7S8 ferredoxin from the thermophilic bacterium Bacillus schlegelii by 1H NMR spectroscopy."
    Aono S., Bentrop D., Bertini I., Donaire A., Luchinat C., Niikura Y., Rosato A.
    Biochemistry 37:9812-9826(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.
    Strain: ATCC 43741 / DSM 2000 / MA-48.
  4. "The D13C variant of Bacillus schlegelii 7Fe ferredoxin is an 8Fe ferredoxin as revealed by 1H-NMR spectroscopy."
    Aono S., Bentrop D., Bertini I., Luchinat C., Macinai R.
    FEBS Lett. 412:501-505(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF ASP-14.

Entry informationi

Entry nameiFER_BACSC
AccessioniPrimary (citable) accession number: Q45560
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.