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Protein

Choline-binding protein

Gene

opuBC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Member of a high affinity multicomponent binding-protein-dependent transport system for choline.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciBSUB:BSU33710-MONOMER.
BRENDAi3.6.3.32. 658.

Protein family/group databases

TCDBi3.A.1.12.3. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Choline-binding protein
Gene namesi
Name:opuBC
Synonyms:proX
Ordered Locus Names:BSU33710
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22PROSITE-ProRule annotationAdd BLAST22
ChainiPRO_000003184523 – 306Choline-binding proteinAdd BLAST284

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi23N-palmitoyl cysteineCurated1
Lipidationi23S-diacylglycerol cysteineCurated1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ45462.

Expressioni

Inductioni

Repressed by GbsR.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100018291.

Structurei

Secondary structure

1306
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi36 – 43Combined sources8
Helixi44 – 60Combined sources17
Beta strandi65 – 71Combined sources7
Helixi74 – 82Combined sources9
Beta strandi87 – 93Combined sources7
Helixi94 – 100Combined sources7
Helixi110 – 125Combined sources16
Beta strandi127 – 129Combined sources3
Beta strandi139 – 144Combined sources6
Helixi145 – 151Combined sources7
Helixi157 – 165Combined sources9
Beta strandi167 – 170Combined sources4
Helixi174 – 176Combined sources3
Beta strandi178 – 181Combined sources4
Helixi182 – 189Combined sources8
Beta strandi194 – 198Combined sources5
Helixi201 – 203Combined sources3
Helixi204 – 209Combined sources6
Beta strandi214 – 219Combined sources6
Helixi224 – 227Combined sources4
Beta strandi230 – 232Combined sources3
Beta strandi244 – 250Combined sources7
Helixi251 – 256Combined sources6
Helixi260 – 265Combined sources6
Turni266 – 269Combined sources4
Helixi273 – 284Combined sources12
Helixi290 – 300Combined sources11
Helixi302 – 304Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3R6UX-ray1.61A23-306[»]
ProteinModelPortaliQ45462.
SMRiQ45462.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OsmX family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108HQR. Bacteria.
COG1732. LUCA.
HOGENOMiHOG000015716.
InParanoidiQ45462.
KOiK05845.
OMAiKMDIALA.
PhylomeDBiQ45462.

Family and domain databases

InterProiIPR007210. ABC_Gly_betaine_transp_sub-bd.
[Graphical view]
PfamiPF04069. OpuAC. 1 hit.
[Graphical view]
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q45462-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRKYLKLMI GLALAATLTL SGCSLPGLSA AADQTIKIGA QSMSESEIIA
60 70 80 90 100
SMLGQLIEHH TDLKTTTIKN LGSNAVQQQA LMNGEIDIAA TRYTGDALTG
110 120 130 140 150
TLRMEPEKDP DKALALTQRE FKKRYDLKWY DSYGFDNTYA FTVSKELADQ
160 170 180 190 200
YHLETVSDVK KWAPQLKLGV DNYWMKLKGN GYQDFTKTYG MTFGGTYPMQ
210 220 230 240 250
IGLVYDAVKS GKMDIVLAYS TDGRIKSYGL KMLKDDKQFF PPYDCSPVVP
260 270 280 290 300
EKVLKEHPEL EGIIKKMLGK IDTATMQELN YEVDGNLKEP SVVAKEYLEK

HRYFES
Length:306
Mass (Da):34,401
Last modified:May 30, 2000 - v2
Checksum:i9D8B32E1F5E7AD0F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17 – 19TLT → MLP in AAB01534 (PubMed:7592481).Curated3
Sequence conflicti172 – 188NYWMK…DFTKT → KVLDEAQGERLSRFYEN in AAB01534 (PubMed:7592481).CuratedAdd BLAST17
Sequence conflicti263 – 268IIKKML → TIQKMI in AAB01534 (PubMed:7592481).Curated6
Sequence conflicti296 – 306EYLEKHRYFES → AIFRKAPLLRIVKGGRSQ in AAB01534 (PubMed:7592481).CuratedAdd BLAST11

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti8L → W in strain: ATCC 6633. 1
Natural varianti13A → T in strain: ATCC 6633. 1
Natural varianti32A → S in strain: ATCC 6633. 1
Natural varianti84G → R in strain: ATCC 6633. 1
Natural varianti111D → E in strain: ATCC 6633. 1
Natural varianti146E → K in strain: ATCC 6633. 1
Natural varianti155T → N in strain: ATCC 6633. 1
Natural varianti194G → S in strain: ATCC 6633. 1
Natural varianti252K → Q in strain: ATCC 6633. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38418 Genomic DNA. Translation: AAB01534.1.
AF008930 Genomic DNA. Translation: AAC14358.1.
AL009126 Genomic DNA. Translation: CAB15376.1.
PIRiA69670.
RefSeqiNP_391251.1. NC_000964.3.
WP_003228372.1. NZ_JNCM01000033.1.

Genome annotation databases

EnsemblBacteriaiCAB15376; CAB15376; BSU33710.
GeneIDi938475.
KEGGibsu:BSU33710.
PATRICi18978744. VBIBacSub10457_3535.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38418 Genomic DNA. Translation: AAB01534.1.
AF008930 Genomic DNA. Translation: AAC14358.1.
AL009126 Genomic DNA. Translation: CAB15376.1.
PIRiA69670.
RefSeqiNP_391251.1. NC_000964.3.
WP_003228372.1. NZ_JNCM01000033.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3R6UX-ray1.61A23-306[»]
ProteinModelPortaliQ45462.
SMRiQ45462.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100018291.

Protein family/group databases

TCDBi3.A.1.12.3. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiQ45462.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB15376; CAB15376; BSU33710.
GeneIDi938475.
KEGGibsu:BSU33710.
PATRICi18978744. VBIBacSub10457_3535.

Phylogenomic databases

eggNOGiENOG4108HQR. Bacteria.
COG1732. LUCA.
HOGENOMiHOG000015716.
InParanoidiQ45462.
KOiK05845.
OMAiKMDIALA.
PhylomeDBiQ45462.

Enzyme and pathway databases

BioCyciBSUB:BSU33710-MONOMER.
BRENDAi3.6.3.32. 658.

Family and domain databases

InterProiIPR007210. ABC_Gly_betaine_transp_sub-bd.
[Graphical view]
PfamiPF04069. OpuAC. 1 hit.
[Graphical view]
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOPUBC_BACSU
AccessioniPrimary (citable) accession number: Q45462
Secondary accession number(s): O34432
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: November 2, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.