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Protein

Choline-binding protein

Gene

opuBC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Member of a high affinity multicomponent binding-protein-dependent transport system for choline.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciBSUB:BSU33710-MONOMER.
BRENDAi3.6.3.32. 658.

Protein family/group databases

TCDBi3.A.1.12.3. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Choline-binding protein
Gene namesi
Name:opuBC
Synonyms:proX
Ordered Locus Names:BSU33710
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222PROSITE-ProRule annotationAdd
BLAST
Chaini23 – 306284Choline-binding proteinPRO_0000031845Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi23 – 231N-palmitoyl cysteineCurated
Lipidationi23 – 231S-diacylglycerol cysteineCurated

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ45462.

Expressioni

Inductioni

Repressed by GbsR.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100018291.

Structurei

Secondary structure

1
306
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi36 – 438Combined sources
Helixi44 – 6017Combined sources
Beta strandi65 – 717Combined sources
Helixi74 – 829Combined sources
Beta strandi87 – 937Combined sources
Helixi94 – 1007Combined sources
Helixi110 – 12516Combined sources
Beta strandi127 – 1293Combined sources
Beta strandi139 – 1446Combined sources
Helixi145 – 1517Combined sources
Helixi157 – 1659Combined sources
Beta strandi167 – 1704Combined sources
Helixi174 – 1763Combined sources
Beta strandi178 – 1814Combined sources
Helixi182 – 1898Combined sources
Beta strandi194 – 1985Combined sources
Helixi201 – 2033Combined sources
Helixi204 – 2096Combined sources
Beta strandi214 – 2196Combined sources
Helixi224 – 2274Combined sources
Beta strandi230 – 2323Combined sources
Beta strandi244 – 2507Combined sources
Helixi251 – 2566Combined sources
Helixi260 – 2656Combined sources
Turni266 – 2694Combined sources
Helixi273 – 28412Combined sources
Helixi290 – 30011Combined sources
Helixi302 – 3043Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3R6UX-ray1.61A23-306[»]
ProteinModelPortaliQ45462.
SMRiQ45462. Positions 32-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OsmX family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108HQR. Bacteria.
COG1732. LUCA.
HOGENOMiHOG000015716.
InParanoidiQ45462.
KOiK05845.
OMAiKMDIALA.
PhylomeDBiQ45462.

Family and domain databases

InterProiIPR007210. ABC_Gly_betaine_transp_sub-bd.
[Graphical view]
PfamiPF04069. OpuAC. 1 hit.
[Graphical view]
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q45462-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRKYLKLMI GLALAATLTL SGCSLPGLSA AADQTIKIGA QSMSESEIIA
60 70 80 90 100
SMLGQLIEHH TDLKTTTIKN LGSNAVQQQA LMNGEIDIAA TRYTGDALTG
110 120 130 140 150
TLRMEPEKDP DKALALTQRE FKKRYDLKWY DSYGFDNTYA FTVSKELADQ
160 170 180 190 200
YHLETVSDVK KWAPQLKLGV DNYWMKLKGN GYQDFTKTYG MTFGGTYPMQ
210 220 230 240 250
IGLVYDAVKS GKMDIVLAYS TDGRIKSYGL KMLKDDKQFF PPYDCSPVVP
260 270 280 290 300
EKVLKEHPEL EGIIKKMLGK IDTATMQELN YEVDGNLKEP SVVAKEYLEK

HRYFES
Length:306
Mass (Da):34,401
Last modified:May 30, 2000 - v2
Checksum:i9D8B32E1F5E7AD0F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 193TLT → MLP in AAB01534 (PubMed:7592481).Curated
Sequence conflicti172 – 18817NYWMK…DFTKT → KVLDEAQGERLSRFYEN in AAB01534 (PubMed:7592481).CuratedAdd
BLAST
Sequence conflicti263 – 2686IIKKML → TIQKMI in AAB01534 (PubMed:7592481).Curated
Sequence conflicti296 – 30611EYLEKHRYFES → AIFRKAPLLRIVKGGRSQ in AAB01534 (PubMed:7592481).CuratedAdd
BLAST

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti8 – 81L → W in strain: ATCC 6633.
Natural varianti13 – 131A → T in strain: ATCC 6633.
Natural varianti32 – 321A → S in strain: ATCC 6633.
Natural varianti84 – 841G → R in strain: ATCC 6633.
Natural varianti111 – 1111D → E in strain: ATCC 6633.
Natural varianti146 – 1461E → K in strain: ATCC 6633.
Natural varianti155 – 1551T → N in strain: ATCC 6633.
Natural varianti194 – 1941G → S in strain: ATCC 6633.
Natural varianti252 – 2521K → Q in strain: ATCC 6633.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38418 Genomic DNA. Translation: AAB01534.1.
AF008930 Genomic DNA. Translation: AAC14358.1.
AL009126 Genomic DNA. Translation: CAB15376.1.
PIRiA69670.
RefSeqiNP_391251.1. NC_000964.3.
WP_003228372.1. NZ_JNCM01000033.1.

Genome annotation databases

EnsemblBacteriaiCAB15376; CAB15376; BSU33710.
GeneIDi938475.
KEGGibsu:BSU33710.
PATRICi18978744. VBIBacSub10457_3535.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38418 Genomic DNA. Translation: AAB01534.1.
AF008930 Genomic DNA. Translation: AAC14358.1.
AL009126 Genomic DNA. Translation: CAB15376.1.
PIRiA69670.
RefSeqiNP_391251.1. NC_000964.3.
WP_003228372.1. NZ_JNCM01000033.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3R6UX-ray1.61A23-306[»]
ProteinModelPortaliQ45462.
SMRiQ45462. Positions 32-305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100018291.

Protein family/group databases

TCDBi3.A.1.12.3. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiQ45462.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB15376; CAB15376; BSU33710.
GeneIDi938475.
KEGGibsu:BSU33710.
PATRICi18978744. VBIBacSub10457_3535.

Phylogenomic databases

eggNOGiENOG4108HQR. Bacteria.
COG1732. LUCA.
HOGENOMiHOG000015716.
InParanoidiQ45462.
KOiK05845.
OMAiKMDIALA.
PhylomeDBiQ45462.

Enzyme and pathway databases

BioCyciBSUB:BSU33710-MONOMER.
BRENDAi3.6.3.32. 658.

Family and domain databases

InterProiIPR007210. ABC_Gly_betaine_transp_sub-bd.
[Graphical view]
PfamiPF04069. OpuAC. 1 hit.
[Graphical view]
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOPUBC_BACSU
AccessioniPrimary (citable) accession number: Q45462
Secondary accession number(s): O34432
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: September 7, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.