ID   MTLD_BACST              Reviewed;         382 AA.
AC   Q45421;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   16-JUN-2009, entry version 46.
DE   RecName: Full=Mannitol-1-phosphate 5-dehydrogenase;
DE            EC=1.1.1.17;
GN   Name=mtlD;
OS   Bacillus stearothermophilus (Geobacillus stearothermophilus).
OC   Bacteria; Firmicutes; Bacillales; Bacillaceae; Geobacillus.
OX   NCBI_TaxID=1422;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 29609 / DSM 2027 / NCA 1503 / NCIB 8924;
RX   MEDLINE=96421984; PubMed=8824601;
RA   Henstra S.A., Tolner B., ten Hoeve Duurkens R.H., Konings W.N.,
RA   Robillard G.T.;
RT   "Cloning, expression, and isolation of the mannitol transport protein
RT   from the thermophilic bacterium Bacillus stearothermophilus.";
RL   J. Bacteriol. 178:5586-5591(1996).
CC   -!- CATALYTIC ACTIVITY: D-mannitol 1-phosphate + NAD(+) = D-fructose
CC       6-phosphate + NADH.
CC   -!- SIMILARITY: Belongs to the mannitol dehydrogenase family.
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DR   EMBL; U18943; AAC44466.1; -; Genomic_DNA.
DR   BRENDA; 1.1.1.17; 266715.
DR   GO; GO:0050662; F:coenzyme binding; IEA:InterPro.
DR   GO; GO:0008926; F:mannitol-1-phosphate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00196; -; 1.
DR   InterPro; IPR013328; DH_multihelical.
DR   InterPro; IPR013118; Mannitol_DH_C.
DR   InterPro; IPR000669; Mannitol_DH_core.
DR   InterPro; IPR013131; Mannitol_DH_N.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Gene3D; G3DSA:1.10.1040.10; Opine_DH; 1.
DR   Pfam; PF01232; Mannitol_dh; 1.
DR   Pfam; PF08125; Mannitol_dh_C; 1.
DR   PRINTS; PR00084; MTLDHDRGNASE.
DR   PROSITE; PS00974; MANNITOL_DHGENASE; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase.
FT   CHAIN         1    382       Mannitol-1-phosphate 5-dehydrogenase.
FT                                /FTId=PRO_0000170697.
FT   NP_BIND       3     14       NAD (By similarity).
SQ   SEQUENCE   382 AA;  43168 MW;  6A60B887A8C20052 CRC64;
     MLAVHFGAGN IGRGFIGSLL SQSGYEVVFV DINDELVRLL KEKQEYRVII ADENRQELLI
     RNVSAVNSQT EREKVIDYIT KAHLITTAVG PHILPAIATI LAEGLQKRIT INKTPLHIIA
     CENMIGGSDV LKSHVFEKIS EADKPLFEKY YGFLNCAVDR IVPNQKHDDP LSVVVEPFFE
     WVIEKRNIIG AIPPIQGAHF VDDLKPYIER KLFTVNTGHA IASYLGYYKK LQTIQEAMCD
     QEIRSDVEKA LHESGAVLVK KYGWNENEHQ SYIQKIIQRF INPSISDEVV RVARSPIRKL
     GANDRLIGPA TQYYDLFGQV PHGLVKGIAA LLLFDYENDE EAVALQKTIQ ETGVEGALYQ
     YSQLEKDHPL VIAIKDQWQH LK
//