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Protein

RNA polymerase sigma factor SigA

Gene

sigA

Organism
Corynebacterium glutamicum (Brevibacterium saccharolyticum)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.SAAS annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi458 – 477H-T-H motifUniRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation, Sigma factorUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase sigma factor SigAUniRule annotation
Gene namesi
Name:sigAUniRule annotationImported
OrganismiCorynebacterium glutamicum (Brevibacterium saccharolyticum)Imported
Taxonomic identifieri1718 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Interacts transiently with the RNA polymerase catalytic core.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ45302.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini288 – 301RNA_pol_sigma70InterPro annotationAdd BLAST14

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni264 – 334Sigma-70 factor domain-2UniRule annotationAdd BLAST71
Regioni343 – 419Sigma-70 factor domain-3UniRule annotationAdd BLAST77
Regioni432 – 485Sigma-70 factor domain-4UniRule annotationAdd BLAST54

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi288 – 291Interaction with polymerase core subunit RpoCUniRule annotation4

Phylogenomic databases

eggNOGiENOG4105DG1. Bacteria.
COG0568. LUCA.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
HAMAPiMF_00963. Sigma70_RpoD_SigA. 1 hit.
InterProiView protein in InterPro
IPR014284. RNA_pol_sigma-70_dom.
IPR000943. RNA_pol_sigma70.
IPR009042. RNA_pol_sigma70_r1_2.
IPR007627. RNA_pol_sigma70_r2.
IPR007624. RNA_pol_sigma70_r3.
IPR007630. RNA_pol_sigma70_r4.
IPR013325. RNA_pol_sigma_r2.
IPR013324. RNA_pol_sigma_r3_r4.
IPR012760. RNA_pol_sigma_RpoD_C.
IPR028630. Sigma70_RpoD.
IPR036388. WH-like_DNA-bd_sf.
PfamiView protein in Pfam
PF00140. Sigma70_r1_2. 1 hit.
PF04542. Sigma70_r2. 1 hit.
PF04539. Sigma70_r3. 1 hit.
PF04545. Sigma70_r4. 1 hit.
PRINTSiPR00046. SIGMA70FCT.
SUPFAMiSSF88659. SSF88659. 2 hits.
SSF88946. SSF88946. 1 hit.
TIGRFAMsiTIGR02393. RpoD_Cterm. 1 hit.
TIGR02937. sigma70-ECF. 1 hit.
PROSITEiView protein in PROSITE
PS00715. SIGMA70_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q45302-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESSMVENNV AKKTVAKKTA RKTARKAAPR VATPLESHPI SATPARSIDG
60 70 80 90 100
TSTPVEAADT IETTAPAAKA PAAKAPAKKV AKKTARKAPA KKTVAKKATT
110 120 130 140 150
AKAAPATAKD ENAPVDDDEE NLAQDEQDFD GDDFVDGIED EEDEDEDGVE
160 170 180 190 200
ALGEESEDDE EDGSSVWDED ESATLRQARK DAELTASADS VRAYLKQIGK
210 220 230 240 250
VALLNAEQEV SLAKRIEAGL YATHRMEEME EAFAAGDKDA KLTPAVKRDL
260 270 280 290 300
RAIARDGRKA KNHLLEANLR LVVSLAKRYT GRGMAFLDLI QEGNLGLIRA
310 320 330 340 350
VEKFDYSKGY KFSTYATWWI RQAITRAMAD QARTIRIPVH MVEVINKLGR
360 370 380 390 400
IQRELLQELG REPTPQELSK EMDISEEKVL EIQQYAREPI SLDQTIGDEG
410 420 430 440 450
DSQLGDFIED SEAVVAVDAV SFTLLQDQLQ DVLETLSERE AGVVKLRFGL
460 470 480 490
TDGMPRTLDE IGQVYGVTRE RIRQIESKTM SKRRHPSRSQ VLRDYLD
Length:497
Mass (Da):54,882
Last modified:November 1, 1996 - v1
Checksum:i93CFA5DED3785C45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49822 Genomic DNA. Translation: CAA89984.1.

Similar proteinsi

Entry informationi

Entry nameiQ45302_CORGT
AccessioniPrimary (citable) accession number: Q45302
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 25, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)