ID   GALE_CORGL              Reviewed;         329 AA.
AC   Q45291;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2002, sequence version 2.
DT   16-JUN-2009, entry version 59.
DE   RecName: Full=UDP-glucose 4-epimerase;
DE            EC=5.1.3.2;
DE   AltName: Full=UDP-galactose 4-epimerase;
DE   AltName: Full=Galactowaldenase;
GN   Name=galE; OrderedLocusNames=Cgl1921, cg2104;
OS   Corynebacterium glutamicum (Brevibacterium flavum).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Corynebacteriaceae; Corynebacterium.
OX   NCBI_TaxID=1718;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 13869 / DSMZ 1412 / NCIMB 9567;
RX   MEDLINE=97080508; PubMed=8921853; DOI=10.1016/0378-1119(96)00283-1;
RA   Oguiza J.A., Marcos A.T., Malumbres M., Martin J.F.;
RT   "The galE gene encoding the UDP-galactose 4-epimerase of
RT   Brevibacterium lactofermentum is coupled transcriptionally to the dmdR
RT   gene.";
RL   Gene 177:103-107(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025;
RA   Nakagawa S.;
RT   "Complete genomic sequence of Corynebacterium glutamicum ATCC 13032.";
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025;
RX   MEDLINE=22830012; PubMed=12948626; DOI=10.1016/S0168-1656(03)00154-8;
RA   Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M.,
RA   Burkovski A., Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L.,
RA   Goesmann A., Hartmann M., Huthmacher K., Kraemer R., Linke B.,
RA   McHardy A.C., Meyer F., Moeckel B., Pfefferle W., Puehler A.,
RA   Rey D.A., Rueckert C., Rupp O., Sahm H., Wendisch V.F., Wiegraebe I.,
RA   Tauch A.;
RT   "The complete Corynebacterium glutamicum ATCC 13032 genome sequence
RT   and its impact on the production of L-aspartate-derived amino acids
RT   and vitamins.";
RL   J. Biotechnol. 104:5-25(2003).
CC   -!- CATALYTIC ACTIVITY: UDP-glucose = UDP-galactose.
CC   -!- COFACTOR: NAD.
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the sugar epimerase family.
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DR   EMBL; Z49823; CAA89986.1; -; Genomic_DNA.
DR   EMBL; BA000036; BAB99314.1; -; Genomic_DNA.
DR   EMBL; BX927153; CAF20262.1; -; Genomic_DNA.
DR   PIR; JC5168; JC5168.
DR   RefSeq; NP_601127.1; -.
DR   RefSeq; YP_226163.1; -.
DR   HSSP; Q14376; 1EK6.
DR   GeneID; 1019878; -.
DR   GeneID; 3343869; -.
DR   GenomeReviews; BA000036_GR; Cgl1921.
DR   GenomeReviews; BX927147_GR; cg2104.
DR   KEGG; cgb:cg2104; -.
DR   KEGG; cgl:NCgl1846; -.
DR   HOGENOM; Q45291; -.
DR   OMA; Q45291; DPQVPTN.
DR   BioCyc; CGLU196627-1:CG2104-MON; -.
DR   BRENDA; 5.1.3.2; 812.
DR   GO; GO:0050662; F:coenzyme binding; IEA:InterPro.
DR   GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:EC.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR005886; GalE.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR10366:SF39; GalE; 1.
DR   Pfam; PF01370; Epimerase; 1.
DR   TIGRFAMs; TIGR01179; galE; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Complete proteome; Galactose metabolism;
KW   Isomerase; NAD.
FT   CHAIN         1    329       UDP-glucose 4-epimerase.
FT                                /FTId=PRO_0000183202.
FT   NP_BIND       2     33       NAD (By similarity).
FT   ACT_SITE    139    139       Proton acceptor (By similarity).
FT   BINDING     115    115       Substrate (By similarity).
FT   CONFLICT     16     16       A -> R (in Ref. 1; CAA89986).
FT   CONFLICT     61     61       S -> L (in Ref. 1; CAA89986).
FT   CONFLICT    201    201       T -> I (in Ref. 1; CAA89986).
SQ   SEQUENCE   329 AA;  35263 MW;  3411E25C83DBC553 CRC64;
     MKLLVTGGAG YVGSVAAAVL LEHGHDVTII DNFSTGNREA VPADARLIEG DVNDVVEEVL
     SEGGFEGVVH FAARSLVGES VEKPNEYWHD NVVTALTLLD AMRAHGVNNL VFSSTAATYG
     EPDVVPITED MPTQPTNAYG ATKLSIDYAI TSYAAAFGLA ATSLRYFNVA GAYGNIGENR
     EVETHLIPLV LQVATGHREK TFMFGDDWPT PDGTAVRDYI HILDLAKAHV LALESNEAGK
     HRIFNLGSGD GYSVKQVVEM CREVTGHPIP AEVAPRRAGD PATLIASSEK AKQELGWTPE
     HTDLRTIVED AWAFTSALGD RSHAAKKKA
//