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Q45101

- O16G_BACCO

UniProt

Q45101 - O16G_BACCO

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Protein

Oligo-1,6-glucosidase

Gene

malL

Organism
Bacillus coagulans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei199 – 1991NucleophileBy similarity
Active sitei255 – 2551Proton donorBy similarity
Sitei332 – 3321Transition state stabilizerBy similarity

GO - Molecular functioni

  1. cation binding Source: InterPro
  2. oligo-1,6-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-3141-MONOMER.
RETL1328306-WGS:GSTH-712-MONOMER.

Protein family/group databases

CAZyiGH13. Glycoside Hydrolase Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
Oligo-1,6-glucosidase (EC:3.2.1.10)
Alternative name(s):
Dextrin 6-alpha-D-glucanohydrolase
Oligosaccharide alpha-1,6-glucosidase
Sucrase-isomaltase
Short name:
Isomaltase
Gene namesi
Name:malL
OrganismiBacillus coagulans
Taxonomic identifieri1398 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Oligo-1,6-glucosidasePRO_0000054314Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ45101.
SMRiQ45101. Positions 2-554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 13 family.Curated

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR022567. DUF3459.
IPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 1 hit.
PF11941. DUF3459. 1 hit.
[Graphical view]
SMARTiSM00642. Aamy. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Q45101-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEWWKKAVV YQIYPRSFYD TNGDGIGDLR GIMDKLDYLK TLGIDCIWIS
60 70 80 90 100
PVYDSPQDDN GYDIRDYRKI DKMFGTNEDM DRLLDEAHAR GIKIVMDLVV
110 120 130 140 150
NHTSDEHAWF VESRKSKDNP YRDFYFWKDP KPDGTPPNNW GSMFSGSAWE
160 170 180 190 200
YDETTGQYYL HYFSKKQPDL NWENEKVRKE IYDMMKFWMD KGVDGWRMDV
210 220 230 240 250
IGSISKFLDF PDYELPEGQK YGIGKYHANG PRLHAFIQEM NREVLSKYDC
260 270 280 290 300
MTVGEAIGSD VEIARKYTGP DRHELNMIFN FEHMDVDTKP GSPAGKWALK
310 320 330 340 350
PFDLVELKQI LSRWQYELAD TGWNALYFEN HDQARVVSRW GNDTTYRAEC
360 370 380 390 400
AKAFATILHG LKGTPFIYQG EEIGMVNADL ELEEYDDIEI RNAYQELVME
410 420 430 440 450
NQIMSKDEFL TAVRKKGRDN ARTPMQWDGS FNAGFTTGTP WLKVNSRYSE
460 470 480 490 500
INVAKALQEP DSIFYYYQSL IKLRHSYDVF TDGRYELLMP DHPHLYVYTR
510 520 530 540 550
ENESEKLLVA ANLSENTVSF DQPDDNWKLL LGNYEDTGTS TLFRPYEAAI

YYLEK
Length:555
Mass (Da):64,991
Last modified:November 1, 1996 - v1
Checksum:iCE2BB1D7B4E226D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78342 Genomic DNA. Translation: BAA11354.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78342 Genomic DNA. Translation: BAA11354.1 .

3D structure databases

ProteinModelPortali Q45101.
SMRi Q45101. Positions 2-554.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH13. Glycoside Hydrolase Family 13.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BioCyci RETL1328306-WGS:GSTH-3141-MONOMER.
RETL1328306-WGS:GSTH-712-MONOMER.

Family and domain databases

Gene3Di 2.60.40.1180. 1 hit.
3.20.20.80. 2 hits.
InterProi IPR022567. DUF3459.
IPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10357. PTHR10357. 1 hit.
Pfami PF00128. Alpha-amylase. 1 hit.
PF11941. DUF3459. 1 hit.
[Graphical view ]
SMARTi SM00642. Aamy. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Analysis of the critical sites for protein thermostabilization by proline substitution in oligo-1,6-glucosidase from Bacillus coagulans ATCC 7050 and the evolutionary consideration of proline residues."
    Watanabe K., Kitamura K., Suzuki Y.
    Appl. Environ. Microbiol. 62:2066-2073(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 7050 / DSM 1 / JCM 2257 / NCIB 9365 / NCTC 10334.

Entry informationi

Entry nameiO16G_BACCO
AccessioniPrimary (citable) accession number: Q45101
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3