Reviewed, UniProtKB/Swiss-Prot Q45072 (TFTE_BURCE)

Names and origin

Protein names

Recommended name:
    Maleylacetate reductase
    EC=1.3.1.32

Gene names

Name:

tftE

Organism

Burkholderia cepacia (Pseudomonas cepacia)

Taxonomic identifier

292 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	352 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-oxoadipate + NAD(P)(+) = 2-maleylacetate + NAD(P)H.
Pathway	Xenobiotic degradation; 2,4,5-trichlorophenoxyacetic acid degradation.
Sequence similarities	Belongs to the iron-containing alcohol dehydrogenase family.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	aromatic compound catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	maleylacetate reductase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 352	352	Maleylacetate reductase		PRO_0000087853

Sequences

	Sequence		Length	Mass (Da)
	Q45072-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: FD7F0F8959357044	FASTA	352	36,823
	10 20 30 40 50 60 MNAFLFEARI PRVVFGAGAL QHLVREIDAM GSTRALVLST PEQSADAERV AGILGSRAVG 70 80 90 100 110 120 VFPRATMHVP IELAREARLE ASRLGADCAV AIGGGSTTGL GKAIALESGL PILSIPTTYA 130 140 150 160 170 180 GSEMTPIYGV TDNGVKQTGR DARVLPRTVI YDPELTLGLP IRMTVSSGLN AIAHAAESLY 190 200 210 220 230 240 AHDGNPVIGL MAEEGIRAIG AALTPLQANP ADLVARSDAL YGAWLCGAVL GAVSMGLHHK 250 260 270 280 290 300 LCHTLGGAFN LPHAELHTVI LPHALAYNSA RASQAMERIA RALGVSSAPR GLFDLAERSG 310 320 330 340 350 LPVSLAALGM PREGIELAAD MAVKNPYPNP RPLERDAIRV LLEHAYDGVR PS

References

[1]

"Sequence analysis of a gene cluster involved in metabolism of 2,4,5-trichlorophenoxyacetic acid by Burkholderia cepacia AC1100." Daubaras D.L., Hershberger C.D., Kitano K., Chakrabarty A.M. Appl. Environ. Microbiol. 61:1279-1289(1995) [PubMed: 7538273] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: AC1100.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U19883 Genomic DNA. Translation: AAC43333.1.
PIR	I40177.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR001670. Fe_AlcDHase. [Graphical view]
Pfam	PF00465. Fe-ADH. 1 hit. [Graphical view]
PROSITE	PS00913. ADH_IRON_1. False negative. PS00060. ADH_IRON_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TFTE_BURCE

Accession

Primary (citable) accession number: Q45072

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1996
Last modified:	November 25, 2008
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)