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Protein

Sensor protein GtcS

Gene

gtcS

Organism
Aneurinibacillus migulanus (Bacillus migulanus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Member of the two-component regulatory system GtcS/GtcR which may act in the control of the transcription of the grs operon which encodes the multienzymes involved in the biosynthesis of the peptide antibiotic gramicidin S. Probably activates GtcR by phosphorylation.

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Two-component regulatory system

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sensor protein GtcS (EC:2.7.13.3)
Gene namesi
Name:gtcS
OrganismiAneurinibacillus migulanus (Bacillus migulanus)
Taxonomic identifieri47500 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaeAneurinibacillus groupAneurinibacillus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221HelicalSequence analysisAdd
BLAST
Transmembranei40 – 6021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Sensor protein GtcSPRO_0000074769Add
BLAST

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ44930.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini66 – 11853HAMPPROSITE-ProRule annotationAdd
BLAST
Domaini133 – 355223Histidine kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HAMP domain.PROSITE-ProRule annotation
Contains 1 histidine kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q44930-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITAYILFTV TVGVTNSIVF YLDDHIGTRH FKKRVYCSSA WIVAWRLMEM
60 70 80 90 100
VIFALSVYLY SRWTSKRITG PLEKITDAIQ KMREGEFAQR LCFKADYELT
110 120 130 140 150
LIQEHFNEMV AHLEKTEAEK NKLEQSKQRM LLDLSHDFKT PITTIQGYAM
160 170 180 190 200
ALQMGVVDSP EKQRRYLEMI YNKSIIVTAL VEDMFQLATL DSPDLPSAEE
210 220 230 240 250
HGRFGRTGSE IAIAYFDQFE QNKFSLDLKI PTQRVMIRMN RNLLYRALSN
260 270 280 290 300
LLSNTLKHNP KGTKVALSLT DTHEAILLEV MDNGIGIAEE LKESIFQPFV
310 320 330 340 350
RGDKARTGEG TGLGLPSPKK RLNFMVESCC SRVNQGKQYS RSFSQRLEND
360 370
LPYRLPYHRM NKFHRNANQQ
Length:370
Mass (Da):42,758
Last modified:November 1, 1996 - v1
Checksum:i740D53F3006718CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78502 Genomic DNA. Translation: CAA55265.1.
PIRiI40085.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78502 Genomic DNA. Translation: CAA55265.1.
PIRiI40085.

3D structure databases

ProteinModelPortaliQ44930.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The gtcRS operon coding for two-component system regulatory proteins is located adjacent to the grs operon of Bacillus brevis."
    Turgay K., Marahiel M.A.
    DNA Seq. 5:283-290(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 9999 / DSM 2895 / JCM 8504 / NBRC 15520 / NCTC 7096.

Entry informationi

Entry nameiGTCS_ANEMI
AccessioniPrimary (citable) accession number: Q44930
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: November 1, 1996
Last modified: September 16, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.