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Protein

Sensor protein GtcS

Gene

gtcS

Organism
Aneurinibacillus migulanus (Bacillus migulanus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

Member of the two-component regulatory system GtcS/GtcR which may act in the control of the transcription of the grs operon which encodes the multienzymes involved in the biosynthesis of the peptide antibiotic gramicidin S. Probably activates GtcR by phosphorylation.

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
Biological processTwo-component regulatory system
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sensor protein GtcS (EC:2.7.13.3)
Gene namesi
Name:gtcS
OrganismiAneurinibacillus migulanus (Bacillus migulanus)
Taxonomic identifieri47500 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaeAneurinibacillus groupAneurinibacillus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000747691 – 370Sensor protein GtcSAdd BLAST370

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ44930.
SMRiQ44930.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 118HAMPPROSITE-ProRule annotationAdd BLAST53
Domaini133 – 355Histidine kinasePROSITE-ProRule annotationAdd BLAST223

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd06225. HAMP. 1 hit.
cd00075. HATPase_c. 1 hit.
cd00082. HisKA. 1 hit.
Gene3Di3.30.565.10. 1 hit.
InterProiView protein in InterPro
IPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR036890. HATPase_C_sf.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR036097. HisK_dim/P_sf.
IPR004358. Sig_transdc_His_kin-like_C.
PfamiView protein in Pfam
PF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PRINTSiPR00344. BCTRLSENSOR.
SMARTiView protein in SMART
SM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiView protein in PROSITE
PS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q44930-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITAYILFTV TVGVTNSIVF YLDDHIGTRH FKKRVYCSSA WIVAWRLMEM
60 70 80 90 100
VIFALSVYLY SRWTSKRITG PLEKITDAIQ KMREGEFAQR LCFKADYELT
110 120 130 140 150
LIQEHFNEMV AHLEKTEAEK NKLEQSKQRM LLDLSHDFKT PITTIQGYAM
160 170 180 190 200
ALQMGVVDSP EKQRRYLEMI YNKSIIVTAL VEDMFQLATL DSPDLPSAEE
210 220 230 240 250
HGRFGRTGSE IAIAYFDQFE QNKFSLDLKI PTQRVMIRMN RNLLYRALSN
260 270 280 290 300
LLSNTLKHNP KGTKVALSLT DTHEAILLEV MDNGIGIAEE LKESIFQPFV
310 320 330 340 350
RGDKARTGEG TGLGLPSPKK RLNFMVESCC SRVNQGKQYS RSFSQRLEND
360 370
LPYRLPYHRM NKFHRNANQQ
Length:370
Mass (Da):42,758
Last modified:November 1, 1996 - v1
Checksum:i740D53F3006718CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78502 Genomic DNA. Translation: CAA55265.1.
PIRiI40085.

Entry informationi

Entry nameiGTCS_ANEMI
AccessioniPrimary (citable) accession number: Q44930
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: November 1, 1996
Last modified: October 25, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program