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Protein

Carboxy-terminal-processing protease

Gene

ctpA

Organism
Bartonella bacilliformis (strain ATCC 35685 / KC583)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in protection of the bacterium from thermal and osmotic stresses.Curated

Catalytic activityi

The enzyme shows specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala, but then cleaves at a variable distance from the C-terminus. A typical cleavage is -Ala-Ala-|-Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei294 – 2941Charge relay systemBy similarity
Active sitei305 – 3051Charge relay systemBy similarity
Active sitei319 – 3191Charge relay systemBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciBBAC360095:GHRY-324-MONOMER.
RETL1328306-WGS:GSTH-4190-MONOMER.

Protein family/group databases

MEROPSiS41.004.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxy-terminal-processing protease (EC:3.4.21.102)
Short name:
C-terminal-processing protease
Gene namesi
Name:ctpA
Ordered Locus Names:BARBAKC583_0324
OrganismiBartonella bacilliformis (strain ATCC 35685 / KC583)
Taxonomic identifieri360095 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
Proteomesi
  • UP000000643 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 434411Carboxy-terminal-processing proteasePRO_0000027334Add
BLAST

Post-translational modificationi

May undergo autocatalytic processing at the C-terminus (398-434 or 425-434 missing).

Interactioni

Protein-protein interaction databases

STRINGi360095.BARBAKC583_0324.

Structurei

3D structure databases

ProteinModelPortaliQ44879.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini86 – 16681PDZPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S41A family.Curated
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105CN1. Bacteria.
COG0793. LUCA.
HOGENOMiHOG000038764.
KOiK03797.
OMAiRGEPNTK.
OrthoDBiPOG091H02IK.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.90.226.10. 2 hits.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR001478. PDZ.
IPR004447. Peptidase_S41A.
IPR005151. Tail-specific_protease.
[Graphical view]
PfamiPF13180. PDZ_2. 1 hit.
PF03572. Peptidase_S41. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00245. TSPc. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF52096. SSF52096. 2 hits.
TIGRFAMsiTIGR00225. prc. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q44879-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRKVIFFVA GVFLSASLIV MAQSITTNNE QNTYKQLARF GDIFERVRTQ
60 70 80 90 100
YVTIPDDQKL IENAINGMLL SLDPHSSYMD AEKAKDMRDS TKGEFGGLGI
110 120 130 140 150
EVTMENNLIK VVSPIDDTPA AKAGVLAGDF ISKIDGKQIS GQTLNEAVDQ
160 170 180 190 200
MRGPAGTPIT LTINRFGVDK PLDIKIVRDI IKVKAVKYRV EGDIGYLRLI
210 220 230 240 250
QFTEKTFSDL QAAIKDIQSK IPTDKLKGYV LDLRLNPGGL LDQAISVTDA
260 270 280 290 300
FLNKGEIVST RGRKQNDVMR FDAKLGDLTD EKPIIVLING GSASASEIVA
310 320 330 340 350
GALQDHRRAT IIGTQSFGKG SVQTIIPLGE NGALRLTTAL YYTPSGTSIQ
360 370 380 390 400
GIGITPDIVV EQPLPEKYKG YDVTLGESEL RGHIKGKQES DKGSGSAAFV
410 420 430
PRDPKDDVQL NEAYKLLRGE ITHAAFPPDP NKVF
Length:434
Mass (Da):47,269
Last modified:November 1, 1996 - v1
Checksum:i11B9924F27FE63A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37094 Genomic DNA. Translation: AAB61766.1.
CP000524 Genomic DNA. Translation: ABM45226.1.
U73652 Genomic DNA. Translation: AAB18238.1.
RefSeqiWP_005766244.1. NC_008783.1.

Genome annotation databases

EnsemblBacteriaiABM45226; ABM45226; BARBAKC583_0324.
GeneIDi4684069.
KEGGibbk:BARBAKC583_0324.
PATRICi20536917. VBIBarBac6912_0308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37094 Genomic DNA. Translation: AAB61766.1.
CP000524 Genomic DNA. Translation: ABM45226.1.
U73652 Genomic DNA. Translation: AAB18238.1.
RefSeqiWP_005766244.1. NC_008783.1.

3D structure databases

ProteinModelPortaliQ44879.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi360095.BARBAKC583_0324.

Protein family/group databases

MEROPSiS41.004.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM45226; ABM45226; BARBAKC583_0324.
GeneIDi4684069.
KEGGibbk:BARBAKC583_0324.
PATRICi20536917. VBIBarBac6912_0308.

Phylogenomic databases

eggNOGiENOG4105CN1. Bacteria.
COG0793. LUCA.
HOGENOMiHOG000038764.
KOiK03797.
OMAiRGEPNTK.
OrthoDBiPOG091H02IK.

Enzyme and pathway databases

BioCyciBBAC360095:GHRY-324-MONOMER.
RETL1328306-WGS:GSTH-4190-MONOMER.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.90.226.10. 2 hits.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR001478. PDZ.
IPR004447. Peptidase_S41A.
IPR005151. Tail-specific_protease.
[Graphical view]
PfamiPF13180. PDZ_2. 1 hit.
PF03572. Peptidase_S41. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00245. TSPc. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF52096. SSF52096. 2 hits.
TIGRFAMsiTIGR00225. prc. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTPA_BARBK
AccessioniPrimary (citable) accession number: Q44879
Secondary accession number(s): A1URP1, P70869
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.