Reviewed, UniProtKB/Swiss-Prot Q44856 (BDB_BRECH)

Names and origin

Protein names

Recommended name:
    Disulfide bond formation protein
Alternative name(s):
    Disulfide oxidoreductase
    Thiol-disulfide oxidoreductase

Gene names

Name:

bdb

Organism

Brevibacillus choshinensis

Taxonomic identifier

54911 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Paenibacillaceae › Brevibacillus

Protein attributes

Sequence length	118 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Stimulates the oxidation and reduction of disulfide bonds in vitro.
Subcellular location	Secreted. Note: Is found associated with the cell lysate, thought to be associated with the cell periphery.
Sequence similarities	Belongs to the thioredoxin family. Contains 1 thioredoxin domain.

Ontologies

Keywords
Cellular component	Secreted
Domain	Redox-active center Signal
Molecular function	Oxidoreductase
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Ref.1
	Chain	28 – 118	91	Disulfide bond formation protein		PRO_0000034284
Regions
	Domain	28 – 114	87	Thioredoxin
Amino acid modifications
	Disulfide bond	42 ↔ 45		Redox-active Probable

Sequences

	Sequence		Length	Mass (Da)
	Q44856-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: C81E7BD4E6177144	FASTA	118	13,326
	10 20 30 40 50 60 MRAKWLWMTA VGSLLITVLT AWGWAAASSQ DSKIVYVFSD SCGYCQTFRP TLETVLQEYP 70 80 90 100 110 QTSVERLDIR EERDLKEALR LGAEATPTIF VVRDGTVMDK LEGDVAEAVL RSFFQKKS

References

[1]

"Cloning and characterization of the gene for a protein thiol-disulfide oxidoreductase in Bacillus brevis." Ishihara T., Tomita H., Hasegawa Y., Tsukagoshi N., Yamagata H., Udaka S. J. Bacteriol. 177:745-749(1995) [PubMed: 7836310] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 28-38, CHARACTERIZATION. Strain: HPD31.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D37936 Genomic DNA. Translation: BAA07155.1.
PIR	I39787.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR017936. Thioredoxin-like. IPR015467. Thioredoxin_core. IPR017937. Thioredoxin_CS. IPR013766. Thioredoxin_domain. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR10438. Trx. 1 hit.
Pfam	PF00085. Thioredoxin. 1 hit. [Graphical view]
PROSITE	PS00194. THIOREDOXIN_1. False negative. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BDB_BRECH

Accession

Primary (citable) accession number: Q44856

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2003
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)