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Q44776 (MRAY_BORBU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:BB_0303
OrganismBorrelia burgdorferi (Lyme disease spirochete)
Taxonomic identifier139 [NCBI]
Taxonomic lineageBacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 351351Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_0000108790

Regions

Transmembrane17 – 3721Helical; Potential
Transmembrane62 – 8221Helical; Potential
Transmembrane85 – 10521Helical; Potential
Transmembrane130 – 15021Helical; Potential
Transmembrane158 – 17821Helical; Potential
Transmembrane190 – 21021Helical; Potential
Transmembrane230 – 25021Helical; Potential
Transmembrane254 – 27421Helical; Potential
Transmembrane279 – 29921Helical; Potential
Transmembrane328 – 34821Helical; Potential

Experimental info

Sequence conflict911L → C in CAA65460. Ref.3
Sequence conflict911L → C in CAA65292. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q44776 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: F6FE800C0C6151E3

FASTA35139,480
        10         20         30         40         50         60 
MFYLLGLRLL KYITFRMAYA TIFAFLLSLI VGPYIILKLK KLRADQILRE DGPKRHLSEK 

        70         80         90        100        110        120 
AGIPTMGGIL IFFCVFISLV FWSNILNVYF LIMVFVMLGF AFLGFIDDFL KIKKKTSDGL 

       130        140        150        160        170        180 
KARFKIYGQI IFSFFSVGIL YYFGGEHVSV IYFPFIKSFQ IDLGLFYIPF GMFILISASN 

       190        200        210        220        230        240 
SFNLTDGLDG LAIGLSIVIT GALIIIAYLT SRADFAAYLH IPNIKGSEEL VIFLGALLGG 

       250        260        270        280        290        300 
SFGFLWFNAY PAKIMMGDTG SLALGAILGM AALILKSEIL FSILAGVFII ETMSVIIQVL 

       310        320        330        340        350 
VYKKTKKRVF KMAPLHHHFE ELGWSEMQVV IRFWIIGLIF AIIALSTIKI R

« Hide

References

« Hide 'large scale' references
[1]Dunn J.J., Butler-Loffredo L., Kieleczawa J., Medalle J., Luft B.J.
Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
[2]"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi."
Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. expand/collapse author list , Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B., Smith H.O., Venter J.C.
Nature 390:580-586(1997) [PubMed: 9403685] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
[3]"Mapping and sequencing of a locus involved in the cell division of Borrelia burgdorferi."
Ge Y., Old I.G., Saint-Girons I., Charon N.W.
Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 49-351.
Strain: 212.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U43739 Genomic DNA. Translation: AAA85626.1.
AE000783 Genomic DNA. Translation: AAC66645.1.
X96685 Genomic DNA. Translation: CAA65460.1.
X96432 Genomic DNA. Translation: CAA65292.1.
PIRG70137.
RefSeqNP_212437.1. NC_001318.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBORT00000008432; EBBORP00000007762; EBBORG00000008431.
GeneID1195140.
GenomeReviewsGene locus BB_0303 in contig AE000783_GR.
KEGGbbu:BB0303.
NMPDRfig|224326.1.peg.687.
PATRIC20557224. VBIBorBur75917_0702.
TIGRBB_0303.

Phylogenomic databases

GeneTreeEBGT00050000007216.
HOGENOMHBG708263.
OMAQVGYFKW.
PhylomeDBQ44776.
ProtClustDBPRK00108.

Enzyme and pathway databases

BioCycBBUR224326:BB_0303-MONOMER.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_BORBU
AccessionPrimary (citable) accession number: Q44776
Secondary accession number(s): Q60120
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: January 25, 2012
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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