ID   TRPE_BUCDN              Reviewed;         519 AA.
AC   Q44697;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JUN-2009, entry version 55.
DE   RecName: Full=Anthranilate synthase component 1;
DE            EC=4.1.3.27;
DE   AltName: Full=Anthranilate synthase component I;
GN   Name=trpE;
OS   Buchnera aphidicola subsp. Diuraphis noxia.
OG   Plasmid pBDn.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Buchnera.
OX   NCBI_TaxID=118101;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=96156780; PubMed=8593038;
RA   Lai C.-Y., Baumann P., Moran N.;
RT   "The endosymbiont (Buchnera sp.) of the aphid Diuraphis noxia contains
RT   plasmids consisting of trpEG and tandem repeats of trpEG
RT   pseudogenes.";
RL   Appl. Environ. Microbiol. 62:332-339(1996).
CC   -!- CATALYTIC ACTIVITY: Chorismate + L-glutamine = anthranilate +
CC       pyruvate + L-glutamate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 1/5.
CC   -!- SUBUNIT: Tetramer of two components I and two components II (By
CC       similarity).
CC   -!- MISCELLANEOUS: Component I catalyzes the formation of anthranilate
CC       using ammonia rather than glutamine, whereas component II provides
CC       glutamine amidotransferase activity.
CC   -!- SIMILARITY: Belongs to the anthranilate synthase component I
CC       family.
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DR   EMBL; L46769; AAB02275.1; -; Genomic_DNA.
DR   HSSP; P00897; 1I7S.
DR   GO; GO:0004049; F:anthranilate synthase activity; IEA:EC.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005801; ADC_synthase.
DR   InterPro; IPR006805; Anth_synth_I_N.
DR   InterPro; IPR019999; Anthranilate_synth_I_C.
DR   InterPro; IPR015890; Chorismate-bd_C.
DR   InterPro; IPR005257; TrpE_synth.
DR   Gene3D; G3DSA:3.60.120.10; TRPE_1_chor_bd; 1.
DR   PANTHER; PTHR11236; TRPE_1_chor_bd; 1.
DR   Pfam; PF04715; Anth_synt_I_N; 1.
DR   Pfam; PF00425; Chorismate_bind; 1.
DR   PRINTS; PR00095; ANTSNTHASEI.
DR   ProDom; PD000779; Anth_synth_chor; 1.
DR   TIGRFAMs; TIGR00565; trpE_proteo; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Lyase;
KW   Plasmid; Tryptophan biosynthesis.
FT   CHAIN         1    519       Anthranilate synthase component 1.
FT                                /FTId=PRO_0000154083.
SQ   SEQUENCE   519 AA;  59521 MW;  C04B205AD8D74ECB CRC64;
     MEKKPYEIKI IQKKAKYHPD PTIVFNHICG SQKQTLLLET AEINKKNDLE SIMIIDAALR
     ISSERNHSVQ LTALSKNGEN ILSILKSNLK QKVQMFIQDT SIRLEFPHFQ KNLDEDKKIF
     SLSIFDTFRF IMKFFKNRNK VQKAMFFGGL FSYDLISNFE LLPKLKKTQK CPHFCFYLAE
     TLLIVDHQKK TCLIQNSLFT KNSHEQMRVE KRGREIQKKL EASLNSIPVR QEVKNSMLTA
     NMSDEQYCSI IKKLQILIRK GEIFQVVPSR KFFLPCSNPL SAYQKLKKSN PSPYMFFMQD
     KDFTLFGASP ESSLKYDDTT RQVELYPIAG TRPRGRNMDG TLNLDLDSRI ELEMRTNHKE
     LAEHLMLVDL ARNDLARICE PGSRYVSDLV RVDKYPHVMH LVSRVVGTLK PELDALHAYA
     ACMNMGTLTG APKIRAMELI AEYEMEQRGS YGGAIGYFTD LGNLDTCITI RSAYVEDNIA
     TIQSGSGIVY NSIPEDEVKE GINKAKRVIN AIQHAHHLV
//