Reviewed, UniProtKB/Swiss-Prot Q44697 (TRPE_BUCDN)

Names and origin

Protein names

Recommended name:
    Anthranilate synthase component 1
    EC=4.1.3.27
Alternative name(s):
    Anthranilate synthase component I

Gene names

Name:

trpE

Encoded on

Plasmid pBDn

Organism

Buchnera aphidicola subsp. Diuraphis noxia

Taxonomic identifier

118101 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	519 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Technical term	Plasmid
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 519	519	Anthranilate synthase component 1		PRO_0000154083

Sequences

	Sequence		Length	Mass (Da)
	Q44697-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: C04B205AD8D74ECB	FASTA	519	59,521
	10 20 30 40 50 60 MEKKPYEIKI IQKKAKYHPD PTIVFNHICG SQKQTLLLET AEINKKNDLE SIMIIDAALR 70 80 90 100 110 120 ISSERNHSVQ LTALSKNGEN ILSILKSNLK QKVQMFIQDT SIRLEFPHFQ KNLDEDKKIF 130 140 150 160 170 180 SLSIFDTFRF IMKFFKNRNK VQKAMFFGGL FSYDLISNFE LLPKLKKTQK CPHFCFYLAE 190 200 210 220 230 240 TLLIVDHQKK TCLIQNSLFT KNSHEQMRVE KRGREIQKKL EASLNSIPVR QEVKNSMLTA 250 260 270 280 290 300 NMSDEQYCSI IKKLQILIRK GEIFQVVPSR KFFLPCSNPL SAYQKLKKSN PSPYMFFMQD 310 320 330 340 350 360 KDFTLFGASP ESSLKYDDTT RQVELYPIAG TRPRGRNMDG TLNLDLDSRI ELEMRTNHKE 370 380 390 400 410 420 LAEHLMLVDL ARNDLARICE PGSRYVSDLV RVDKYPHVMH LVSRVVGTLK PELDALHAYA 430 440 450 460 470 480 ACMNMGTLTG APKIRAMELI AEYEMEQRGS YGGAIGYFTD LGNLDTCITI RSAYVEDNIA 490 500 510 TIQSGSGIVY NSIPEDEVKE GINKAKRVIN AIQHAHHLV

References

[1]	"The endosymbiont (Buchnera sp.) of the aphid Diuraphis noxia contains plasmids consisting of trpEG and tandem repeats of trpEG pseudogenes." Lai C.-Y., Baumann P., Moran N. Appl. Environ. Microbiol. 62:332-339(1996) [PubMed: 8593038] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	L46769 Genomic DNA. Translation: AAB02275.1.
3D structure databases
SMR	Q44697. Positions 7-517.
ModBase	Search...
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR006805. Anth_synth_I_N. IPR019999. Anthranilate_synth_I_C. IPR015890. Chorismate-bd_C. IPR005257. TrpE_synth. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
PANTHER	PTHR11236. TRPE_1_chor_bd. 1 hit.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
TIGRFAMs	TIGR00565. trpE_proteo. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE_BUCDN

Accession

Primary (citable) accession number: Q44697

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	February 9, 2010
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)