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Q44696 (TRPG_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Anthranilate synthase component 2
EC=4.1.3.27
Alternative name(s):
Anthranilate synthase component II
Glutamine amido-transferase
Gene names
Name:trpG
Ordered Locus Names:BUpT02
AND
Name:trpG2
Ordered Locus Names:BUpT04
Encoded onPlasmid pTrp (pBAp)
OrganismBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifier107806 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length200 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Catalytic activity

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.

Subunit structure

Tetramer of two components I and two components II.

Miscellaneous

Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.

Sequence similarities

Contains 1 glutamine amidotransferase type-1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 200200Anthranilate synthase component 2
PRO_0000056872

Regions

Domain3 – 196194Glutamine amidotransferase type-1

Sites

Active site841 By similarity
Active site1701 By similarity
Active site1721 By similarity

Experimental info

Sequence conflict691D → N in AAD09347. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q44696 [UniParc].

Last modified December 1, 2000. Version 2.
Checksum: FF16C661D5887B04

FASTA20022,569
        10         20         30         40         50         60 
MANILLLDNI DSFTYNLVEQ LRNQKNNVLV YRNTVSIDII FNSLKKLTHP ILMLSPGPSL 

        70         80         90        100        110        120 
PKHAGCMLDL IKKVKGDIPI VGICLGHQAI VEAYGGIIGY AGEIFHGKAS LIRHDGLEMF 

       130        140        150        160        170        180 
EGVPQPLPVA RYHSLICNKI PEKFVINSYF EKMIMSVRNN CDRVCGFQFH PESILTTHGD 

       190        200 
QILEKIIHWA SLKYITNKKQ

« Hide

References

« Hide 'large scale' references
[1]"The tryptophan biosynthetic pathway of aphid endosymbionts (Buchnera): genetics and evolution of plasmid-associated anthranilate synthase (trpEG) within the aphididae."
Rouhbakhsh D., Lai C.-Y., von Dohlen C.D., Clark M.A., Baumann L., Baumann P., Moran N.A., Voegtlin D.J.
J. Mol. Evol. 42:414-421(1996) [PubMed: 8642610] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
Nature 407:81-86(2000) [PubMed: 10993077] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: APS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L43555 Genomic DNA. Translation: AAD09347.1.
AP001070 Genomic DNA. Translation: BAA95418.1.
AP001070 Genomic DNA. Translation: BAA95419.1.
RefSeqNP_057963.1. NC_002252.1.
NP_057964.1. NC_002252.1.

3D structure databases

ProteinModelPortalQ44696.
SMRQ44696. Positions 2-193.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBUCT00000002759; EBBUCP00000002535; EBBUCG00000002759.
EBBUCT00000002760; EBBUCP00000002536; EBBUCG00000002760.
GeneID1109446.
1109447.
GenomeReviewsGene locus BUpT02 in contig AP001070_GR.
Gene locus BUpT04 in contig AP001070_GR.
KEGGbuc:BUpT02.
buc:BUpT04.
PATRIC21243480. VBIBucAph127364_0002.

Phylogenomic databases

GeneTreeEBGT00050000008118.
HOGENOMHBG292341.
OMAYGGKVER.
ProtClustDBPRK05670.

Enzyme and pathway databases

BioCycBSP107806:BUPT02-MONOMER.
BSP107806:BUPT04-MONOMER.

Family and domain databases

InterProIPR017926. GATASE_1.
IPR006221. TrpG_papA.
[Graphical view]
KOK01658.
PfamPF00117. GATase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00566. TrpG_papA. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRPG_BUCAI
AccessionPrimary (citable) accession number: Q44696
Secondary accession number(s): Q9K2G8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 1, 2000
Last modified: January 25, 2012
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Buchnera aphidicola (subsp. Acyrthosiphon pisum)

Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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