ID   TRPE_BUCRP              Reviewed;         514 AA.
AC   Q44691;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JUN-2009, entry version 56.
DE   RecName: Full=Anthranilate synthase component 1;
DE            EC=4.1.3.27;
DE   AltName: Full=Anthranilate synthase component I;
GN   Name=trpE;
OS   Buchnera aphidicola subsp. Rhopalosiphum padi.
OG   Plasmid pBRp.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Buchnera.
OX   NCBI_TaxID=98793;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=96215866; PubMed=8642610;
RA   Rouhbakhsh D., Lai C.-Y., von Dohlen C.D., Clark M.A., Baumann L.,
RA   Baumann P., Moran N.A., Voegtlin D.J.;
RT   "The tryptophan biosynthetic pathway of aphid endosymbionts
RT   (Buchnera): genetics and evolution of plasmid-associated anthranilate
RT   synthase (trpEG) within the aphididae.";
RL   J. Mol. Evol. 42:414-421(1996).
CC   -!- CATALYTIC ACTIVITY: Chorismate + L-glutamine = anthranilate +
CC       pyruvate + L-glutamate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 1/5.
CC   -!- SUBUNIT: Tetramer of two components I and two components II (By
CC       similarity).
CC   -!- MISCELLANEOUS: Component I catalyzes the formation of anthranilate
CC       using ammonia rather than glutamine, whereas component II provides
CC       glutamine amidotransferase activity.
CC   -!- SIMILARITY: Belongs to the anthranilate synthase component I
CC       family.
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DR   EMBL; L43551; AAB05986.1; -; Genomic_DNA.
DR   HSSP; P00897; 1I7S.
DR   GO; GO:0004049; F:anthranilate synthase activity; IEA:EC.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005801; ADC_synthase.
DR   InterPro; IPR006805; Anth_synth_I_N.
DR   InterPro; IPR019999; Anthranilate_synth_I_C.
DR   InterPro; IPR015890; Chorismate-bd_C.
DR   InterPro; IPR005257; TrpE_synth.
DR   Gene3D; G3DSA:3.60.120.10; TRPE_1_chor_bd; 1.
DR   PANTHER; PTHR11236; TRPE_1_chor_bd; 1.
DR   Pfam; PF04715; Anth_synt_I_N; 1.
DR   Pfam; PF00425; Chorismate_bind; 1.
DR   PRINTS; PR00095; ANTSNTHASEI.
DR   ProDom; PD000779; Anth_synth_chor; 1.
DR   TIGRFAMs; TIGR00565; trpE_proteo; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Lyase;
KW   Plasmid; Tryptophan biosynthesis.
FT   CHAIN         1    514       Anthranilate synthase component 1.
FT                                /FTId=PRO_0000154086.
SQ   SEQUENCE   514 AA;  58985 MW;  3B35BCF38DB434B9 CRC64;
     MKKSAYPIEI IQKQAPYHPD PTMIFNHLCE SRSETLLLET ADNKKKRSRK IMIIDSAMRI
     SSEHNAVKLT PLSINGMEIL LVLKKIISKK IEIYRRKKNT ILIFPNIEKD LDEDKKLFSL
     SVFDAFRLII KTFENREKKS KAMFFGGLFS YDLISVFETL PKLKGNQKCS NFCFYLAETL
     LVLDHQQKTC LIQSSLFTKN SNEKKRIEER SVEIKQKLNQ KLNSIPKIKI KDINLTSNMN
     NFEYGSIIKK LQKLIQKGEI FQVVPSRKFY LPCPNPLSAY QKLKKSNPSP YMFFMQDQDF
     TLFGASPESS LKYDEKTRKI ELYPIAGTRP RGRTKDGNLD LDLDSRIELE MRTNHKELAE
     HLMLVDLARN DLARICKPGS RYVSDLVRVD RYSHVMHLVS RVIGELREGL DALHAYASCM
     NMGTLTGAPK VCAMQLIAEY EKEKRGSYGG AIGYFTDLGN LDTCITIRSA YVEKRYCYNQ
     AGAGIVYNSI PEDEVNESLN KAQAVINAIK NAHY
//