Q44691 (TRPE_BUCRP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anthranilate synthase component 1
EC=4.1.3.27

Alternative name(s):
Anthranilate synthase component I

Gene names

Name:

trpE

Encoded on

Plasmid pBRp

Organism

Buchnera aphidicola subsp. Rhopalosiphum padi

Taxonomic identifier

98793 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	514 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Technical term	Plasmid
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 514	514	Anthranilate synthase component 1		PRO_0000154086

Sequences

	Sequence		Length	Mass (Da)
	Q44691 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 3B35BCF38DB434B9	FASTA	514	58,985
	10 20 30 40 50 60 MKKSAYPIEI IQKQAPYHPD PTMIFNHLCE SRSETLLLET ADNKKKRSRK IMIIDSAMRI 70 80 90 100 110 120 SSEHNAVKLT PLSINGMEIL LVLKKIISKK IEIYRRKKNT ILIFPNIEKD LDEDKKLFSL 130 140 150 160 170 180 SVFDAFRLII KTFENREKKS KAMFFGGLFS YDLISVFETL PKLKGNQKCS NFCFYLAETL 190 200 210 220 230 240 LVLDHQQKTC LIQSSLFTKN SNEKKRIEER SVEIKQKLNQ KLNSIPKIKI KDINLTSNMN 250 260 270 280 290 300 NFEYGSIIKK LQKLIQKGEI FQVVPSRKFY LPCPNPLSAY QKLKKSNPSP YMFFMQDQDF 310 320 330 340 350 360 TLFGASPESS LKYDEKTRKI ELYPIAGTRP RGRTKDGNLD LDLDSRIELE MRTNHKELAE 370 380 390 400 410 420 HLMLVDLARN DLARICKPGS RYVSDLVRVD RYSHVMHLVS RVIGELREGL DALHAYASCM 430 440 450 460 470 480 NMGTLTGAPK VCAMQLIAEY EKEKRGSYGG AIGYFTDLGN LDTCITIRSA YVEKRYCYNQ 490 500 510 AGAGIVYNSI PEDEVNESLN KAQAVINAIK NAHY

References

[1]	"The tryptophan biosynthetic pathway of aphid endosymbionts (Buchnera): genetics and evolution of plasmid-associated anthranilate synthase (trpEG) within the aphididae." Rouhbakhsh D., Lai C.-Y., von Dohlen C.D., Clark M.A., Baumann L., Baumann P., Moran N.A., Voegtlin D.J. J. Mol. Evol. 42:414-421(1996) [PubMed: 8642610] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L43551 Genomic DNA. Translation: AAB05986.1.
3D structure databases
ProteinModelPortal	Q44691.
SMR	Q44691. Positions 7-513.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR019999. Anth_synth_I. IPR006805. Anth_synth_I_N. IPR005257. Anth_synth_I_TrpE. IPR015890. Chorismate-bd_C. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
SUPFAM	SSF56322. TRPE_1_chor_bd. 1 hit.
TIGRFAMs	TIGR00565. TrpE_proteo. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE_BUCRP

Accession

Primary (citable) accession number: Q44691

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	May 31, 2011
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program