Reviewed, UniProtKB/Swiss-Prot Q44689 (TRPE_BUCRM)

Names and origin

Protein names

Recommended name:
    Anthranilate synthase component 1
    EC=4.1.3.27
Alternative name(s):
    Anthranilate synthase component I

Gene names

Name:

trpE

Encoded on

Plasmid pBRm

Organism

Buchnera aphidicola subsp. Rhopalosiphum maidis

Taxonomic identifier

118109 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	514 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Technical term	Plasmid
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 514	514	Anthranilate synthase component 1		PRO_0000154085

Sequences

	Sequence		Length	Mass (Da)
	Q44689-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 1E6E38FBA0F7FB6F	FASTA	514	58,772
	10 20 30 40 50 60 MKKKPYQIEI IQKKAPYHPD PTMIFNHLCE SRSATLLLET AEVNKKKDLE SIMIIDSAIR 70 80 90 100 110 120 ISSKKNLVKL KPLSINGEEI LLALKKRIPK KIEIYEKNKN IILVFPKIEK NLDEDKKLFS 130 140 150 160 170 180 LSVFDAFRFM IKIFENKEKK SKAMFFGGLF SYDLSQFFES LPKLKGNQKC SNFCFYLAET 190 200 210 220 230 240 LLVLDHQKKT CLIQNSLFTK NANEKKRIKE RSIEIEKKLN EKLKSIPKVK ITDINLTSNM 250 260 270 280 290 300 NNFEYGSIIK KLQKLIQKGE IFQVVPSRKF YLPCPNPLSA YQKLKKSNPS PYMFFMQDKD 310 320 330 340 350 360 FTLFGASPES SLKYDEKTRK IELYPIAGTR PRGRTEDGNL DLDLDSRIEL EMRTNHKELA 370 380 390 400 410 420 EHLMLVDLAR NDLARICKPG SRYVSDLVKV DKYSHVMHLV SKVIGELKEG LDALHAYASC 430 440 450 460 470 480 MNMGTLTGAP KVRAMQLIAE YEKEKRGSYG GAIGYFTDLG NLDTCITIRS AYVENIATIQ 490 500 510 AGAGIVYNSI PEDEVNESLN KAQAVINAIK NAHY

References

[1]

"The tryptophan biosynthetic pathway of aphid endosymbionts (Buchnera): genetics and evolution of plasmid-associated anthranilate synthase (trpEG) within the aphididae." Rouhbakhsh D., Lai C.-Y., von Dohlen C.D., Clark M.A., Baumann L., Baumann P., Moran N.A., Voegtlin D.J. J. Mol. Evol. 42:414-421(1996) [PubMed: 8642610] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	L43550 Genomic DNA. Translation: AAB05974.1.
3D structure databases
HSSP	HSSP built from PDB template 1I1Q based on UniProtKB P00898.
ModBase	Search...
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR006805. Anth_synth_I_N. IPR019999. Anthranilate_synth_I_C. IPR015890. Chorismate-bd_C. IPR005257. TrpE_synth. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
PANTHER	PTHR11236. TRPE_1_chor_bd. 1 hit.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
ProDom	PD000779. Anth_synth_chor. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00565. trpE_proteo. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE_BUCRM

Accession

Primary (citable) accession number: Q44689

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)