Reviewed, UniProtKB/Swiss-Prot Q44679 (PUR6_CORAM)

Names and origin

Protein names

Recommended name:
    Phosphoribosylaminoimidazole carboxylase catalytic subunit
    EC=4.1.1.21
Alternative name(s):
    AIR carboxylase
      Short name=AIRC

Gene names

Name:

purE

Organism

Corynebacterium ammoniagenes (Brevibacterium ammoniagenes)

Taxonomic identifier

1697 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	177 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This subunit can alone transform AIR to CAIR, but in association with purK, which possesses an ATPase activity, an enzyme complex is produced which is capable of converting AIR to CAIR efficiently under physiological condition By similarity.
Catalytic activity	5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2.
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.
Subunit structure	Homooctamer By similarity.
Sequence similarities	Belongs to the AIR carboxylase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Molecular function	Decarboxylase Lyase
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	phosphoribosylaminoimidazole carboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 177	177	Phosphoribosylaminoimidazole carboxylase catalytic subunit		PRO_0000074972
Sites
	Binding site	12	1	Substrate By similarity
	Binding site	15	1	Substrate By similarity
	Binding site	42	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q44679-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: EAFA45863C7265BB	FASTA	177	18,741
	10 20 30 40 50 60 MTAPLVGLIM GSDSDWPTVE PAAEVLDEFG VPFEVGVVSA HRTPEKMLDY AKQAHTRGIK 70 80 90 100 110 120 VIVACAGGAA HLPGMVAAAT PLPVIGIPRA LKDLEGLDSL LSIVQMPAGV PVATVSIGGA 130 140 150 160 170 KNAGLLAIRT LGVQYSELVE RMADYQENMA DYQPKIWPRK LSKKTPIFAP SSWGTRP

References

[1]

"Genomic organization of purK and purE in Brevibacterium ammoniagenes ATCC 6872: purE locus provides a clue for genomic evolution." Chung S.O., Lee J.H., Lee S.Y., Lee D.S. FEMS Microbiol. Lett. 137:265-268(1996) [PubMed: 8998996] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 6872 / DSM 20305 / KCTC 1019 / NCTC 2399.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X91189 Genomic DNA. Translation: CAA62599.1.
3D structure databases
SMR	Q44679. Positions 4-149.
ModBase	Search...
Enzyme and pathway databases
BRENDA	4.1.1.21. 259964.
Family and domain databases
InterPro	IPR000031. AIR_COase_core. [Graphical view]
Gene3D	G3DSA:3.40.50.7700. AIR_carboxyl. 1 hit.
PANTHER	PTHR23046. AIR_carboxyl. 1 hit.
Pfam	PF00731. AIRC. 1 hit. [Graphical view]
TIGRFAMs	TIGR01162. purE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR6_CORAM

Accession

Primary (citable) accession number: Q44679

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	February 9, 2010
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)