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Q44674 (BLAC_BACAM) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase

EC=3.5.2.6
Alternative name(s):
Penicillinase
Gene names
Name:penP
OrganismBacillus amyloliquefaciens (Bacillus velezensis)
Taxonomic identifier1390 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein is a beta-lactamase with a substrate specificity for penicillins.

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Sequence similarities

Belongs to the class-A beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   DomainSignal
   Molecular functionHydrolase
Gene Ontology (GO)
   Biological_processbeta-lactam antibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434 By similarity
Chain35 – 306272Beta-lactamase
PRO_0000016969

Regions

Region251 – 2533Substrate binding By similarity

Sites

Active site891Acyl-ester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q44674 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: BEC57A283995E415

FASTA30633,409
        10         20         30         40         50         60 
MNVKRKATLK FGICIGLLCV SFTGFNSLFG STHAEAKSIE NTKMTSCITN QKFVQLEKKF 

        70         80         90        100        110        120 
DARLGVYAID TGSNKTIAYR PNERFAYAST YKVLAAAAVL KQKPIEKLND VIRYTKEDLV 

       130        140        150        160        170        180 
TYSPITEKHL DTGMSLKEIS EAAIRYSDNT AGNILLQQLG GPKGFEKSLK QIGDHVTKAD 

       190        200        210        220        230        240 
RFETDLNSAI PGDIRDTSTA KALATDLKAF TLGNTLTTDK RTILTDWMRG NATGDELIRA 

       250        260        270        280        290        300 
GAPAGWEVGD KSGAGSYGTR NDIAIVWPPD RAPIVLAILT KRFTKDAEYD NALIAEAAKV 


ALDDLK 

« Hide

References

[1]"Identification of penicillinase-encoding genes of Bacillus amyloliquefaciens and Bacillus subtilis."
van Dijl J.M., de Jong A., Nauta A., Venema G., Bron S.
Submitted (AUG-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z35653 Genomic DNA. Translation: CAA84712.1.
PIRS47330.

3D structure databases

ProteinModelPortalQ44674.
SMRQ44674. Positions 53-305.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS11.A01.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSPR00118. BLACTAMASEA.
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBLAC_BACAM
AccessionPrimary (citable) accession number: Q44674
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: October 16, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families