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Q44674

- BLAC_BACAM

UniProt

Q44674 - BLAC_BACAM

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Protein

Beta-lactamase

Gene

penP

Organism
Bacillus amyloliquefaciens (Bacillus velezensis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

This protein is a beta-lactamase with a substrate specificity for penicillins.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Acyl-ester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. beta-lactam antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Protein family/group databases

MEROPSiS11.A01.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase (EC:3.5.2.6)
Alternative name(s):
Penicillinase
Gene namesi
Name:penP
OrganismiBacillus amyloliquefaciens (Bacillus velezensis)
Taxonomic identifieri1390 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434By similarityAdd
BLAST
Chaini35 – 306272Beta-lactamasePRO_0000016969Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ44674.
SMRiQ44674. Positions 53-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni251 – 2533Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q44674-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNVKRKATLK FGICIGLLCV SFTGFNSLFG STHAEAKSIE NTKMTSCITN
60 70 80 90 100
QKFVQLEKKF DARLGVYAID TGSNKTIAYR PNERFAYAST YKVLAAAAVL
110 120 130 140 150
KQKPIEKLND VIRYTKEDLV TYSPITEKHL DTGMSLKEIS EAAIRYSDNT
160 170 180 190 200
AGNILLQQLG GPKGFEKSLK QIGDHVTKAD RFETDLNSAI PGDIRDTSTA
210 220 230 240 250
KALATDLKAF TLGNTLTTDK RTILTDWMRG NATGDELIRA GAPAGWEVGD
260 270 280 290 300
KSGAGSYGTR NDIAIVWPPD RAPIVLAILT KRFTKDAEYD NALIAEAAKV

ALDDLK
Length:306
Mass (Da):33,409
Last modified:November 1, 1996 - v1
Checksum:iBEC57A283995E415
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35653 Genomic DNA. Translation: CAA84712.1.
PIRiS47330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35653 Genomic DNA. Translation: CAA84712.1 .
PIRi S47330.

3D structure databases

ProteinModelPortali Q44674.
SMRi Q44674. Positions 53-305.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S11.A01.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view ]
PRINTSi PR00118. BLACTAMASEA.
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of penicillinase-encoding genes of Bacillus amyloliquefaciens and Bacillus subtilis."
    van Dijl J.M., de Jong A., Nauta A., Venema G., Bron S.
    Submitted (AUG-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiBLAC_BACAM
AccessioniPrimary (citable) accession number: Q44674
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3