Reviewed, UniProtKB/Swiss-Prot Q44620 (OMP2A_BRUAB)

Names and origin

Protein names

Recommended name:
    Porin omp2a

Gene names

Name:	omp2a
Ordered Locus Names:	BruAb1_0655

Organism

Brucella abortus [Complete proteome] [HAMAP]

Taxonomic identifier

235 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane. Ref.2
Subunit structure	Monomer By similarity.
Subcellular location	Cell outer membrane; Multi-pass membrane protein.
Domain	Consists of 16-stranded beta-barrel sheets, with large surface-exposed loops, that form a transmembrane pore at the center of each barrel. The pore is partially ocluded by a peptide loop that folds into the pore lumen By similarity.
Miscellaneous	The pore formed by omp2a is larger than the one formed by omp2b. omp2b pores have optimal permeability to allow growth and protection against harmful compounds. The larger pore formed by omp2a may be advantageous for intracellular growth, when the bacterium is competing with the host cell for nutrients whose concentration is particularly low within the phagosome.
Sequence similarities	Belongs to the alphaproteobacteria porin family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell membrane Cell outer membrane Membrane
Domain	Signal Transmembrane
Molecular function	Porin
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cell outer membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW pore complex Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 321	299	Porin omp2a		PRO_5000143210
Natural variations
	Natural variant	139	1	S → STGTDLQFAYITLGGFKVGI DESEFHTFTGYLGDVINDDV VAAGSYR in strain: biovar 5.

Sequences

	Sequence		Length	Mass (Da)
	Q44620-1 [UniParc]. Last modified November 25, 2008. Version 2. Checksum: 255D624AB464A4A7	FASTA	321	34,535
	10 20 30 40 50 60 MNIKSLLLGS AAALVAASGA QAADAIVAPE PEAVEYVRVC DAYGAGYFYI PGTETCLRVH 70 80 90 100 110 120 GYVRYDVKGG DDVYSGTDRN GWDKGARFAL MFNTNSETEL GTLGTYTQLR FNYTSNNSRH 130 140 150 160 170 180 DGQYGDFSDD RDVADGGVST GKIAYTFTGG NGFSAVIALE QGGEDVDNDY TIDGYMPHVV 190 200 210 220 230 240 GGLKYAGGWG SIAGVVAYDS VIEEWATKVR GDVNITDRFS VWLQGAYSSA ATPNQNYGQW 250 260 270 280 290 300 GGDWAVWGGA KFIAPEKATF NLQAAHDDWG KTAVTANVAY QLVPGFTITP EVSYTKFGGE 310 320 WKDTVAEDNA WGGIVRFQRS F

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Species-specific sequences at the omp2 locus of Brucella type strains." Ficht T.A., Husseinen H.S., Derr J., Bearden S.W. Int. J. Syst. Bacteriol. 46:329-331(1996) [PubMed: 8573514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: biovar 5.
[2]	"Molecular, antigenic, and functional analyses of Omp2b porin size variants of Brucella spp." Paquet J.-Y., Diaz M.A., Genevrois S., Grayon M., Verger J.-M., de Bolle X., Lakey J.H., Letesson J.-J., Cloeckaert A. J. Bacteriol. 183:4839-4847(2001) [PubMed: 11466287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION IN PERMEABILITY TO SUGAR. Strain: 45/20.
[3]	"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis." Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C. J. Bacteriol. 187:2715-2726(2005) [PubMed: 15805518] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 9-941 / Biovar 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U26438 Genomic DNA. Translation: AAA67783.1. AY008719 Genomic DNA. Translation: AAG38243.1. AE017223 Genomic DNA. Translation: AAX74030.1.
PIR	B37050.
RefSeq	YP_221391.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3339453.
GenomeReviews	Gene locus BruAb1_0655 in contig AE017223_GR.
KEGG	bmb:BruAb1_0655.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	LQFAYIT
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

OMP2A_BRUAB

Accession

Primary (citable) accession number: Q44620
Secondary accession number(s): Q44667, Q57EA4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2008
Last sequence update:	November 25, 2008
Last modified:	November 24, 2009
This is version 37 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)