ID   AROE_BUCAI              Reviewed;         273 AA.
AC   Q44607;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 3.
DT   16-JUN-2009, entry version 61.
DE   RecName: Full=Shikimate dehydrogenase;
DE            EC=1.1.1.25;
GN   Name=aroE; OrderedLocusNames=BU493;
OS   Buchnera aphidicola subsp. Acyrthosiphon pisum (Acyrthosiphon pisum
OS   symbiotic bacterium).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Buchnera.
OX   NCBI_TaxID=118099;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tokyo 1998;
RX   MEDLINE=20445173; PubMed=10993077; DOI=10.1038/35024074;
RA   Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.;
RT   "Genome sequence of the endocellular bacterial symbiont of aphids
RT   Buchnera sp. APS.";
RL   Nature 407:81-86(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 253-273.
RX   MEDLINE=95212914; PubMed=7535281; DOI=10.1016/0378-1119(94)00910-K;
RA   Rouhbakhsh D., Baumann P.;
RT   "Characterization of a putative 23S-5S rRNA operon of Buchnera
RT   aphidicola (endosymbiont of aphids) unlinked to the 16S rRNA-encoding
RT   gene.";
RL   Gene 155:107-112(1995).
CC   -!- CATALYTIC ACTIVITY: Shikimate + NADP(+) = 3-dehydroshikimate +
CC       NADPH.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 4/7.
CC   -!- SIMILARITY: Belongs to the shikimate dehydrogenase family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA79125.1; Type=Frameshift; Positions=265;
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DR   EMBL; BA000003; BAB13186.1; -; Genomic_DNA.
DR   EMBL; U10496; AAA79125.1; ALT_FRAME; Genomic_DNA.
DR   PIR; I40062; I40062.
DR   RefSeq; NP_240300.1; -.
DR   HSSP; P15770; 1NYT.
DR   GeneID; 1109836; -.
DR   GenomeReviews; BA000003_GR; BU493.
DR   KEGG; buc:BU493; -.
DR   HOGENOM; Q44607; -.
DR   OMA; Q44607; YDMMYGR.
DR   BioCyc; BSP107806:BU493-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0004764; F:shikimate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00222; -; 1.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR011342; Quinate/shikimate_5-DH.
DR   InterPro; IPR013708; Shikimate_DH-bd_N.
DR   InterPro; IPR006151; Shikm_DH/Glu-tRNA_Rdtase.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF01488; Shikimate_DH; 1.
DR   Pfam; PF08501; Shikimate_dh_N; 1.
DR   TIGRFAMs; TIGR00507; aroE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    273       Shikimate dehydrogenase.
FT                                /FTId=PRO_0000135995.
FT   NP_BIND     131    135       NADP (By similarity).
FT   ACT_SITE     70     70       Proton acceptor (Potential).
SQ   SEQUENCE   273 AA;  31002 MW;  4EAA9019E77213F9 CRC64;
     MFKCKNFNYA VFGNPINHSK SPEIHSLFSK QTGISHFYKS CNVPLNSLYA VLQDFFKKDG
     RGANITAPFK QEAYFFCNKL TKRAEVAQSV NTLKKIDNCN ILGDNTDGIG LLSDLIRLNF
     IKKNYSILII GAGGAARGVL FPLLSYGCSI CIFNRTVLNA EKLVLQFHKY GNINVFNTNS
     LHVKSFDLII NATSHFIQDK DNFIPFSCVS SKTCFYDMNY QTDNTFFFDW SRKTGSNFFS
     NGIGMLVFQA AHSFFLWHNV LPEIDYIIDL LNK
//