ID   TRPE_BUCSC              Reviewed;         530 AA.
AC   Q44598;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JUN-2009, entry version 56.
DE   RecName: Full=Anthranilate synthase component 1;
DE            EC=4.1.3.27;
DE   AltName: Full=Anthranilate synthase component I;
GN   Name=trpE;
OS   Buchnera aphidicola subsp. Schlechtendalia chinensis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Buchnera.
OX   NCBI_TaxID=118110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=95261545; PubMed=7742976;
RX   DOI=10.1111/j.1365-2583.1995.tb00007.x;
RA   Lai C.-Y., Baumann P., Moran N.A.;
RT   "Genetics of the tryptophan biosynthetic pathway of the prokaryotic
RT   endosymbiont (Buchnera) of the aphid Schlechtendalia chinensis.";
RL   Insect Mol. Biol. 4:47-59(1995).
CC   -!- CATALYTIC ACTIVITY: Chorismate + L-glutamine = anthranilate +
CC       pyruvate + L-glutamate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 1/5.
CC   -!- SUBUNIT: Tetramer of two components I and two components II (By
CC       similarity).
CC   -!- MISCELLANEOUS: Component I catalyzes the formation of anthranilate
CC       using ammonia rather than glutamine, whereas component II provides
CC       glutamine amidotransferase activity.
CC   -!- SIMILARITY: Belongs to the anthranilate synthase component I
CC       family.
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DR   EMBL; U09184; AAC31215.1; -; Genomic_DNA.
DR   HSSP; P00897; 1I7S.
DR   GO; GO:0004049; F:anthranilate synthase activity; IEA:EC.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005801; ADC_synthase.
DR   InterPro; IPR006805; Anth_synth_I_N.
DR   InterPro; IPR019999; Anthranilate_synth_I_C.
DR   InterPro; IPR015890; Chorismate-bd_C.
DR   InterPro; IPR005257; TrpE_synth.
DR   Gene3D; G3DSA:3.60.120.10; TRPE_1_chor_bd; 1.
DR   PANTHER; PTHR11236; TRPE_1_chor_bd; 1.
DR   Pfam; PF04715; Anth_synt_I_N; 1.
DR   Pfam; PF00425; Chorismate_bind; 1.
DR   PRINTS; PR00095; ANTSNTHASEI.
DR   ProDom; PD000779; Anth_synth_chor; 1.
DR   TIGRFAMs; TIGR00565; trpE_proteo; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Lyase;
KW   Tryptophan biosynthesis.
FT   CHAIN         1    530       Anthranilate synthase component 1.
FT                                /FTId=PRO_0000154087.
SQ   SEQUENCE   530 AA;  60189 MW;  2AE8702A6DBE7AB5 CRC64;
     MCEHLKSMDV LKVETFYQPN PTAIFHHICR NRSNTLLLES AEINNKKNLE SMMIVDSALR
     ISALNMVVTL EALTKNGESL LPVFKSLLPK EVRILSNDNF LKIKFPSIVK DIDEDKKLHV
     LSIFDSIRFL INSVKNNKGS KSMFFGGLFA YDLVSSFENL PKLKTSQSCP DFCFYLSEIL
     LVLNHKRRTC YIQASLFSSS NLERNKLQHR LLEVKNKLSQ NFYPLESTSL KKMILKCNRT
     DREYEKIIKE MKKSIMIGEI FQVVPSRKFY LPCTNSLAAY DVLKKNNPSP YMFFMQDSNF
     TLFGASPESS LKYDTLSRKI EIYPIAGTRP RARKIDGSID LDLDSRIELE MRTNHKELSE
     HLMLVDLARN DLAKICDPGT RYVADLTQVD KYSHVMHLVS RVVGKLRLDL DVFHAYQACM
     NMGTLSGAPK IRAMELISNA EKEKRGSYGG SIGYFTASGT LDMCIIIRSA YVENNIATIQ
     VGAGIVLDSI PQLEVDESKN KAKAVLQAIS ESHSCHIELN IENERHTFAG
//