Reviewed, UniProtKB/Swiss-Prot Q44598 (TRPE_BUCSC)

Names and origin

Protein names

Recommended name:
    Anthranilate synthase component 1
    EC=4.1.3.27
Alternative name(s):
    Anthranilate synthase component I

Gene names

Name:

trpE

Organism

Buchnera aphidicola subsp. Schlechtendalia chinensis

Taxonomic identifier

118110 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	530 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 530	530	Anthranilate synthase component 1		PRO_0000154087

Sequences

	Sequence		Length	Mass (Da)
	Q44598-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 2AE8702A6DBE7AB5	FASTA	530	60,189
	10 20 30 40 50 60 MCEHLKSMDV LKVETFYQPN PTAIFHHICR NRSNTLLLES AEINNKKNLE SMMIVDSALR 70 80 90 100 110 120 ISALNMVVTL EALTKNGESL LPVFKSLLPK EVRILSNDNF LKIKFPSIVK DIDEDKKLHV 130 140 150 160 170 180 LSIFDSIRFL INSVKNNKGS KSMFFGGLFA YDLVSSFENL PKLKTSQSCP DFCFYLSEIL 190 200 210 220 230 240 LVLNHKRRTC YIQASLFSSS NLERNKLQHR LLEVKNKLSQ NFYPLESTSL KKMILKCNRT 250 260 270 280 290 300 DREYEKIIKE MKKSIMIGEI FQVVPSRKFY LPCTNSLAAY DVLKKNNPSP YMFFMQDSNF 310 320 330 340 350 360 TLFGASPESS LKYDTLSRKI EIYPIAGTRP RARKIDGSID LDLDSRIELE MRTNHKELSE 370 380 390 400 410 420 HLMLVDLARN DLAKICDPGT RYVADLTQVD KYSHVMHLVS RVVGKLRLDL DVFHAYQACM 430 440 450 460 470 480 NMGTLSGAPK IRAMELISNA EKEKRGSYGG SIGYFTASGT LDMCIIIRSA YVENNIATIQ 490 500 510 520 530 VGAGIVLDSI PQLEVDESKN KAKAVLQAIS ESHSCHIELN IENERHTFAG

References

[1]	"Genetics of the tryptophan biosynthetic pathway of the prokaryotic endosymbiont (Buchnera) of the aphid Schlechtendalia chinensis." Lai C.-Y., Baumann P., Moran N.A. Insect Mol. Biol. 4:47-59(1995) [PubMed: 7742976] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	U09184 Genomic DNA. Translation: AAC31215.1.
3D structure databases
HSSP	HSSP built from PDB template 1I7S based on UniProtKB P00897.
ModBase	Search...
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR006805. Anth_synth_I_N. IPR019999. Anthranilate_synth_I_C. IPR015890. Chorismate-bd_C. IPR005257. TrpE_synth. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
PANTHER	PTHR11236. TRPE_1_chor_bd. 1 hit.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
ProDom	PD000779. Anth_synth_chor. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00565. trpE_proteo. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE_BUCSC

Accession

Primary (citable) accession number: Q44598

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)